Valdecoxib

Name: Valdecoxib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

94 interactions 5 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ketorolac Injection Ketorolac Ophthalmic Apixaban Pemetrexed Injection

4 Contraindicated 60 Major 28 Moderate 2 Minor

All (94) Contraindicated (4) Major (60) Moderate (28) Minor (2)

Moderate

Valdecoxib Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Valdecoxib Levofloxacin Levaquin An increased risk of seizures Details Valdecoxib Levofloxacin Injection Levaquin An increased risk of seizures Details Valdecoxib Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Valdecoxib Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Valdecoxib Nadolol Corgard Reduced antihypertensive effect Details Valdecoxib Nebivolol Bystolic Reduced antihypertensive effect Details Valdecoxib Ofloxacin Floxin® An increased risk of seizures Details Valdecoxib Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Valdecoxib Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Valdecoxib Penbutolol Levatol® Reduced antihypertensive effect Details Valdecoxib Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

Minor

Valdecoxib Diazepam Nasal Spray Valtoco Increased plasma exposure to diazepam and increased sedative side effects of diazepam Details Valdecoxib Diazepam Rectal Diastat Increased plasma exposure to diazepam and increased sedative side effects of diazepam Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.