Trandolapril

62 interactions 1 explained in plain English

Also sold as: Mavik®

About Trandolapril

Trandolapril is used alone or in combination with other medications to treat high blood pressure. It is also used to improve survival in patients with heart failure after a heart attack. Trandolapril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemi… Read the full Trandolapril drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Aliskiren Aspirin Mercaptopurine Everolimus Irbesartan Cyclosporine Injection

1 Contraindicated 16 Major 45 Moderate

All (62) Contraindicated (1) Major (16) Moderate (45)

Moderate

Trandolapril Acarbose Prandase® Explained An increased risk of hypoglycemia Details Trandolapril Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Trandolapril Alogliptin Nesina An increased risk of hypoglycemia Details Trandolapril Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Canagliflozin Invokana An increased risk of hypoglycemia Details Trandolapril Capsaicin Arthricare for Women Moisturizing Increased risk of cough Details Trandolapril Capsaicin Topical Aspercreme Warming® Increased risk of cough Details Trandolapril Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased risk of cough Details Trandolapril Dapagliflozin Farxiga An increased risk of hypoglycemia Details Trandolapril Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Diclofenac Transdermal Patch Flector Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Dulaglutide Injection Trulicity An increased risk of hypoglycemia Details Trandolapril Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hypoglycemia Details Trandolapril Ertugliflozin Steglatro An increased risk of hypoglycemia Details Trandolapril Etodolac Lodine Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Exenatide Injection Bydureon An increased risk of hypoglycemia Details Trandolapril Fenoprofen Fenopron Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Flurbiprofen Ansaid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Glimepiride Amaryl An increased risk of hypoglycemia Details Trandolapril Glipizide Glucotrol An increased risk of hypoglycemia Details Trandolapril Ibuprofen Addaprin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Trandolapril Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Trandolapril Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Trandolapril Ketoprofen Actron® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Ketorolac Acular Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Ketorolac Injection Acular Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Ketorolac Nasal Spray Sprix Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Ketorolac Ophthalmic Acular Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Lanthanum Fosrenol® Reduced bioavailability of ACE inhibitors Details Trandolapril Linagliptin Tradjenta An increased risk of hypoglycemia Details Trandolapril Liraglutide Injection Saxenda An increased risk of hypoglycemia Details Trandolapril Lixisenatide Injection Adlyxin® An increased risk of hypoglycemia Details Trandolapril Meclofenamate Meclodium® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Mefenamic Acid Ponstel® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Meloxicam Alloxate Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Trandolapril Meloxicam Injection Alloxate Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.