Theophylline

46 interactions 1 explained in plain English
Also sold as: Accurbron® Aerolate® Aquaphyllin® Asbron® Bronkodyl® Duraphyl® Elixicon® Elixomin® Elixophyllin Elixophyllin® Labid® Lanophyllin® Quibron-T® Slo-Bid® Slo-Phyllin® Somophyllin® Sustaire® Synophylate® T-Phyll® Theo-24 Theo-24® Theo-Dur® Theobid® Theochron® Theoclear® Theolair® Theolixir® Theophyl® Theovent® Uni-dur® Uniphyl®
About Theophylline

Theophylline is a bronchodilator medication used to prevent and treat wheezing, shortness of breath, and chest tightness caused by lung diseases like asthma and chronic bronchitis. Read the full Theophylline drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Medroxyprogesterone Adalimumab Injection Capmatinib Levofloxacin Injection Estradiol Transdermal Patch Peginterferon Alfa-2A Injection
18 Major 18 Moderate 10 Minor
All (46) Major (18) Moderate (18) Minor (10)

Moderate

Theophylline Allopurinol Aloprim Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Allopurinol Injection Aloprim Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Azithromycin AzaSite Increase serum theophylline concentrations Details Theophylline Anagrelide Agrylin Increased theophylline serum concentrations and possible theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Diazepam Nasal Spray Valtoco Decreased benzodiazepine effectiveness Details Theophylline Diazepam Rectal Diastat Decreased benzodiazepine effectiveness Details Theophylline Disulfiram Antabuse Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Golimumab Injection Simponi Increased theophylline exposure Details Theophylline Interferon Alfa-2B Injection Intron A® Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Theophylline Lithium Carbonate Lithobid Decreased lithium effectiveness Details Theophylline Methimazole Felanorm Altered theophylline metabolism Details Theophylline Methotrexate Jylamvo Increased theophylline exposure Details Theophylline Methotrexate Injection Abitrexate® Increased theophylline exposure Details Theophylline Midazolam Nasal Spray Nayzilam Decreased benzodiazepine effectiveness Details Theophylline Midazolam Injection Nayzilam Decreased benzodiazepine effectiveness Details Theophylline Nilutamide Nilandron An increased risk of theophylline toxicity (nausea, vomiting, palpitations, or seizures) Details Theophylline Obeticholic Acid Ocaliva Increased exposure to CYP1A2 substrate Details Theophylline Olodaterol Oral Inhalation Striverdi An increased risk of hypokalemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.