Valdecoxib

94 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ketorolac Injection Ketorolac Ophthalmic Apixaban Pemetrexed Injection
4 Contraindicated 60 Major 28 Moderate 2 Minor
All (94) Contraindicated (4) Major (60) Moderate (28) Minor (2)

Moderate

Valdecoxib Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Valdecoxib Atenolol Tenormin Explained Reduced antihypertensive effect Details Valdecoxib Acebutolol Sectral® Reduced antihypertensive effect Details Valdecoxib Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Valdecoxib Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Valdecoxib Betaxolol Betoptic S Reduced antihypertensive effect Details Valdecoxib Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Valdecoxib Bisoprolol Zebeta® Reduced antihypertensive effect Details Valdecoxib Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Valdecoxib Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Valdecoxib Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Valdecoxib Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Valdecoxib Esmolol Brevibloc Reduced antihypertensive effect Details Valdecoxib Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Valdecoxib Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Valdecoxib Labetalol Normodyne® Reduced antihypertensive effect Details Valdecoxib Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Valdecoxib Levofloxacin Levaquin An increased risk of seizures Details Valdecoxib Levofloxacin Injection Levaquin An increased risk of seizures Details Valdecoxib Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Valdecoxib Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Valdecoxib Nadolol Corgard Reduced antihypertensive effect Details Valdecoxib Nebivolol Bystolic Reduced antihypertensive effect Details Valdecoxib Ofloxacin Floxin® An increased risk of seizures Details Valdecoxib Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Valdecoxib Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Valdecoxib Penbutolol Levatol® Reduced antihypertensive effect Details Valdecoxib Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.