Thiopental

32 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Thiopental Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Thiopental Amitriptyline Elavil Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Thiopental Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Thiopental Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Thiopental Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Thiopental Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Thiopental Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Thiopental Diazepam Nasal Spray Valtoco An increased risk of CNS and respiratory depression Details Thiopental Diazepam Rectal Diastat An increased risk of CNS and respiratory depression Details Thiopental Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Thiopental Doxycycline Injection Acticlate Reduced doxycycline exposure and reduced efficacy of doxycycline Details Thiopental Esketamine Nasal Spray Spravato Increased risk of sedation Details Thiopental Esomeprazole Nexium Increased volume of distribution and prolonged half life of thiopental Details Thiopental Esomeprazole Injection Nexium Increased volume of distribution and prolonged half life of thiopental Details Thiopental Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Thiopental Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Thiopental Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Thiopental Lacosamide Injection Motpoly An increased risk of CNS depression Details Thiopental Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Thiopental Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Thiopental Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Thiopental Metoclopramide Injection Gimoti Increased risk of CNS depression Details Thiopental Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Thiopental Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Thiopental Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Thiopental Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Thiopental Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

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