Valdecoxib

94 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Valdecoxib Amitriptyline Elavil Explained An increased risk of bleeding Details Valdecoxib Sertraline Explained An increased risk of bleeding Details Valdecoxib Apixaban Eliquis Explained Increased risk of bleeding Details Valdecoxib Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Valdecoxib Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Valdecoxib Betrixaban Bevyxxa® An increased risk of bleeding Details Valdecoxib Anagrelide Agrylin An increased risk of bleeding Details Valdecoxib Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Valdecoxib Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Valdecoxib Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Valdecoxib Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Valdecoxib Clopidogrel Plavix An increased risk of bleeding Details Valdecoxib Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Valdecoxib Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Valdecoxib Dabigatran Pradaxa® Increased risk of bleeding Details Valdecoxib Dabigatran Etexilate Increased risk of bleeding Details Valdecoxib Dalteparin Injection Fragmin An increased risk of bleeding Details Valdecoxib Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Valdecoxib Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Valdecoxib Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Valdecoxib Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Valdecoxib Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Valdecoxib Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Valdecoxib Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Valdecoxib Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Valdecoxib Dipyridamole Permole® An increased risk of bleeding Details Valdecoxib Edoxaban Savaysa Increased risk of bleeding Details Valdecoxib Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Valdecoxib Enoxaparin Lovenox An increased risk of bleeding Details Valdecoxib Enoxaparin Injection Lovenox An increased risk of bleeding Details Valdecoxib Epoprostenol Flolan An increased risk of bleeding Details Valdecoxib Etodolac Lodine Increased risk of bleeding Details Valdecoxib Fenoprofen Fenopron Increased risk of bleeding Details Valdecoxib Flurbiprofen Ansaid Increased risk of bleeding Details Valdecoxib Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Valdecoxib Fondaparinux Arixtra Increased risk of bleeding Details Valdecoxib Fondaparinux Injection Arixtra Increased risk of bleeding Details Valdecoxib Furosemide Injection Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Valdecoxib Heparin Increased risk of bleeding Details Valdecoxib Heparin Injection Lipo-Hepin® Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.