Ulipristal

31 interactions 2 explained in plain English
Also sold as: Ella Ella®
About Ulipristal

Ulipristal is used to prevent pregnancy after unprotected sexual intercourse (sex without any method of birth control or with a birth control method that failed or was not used properly [e.g., a condom that slipped or broke or birth control pills that were not taken as scheduled]). Ulipristal should not be used to prev… Read the full Ulipristal drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isotretinoin Meropenem Injection Nifedipine Estradiol Transdermal Patch Mitapivat Enasidenib
27 Major 4 Moderate
All (31) Major (27) Moderate (4)

Major

Ulipristal Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Ulipristal Bexarotene Targretin Decreased contraceptive effectiveness Details Ulipristal Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Ulipristal Dexamethasone Injection Decadron Reduced ulipristal exposure Details Ulipristal Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced ulipristal exposure Details Ulipristal Enasidenib Idhifa Reduced ulipristal exposure Details Ulipristal Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Ulipristal Estradiol Delestrogen Reduced efficacy of ulipristal or progestin-based hormonal contraceptives Details Ulipristal Estradiol Topical Divigel Reduced efficacy of ulipristal or progestin-based hormonal contraceptives Details Ulipristal Estradiol Transdermal Patch Alora® Reduced efficacy of ulipristal or progestin-based hormonal contraceptives Details Ulipristal Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Ulipristal Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Ulipristal Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Ulipristal Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Ulipristal Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Ulipristal Levonorgestrel After banger Reduced efficacy of ulipristal or progestin-based hormonal contraceptives Details Ulipristal Levonorgestrel Intrauterine System Kyleena Reduced efficacy of ulipristal or progestin-based hormonal contraceptives Details Ulipristal Loperamide Diamode Increased loperamide exposure Details Ulipristal Medroxyprogesterone Amen® Reduced efficacy of ulipristal or progestin-based hormonal contraceptives Details Ulipristal Medroxyprogesterone Injection Depo-Provera Reduced efficacy of ulipristal or progestin-based hormonal contraceptives Details Ulipristal Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Ulipristal Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Ulipristal Methylergonovine Methergine Increased methylergonovine exposure Details Ulipristal Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Ulipristal Nafcillin Injection Unipen® Injection Reduced ulipristal exposure Details Ulipristal Nevirapine Viramune Reduced ulipristal exposure Details Ulipristal Nifedipine Adalat® Increased NIFEdipine exposure Details

Moderate

Ulipristal Trospium / Xanomeline Cobenfy Explained Increased oral sensitive CYP3A4 substrate exposure and an increased risk on severity and frequency of sensitive CYP3A4 substrate-r... Details Ulipristal Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Ulipristal Dofetilide Tikosyn Increased dofetilide exposure Details Ulipristal Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.