Drug Interaction Report

Tolmetin and Meloxicam Injection: Interaction Details

Name: Tolmetin and Meloxicam Injection Interaction
Creator: Dr. Brian Staiger, PharmD, BCPS

A pharmacist-reviewed analysis of the Tolmetin and Meloxicam Injection interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Meloxicam Injection

Alloxate Anjeso Anjeso® Loxicom Meloxidyl Meloxivet Metacam Mobic

Tolmetin

Tolectin 600 Tolectin DS Tolectin® Tolectin® DS

Medically reviewed by

Dr. Brian Staiger, PharmD, BCPS

Updated Aug 8, 2026

Editorial policy · Data sources

Interaction severity

Major

Potentially serious — often needs a change or close monitoring.

Minor

Moderate

Major

Contraindicated

How we grade severity & evidence

Severity levels

Contraindicated: These should generally not be used together.
Major: Potentially serious — often needs a change or close monitoring.
Moderate: Can be significant — usually manageable with monitoring.
Minor: Usually limited clinical impact.

Evidence grades

Established: Well documented — supported by controlled studies or strong clinical data.
Probable: Good supporting evidence, though not definitively proven.
Suspected: Some evidence suggests this interaction, but it is not well established.
Possible: Limited or conflicting evidence; the interaction may occur.
Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 91 documented Tolmetin interactions, 59 are rated major — including this one.

Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.

Onset

unspecified

Evidence

theoretical

Severity

Major

What happens

An increased risk of gastrointestinal toxicity and an increased risk of bleeding

Interaction Deep Dive

Avoid coadministration of meloxicam (NSAID) with other NSAIDs and salicylate¹²³. Concomitant use of two NSAIDs or an NSAID and a salicylate as it may increase the risk of gastrointestinal toxicity including serious bleeding, with little or no increase in efficacy ¹²³⁴.

Why it happens (mechanism)

Unknown; additive effect on hemostasis

Common questions

Can I take Tolmetin and Meloxicam Injection together?

An increased risk of gastrointestinal toxicity and an increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.

How serious is the Tolmetin and Meloxicam Injection interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

Does my dose of Tolmetin or Meloxicam Injection need adjusting while I take them together?
What symptoms should prompt me to call you or my prescriber right away?
Does the timing of my doses matter for this combination?
Is there a safer alternative to one of these medications for me?

References (4)

Product Information: CALDOLOR(R) intravenous injection, ibuprofen intravenous injection. Cumberland Pharmaceuticals Inc. (per FDA), Nashville, TN, 2016. DailyMed
Product Information: NALFON oral capsules, fenoprofen calcium oral capsules. Xspire Pharma (per FDA), Ridgeland, MS, 2016. DailyMed
Product Information: MOBIC(R) oral tablets, oral suspension, meloxicam oral tablets, oral suspension. Boehringer Ingelheim Pharmaceuticals, Inc. (per FDA), Ridgefield, CT, 2016.
Product Information: SYMBRAVO(R) oral tablet, meloxicam rizatriptan oral tablet. Axsome Therapeutics Inc (per FDA), New York, NY, 2025. DailyMed

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Meloxicam Injection

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Tolmetin

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HelloPharmacist doesn't license one of the big commercial interaction databases, so what you'll find here is not a complete list of every known drug interaction. Instead, each entry is researched, analyzed, and written up individually — documented from the published literature, reviewed by a pharmacist, and cited so you can check every source yourself.

If a combination isn't listed here, it means we haven't documented it yet — never that it's safe. For screening a full medication list, we recommend pairing this site with a comprehensive tool like the Drugs.com Interaction Checker and, most importantly, a review by your own pharmacist. For a deep, plain-English, fully sourced explanation of a specific documented interaction — that's exactly what we built this for.

This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.