Tolmetin

91 interactions 5 explained in plain English
Also sold as: Tolectin 600 Tolectin DS Tolectin® Tolectin® DS
About Tolmetin

Tolmetin is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Tolmetin is also used to relieve pain, tenderness, swelling, and stiffness cau… Read the full Tolmetin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Nasal Spray Ketorolac Injection Ketorolac Ophthalmic Apixaban Pemetrexed Injection
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Major

Tolmetin Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Tolmetin Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Tolmetin Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Tolmetin Iloprost Aurlumyn An increased risk of bleeding Details Tolmetin Ketoprofen Actron® Increased risk of bleeding Details Tolmetin Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Tolmetin Meclofenamate Meclodium® Increased risk of bleeding Details Tolmetin Mefenamic Acid Ponstel® Increased risk of bleeding Details Tolmetin Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Tolmetin Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Tolmetin Melphalan Alkeran An increased risk of bleeding Details Tolmetin Melphalan Injection Alkeran An increased risk of bleeding Details Tolmetin Mesalamine Apriso Increased risk of bleeding Details Tolmetin Mesalamine Rectal Canasa Increased risk of bleeding Details Tolmetin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tolmetin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tolmetin Nabumetone Relafen Increased risk of bleeding Details Tolmetin Naproxen Aleve Increased risk of bleeding Details Tolmetin Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.