Valdecoxib

94 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ketorolac Injection Ketorolac Ophthalmic Apixaban Pemetrexed Injection
4 Contraindicated 60 Major 28 Moderate 2 Minor
All (94) Contraindicated (4) Major (60) Moderate (28) Minor (2)

Major

Valdecoxib Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Valdecoxib Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Valdecoxib Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Valdecoxib Iloprost Aurlumyn An increased risk of bleeding Details Valdecoxib Ketoconazole Topical Extina® Foam Increased valdecoxib plasma exposure and increased risk of valdecoxib adverse effects Details Valdecoxib Ketoprofen Actron® Increased risk of bleeding Details Valdecoxib Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Valdecoxib Meclofenamate Meclodium® Increased risk of bleeding Details Valdecoxib Mefenamic Acid Ponstel® Increased risk of bleeding Details Valdecoxib Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Valdecoxib Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Valdecoxib Melphalan Alkeran An increased risk of bleeding Details Valdecoxib Melphalan Injection Alkeran An increased risk of bleeding Details Valdecoxib Mesalamine Apriso Increased risk of bleeding Details Valdecoxib Mesalamine Rectal Canasa Increased risk of bleeding Details Valdecoxib Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Valdecoxib Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Valdecoxib Nabumetone Relafen Increased risk of bleeding Details Valdecoxib Naproxen Aleve Increased risk of bleeding Details Valdecoxib Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.