Trandolapril

62 interactions 1 explained in plain English
Also sold as: Mavik®
About Trandolapril

Trandolapril is used alone or in combination with other medications to treat high blood pressure. It is also used to improve survival in patients with heart failure after a heart attack. Trandolapril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemi… Read the full Trandolapril drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Trandolapril Aspirin Acuprin® Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Trandolapril Aspirin Rectal Aspirin Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Trandolapril Azathioprine Azasan Myelosuppression Details Trandolapril Azilsartan Edarbi Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Trandolapril Cyclosporine Injection Atopica Acute renal dysfunction and an increased risk of hyperkalemia Details Trandolapril Cyclosporine Ophthalmic Cequa Acute renal dysfunction and an increased risk of hyperkalemia Details Trandolapril Digoxin Cardoxin® An increased digoxin exposure Details Trandolapril Eprosartan Teveten® Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Trandolapril Everolimus Afinitor Increased risk of angioedema Details Trandolapril Furosemide Injection Disal An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Trandolapril Irbesartan Avapro Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Trandolapril Lithium Carbonate Lithobid Increased risk of lithium toxicity Details Trandolapril Losartan Arbli Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Trandolapril Melphalan Alkeran An increased risk of severe hypotension Details Trandolapril Melphalan Injection Alkeran An increased risk of severe hypotension Details Trandolapril Mercaptopurine Purinethol® Myelosuppression Details

Moderate

Trandolapril Acarbose Prandase® Explained An increased risk of hypoglycemia Details Trandolapril Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Trandolapril Alogliptin Nesina An increased risk of hypoglycemia Details Trandolapril Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Canagliflozin Invokana An increased risk of hypoglycemia Details Trandolapril Capsaicin Arthricare for Women Moisturizing Increased risk of cough Details Trandolapril Capsaicin Topical Aspercreme Warming® Increased risk of cough Details Trandolapril Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased risk of cough Details Trandolapril Dapagliflozin Farxiga An increased risk of hypoglycemia Details Trandolapril Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Diclofenac Transdermal Patch Flector Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Dulaglutide Injection Trulicity An increased risk of hypoglycemia Details Trandolapril Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hypoglycemia Details Trandolapril Ertugliflozin Steglatro An increased risk of hypoglycemia Details Trandolapril Etodolac Lodine Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Exenatide Injection Bydureon An increased risk of hypoglycemia Details Trandolapril Fenoprofen Fenopron Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Flurbiprofen Ansaid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Glimepiride Amaryl An increased risk of hypoglycemia Details Trandolapril Glipizide Glucotrol An increased risk of hypoglycemia Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.