Vepdegestrant

66 interactions 4 explained in plain English
Also sold as: Veppanu
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Vepdegestrant Amitriptyline Elavil Explained An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Sertraline Explained An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Buprenorphine Belbuca Explained An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Colchicine Colcrys Explained Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse reactions Details Vepdegestrant Amisulpride Injection Barhemsys An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Arsenic Trioxide Trisenox An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Aripiprazole Injection Abilify An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Azithromycin AzaSite An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Alfuzosin UroXatral An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Anagrelide Agrylin An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Bedaquiline Sirturo An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Chloroquine Aralen® An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Cyclosporine Injection Atopica Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse reactions Details Vepdegestrant Cyclosporine Ophthalmic Cequa Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse reactions Details Vepdegestrant Dapagliflozin Farxiga Increased dapagliflozin exposure and an increased risk of dapagliflozin-related adverse reactions Details Vepdegestrant Dasatinib Phyrago An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Degarelix Injection Firmagon An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Deutetrabenazine Austedo An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Digoxin Cardoxin® Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse reactions Details Vepdegestrant Disopyramide Norpace An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Dofetilide Tikosyn An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Dolasetron Anzemet An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Dolasetron Injection Anzemet An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Encorafenib Braftovi Reduced vepdegestrant exposure, reduced efficacy of vepdegestrant, an increased risk of QT interval prolongation and an increased... Details Vepdegestrant Entrectinib Rozlytrek An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Eribulin Injection Halaven An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Everolimus Afinitor Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse reactions Details Vepdegestrant Famotidine Calmicid An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Famotidine Injection Calmicid An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Felbamate Felbatol An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Flecainide Tambocor® An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Foscarnet Injection Foscavir An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Galantamine Razadyne An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Gemifloxacin Factive An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Glasdegib Daurismo An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Vepdegestrant Goserelin Implant Zoladex An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details

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