Theophylline

46 interactions 1 explained in plain English
Also sold as: Accurbron® Aerolate® Aquaphyllin® Asbron® Bronkodyl® Duraphyl® Elixicon® Elixomin® Elixophyllin Elixophyllin® Labid® Lanophyllin® Quibron-T® Slo-Bid® Slo-Phyllin® Somophyllin® Sustaire® Synophylate® T-Phyll® Theo-24 Theo-24® Theo-Dur® Theobid® Theochron® Theoclear® Theolair® Theolixir® Theophyl® Theovent® Uni-dur® Uniphyl®
About Theophylline

Theophylline is a bronchodilator medication used to prevent and treat wheezing, shortness of breath, and chest tightness caused by lung diseases like asthma and chronic bronchitis. Read the full Theophylline drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Medroxyprogesterone Adalimumab Injection Capmatinib Levofloxacin Injection Estradiol Transdermal Patch Peginterferon Alfa-2A Injection
18 Major 18 Moderate 10 Minor
All (46) Major (18) Moderate (18) Minor (10)

Major

Theophylline Abametapir Explained Increased exposure of CYP1A2 substrates Details Theophylline Adalimumab Injection Abrilada Altered theophylline exposure Details Theophylline Capmatinib Tabrecta Increased CYP1A2 substrate exposure and an increased risk of adverse reactions Details Theophylline Deferasirox Exjade Increased theophylline concentrations Details Theophylline Enasidenib Idhifa Increased CYP1A2 substrate exposure and an increased risk of CYP1A2 substrate-related adverse effects Details Theophylline Estradiol Delestrogen Increased theophylline exposure and theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Estradiol Topical Divigel Increased theophylline exposure and theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Estradiol Transdermal Patch Alora® Increased theophylline exposure and theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Febuxostat Uloric Increased exposure to 1-methylxanthine, one of the major metabolites of theophylline Details Theophylline Hydroxychloroquine Plaquenil An increased risk of seizures Details Theophylline Levofloxacin Levaquin Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Levofloxacin Injection Levaquin Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Levonorgestrel After banger Increased theophylline exposure and theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Levonorgestrel Intrauterine System Kyleena Increased theophylline exposure and theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Medroxyprogesterone Amen® Increased theophylline exposure and theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Medroxyprogesterone Injection Depo-Provera Increased theophylline exposure and theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Mexiletine Mexitil® Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Peginterferon Alfa-2A Injection Pegasys Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details

Moderate

Theophylline Allopurinol Aloprim Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Allopurinol Injection Aloprim Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Azithromycin AzaSite Increase serum theophylline concentrations Details Theophylline Anagrelide Agrylin Increased theophylline serum concentrations and possible theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Diazepam Nasal Spray Valtoco Decreased benzodiazepine effectiveness Details Theophylline Diazepam Rectal Diastat Decreased benzodiazepine effectiveness Details Theophylline Disulfiram Antabuse Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Golimumab Injection Simponi Increased theophylline exposure Details Theophylline Interferon Alfa-2B Injection Intron A® Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Lithium Carbonate Lithobid Decreased lithium effectiveness Details Theophylline Methimazole Felanorm Altered theophylline metabolism Details Theophylline Methotrexate Jylamvo Increased theophylline exposure Details Theophylline Methotrexate Injection Abitrexate® Increased theophylline exposure Details Theophylline Midazolam Nasal Spray Nayzilam Decreased benzodiazepine effectiveness Details Theophylline Midazolam Injection Nayzilam Decreased benzodiazepine effectiveness Details Theophylline Nilutamide Nilandron An increased risk of theophylline toxicity (nausea, vomiting, palpitations, or seizures) Details Theophylline Obeticholic Acid Ocaliva Increased exposure to CYP1A2 substrate Details Theophylline Olodaterol Oral Inhalation Striverdi An increased risk of hypokalemia Details

Minor

Theophylline Albendazole Albendamax An increased risk of theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Capsaicin Arthricare for Women Moisturizing Increased theophylline absorption, and increased risk of theophylline toxicity Details Theophylline Capsaicin Topical Aspercreme Warming® Increased theophylline absorption, and increased risk of theophylline toxicity Details Theophylline Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased theophylline absorption, and increased risk of theophylline toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.