Drug & supplement interaction

1,4-butanediol + Aluminum Acetate

Aluminum Acetate brand name: Burow's Solution.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between 1,4-butanediol and Aluminum Acetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

1,4-butanediol and Aluminum Acetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Aluminum Acetate and 1,4-butanediol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

1,4-butanediol safety at a glance

1,4-butanediol overall Avoid This is a toxic chemical that turns into GHB in the body and can be life-threatening.
Pregnancy Unsafe When used orally. Read the full pregnancy detail
Breastfeeding Unsafe When used orally. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Aluminum Acetate and 1,4-butanediol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Aluminum Acetate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Aluminum Acetate is filed under a single classification — topical drugs. 1,4-butanediol has documented interactions with 10 drug classes — the most serious being alcohol (ethanol) (major), cns depressants (major) and narcotic drugs (major) — and none of Aluminum Acetate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

1,4-butanediol Does Interact With Other Medications

1,4-butanediol has 250 major, 21 moderate known drug interactions in our database — Aluminum Acetate isn’t one of them. If you take anything else, check it against the full list below.

Major 250 Moderate 21 No known interaction 2,559 (incl. Aluminum Acetate)
Taking anything else?

Check Another of Your Medications Against 1,4-butanediol

Covers the 2,830 medications we’ve checked against 1,4-butanediol. Pick one to open its full report.

What to actually watch for

What 1,4-butanediol Itself Has Been Linked To

This is not an interaction — nothing below involves Aluminum Acetate. It is the side-effect record for 1,4-butanediol on its own, from the licensed Natural Medicines monograph. If something new turns up after you add 1,4-butanediol, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms / Seizures Worth acting on Additional detail

    “Orally, 1,4-butanediol is metabolized to gamma-hydroxybutyrate (GHB), and its psychoactive effects are primarily due to GHB. 1,4-Butanediol also causes similar CNS toxic effects to GHB, including amnesia, combativeness, confusion, agitation, coma, seizures, and death. After 1,4-butanediol overdoses, sedation gradually increases, consistent with gradual conversion to GHB.”

    1,4-butanediol · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 102837. Stefani M, Roberts DM. 1,4-Butanediol overdose mimicking toxic alcohol exposure. Clin Toxicol (Phila) 2020;58(3):204-7. doi: 10.1080/15563650.2019.1617419. PubMed
    2. 1318. Smith SW, Zvosec DL. Death and central nervous system depression after ingestion of 1.4-butanediol, a gamma-hydroxybutyrate-related dietary supplement. Ann Emerg Med 2000;36:S85.
    3. 3678. Anon. FDA alert on misuse of consumer products containing GHB, GBL and BD. Food and Drug Administration, Rockville, MD. June 15, 1999.
    4. 3679. Anon. Important message for health professionals: Report serious adverse events associated with dietary supplements containing GBL, GHB or BD. Food and Drug Administration, Rockville, MD. August 25, 1999. Available at: http://vm.cfsan.fda.gov/~dms/mwg
    5. 10640. Zvosec DL, Smith SW, McCutcheon JR, et al. Adverse events, including death, associated with the use of 1,4-butanediol. N Engl J Med. 2001;344:87-94.. PubMed
    6. 37465. Thai, D., Dyer, J. E., Jacob, P., and Haller, C. A. Clinical pharmacology of 1,4-butanediol and gamma-hydroxybutyrate after oral 1,4-butanediol administration to healthy volunteers. Clin.Pharmacol Ther. 2007;81(2):178-184. PubMed
  • Memory problems / Hallucinations / Confusion Worth acting on Additional detail

    “1,4-butanediol is generally considered unsafe for any use. Any benefits do not outweigh the risks of toxicity.

    Most Common Adverse Effects:

    Orally: Agitation, amnesia, anxiety, bradycardia, chest tightness, confusion, hallucinations, nausea, tremor, vomiting.

    Serious Adverse Effects (Rare):

    Orally: Cardiac arrest, coma, death, respiratory depression.”

    1,4-butanediol · Natural Medicines adverse-effect record, reported in anxiety.

  • A slow heartbeat / Chest pain Worth acting on Additional detail

    “Orally, 1,4-butanediol and its metabolite, gamma-hydroxybutyrate (GHB), can cause chest tightness, bradycardia, and cardiac arrest.”

    1,4-butanediol · Natural Medicines adverse-effect record, reported in cardiac arrest.

    6 sources cited
    1. 1318. Smith SW, Zvosec DL. Death and central nervous system depression after ingestion of 1.4-butanediol, a gamma-hydroxybutyrate-related dietary supplement. Ann Emerg Med 2000;36:S85.
    2. 3678. Anon. FDA alert on misuse of consumer products containing GHB, GBL and BD. Food and Drug Administration, Rockville, MD. June 15, 1999.
    3. 3679. Anon. Important message for health professionals: Report serious adverse events associated with dietary supplements containing GBL, GHB or BD. Food and Drug Administration, Rockville, MD. August 25, 1999. Available at: http://vm.cfsan.fda.gov/~dms/mwg
    4. 6016. Timby N, Eriksson A. Gamma-Hydroxybutyrate-Associated Deaths. Am J Med 2000;108:518. PubMed
    5. 10640. Zvosec DL, Smith SW, McCutcheon JR, et al. Adverse events, including death, associated with the use of 1,4-butanediol. N Engl J Med. 2001;344:87-94.. PubMed
    6. 37465. Thai, D., Dyer, J. E., Jacob, P., and Haller, C. A. Clinical pharmacology of 1,4-butanediol and gamma-hydroxybutyrate after oral 1,4-butanediol administration to healthy volunteers. Clin.Pharmacol Ther. 2007;81(2):178-184. PubMed
  • Tremor or shakiness / Anxiety or restlessness Additional detail

    Recorded for 1,4-butanediol in the same Natural Medicines adverse-effect record shown under Memory problems / Hallucinations / Confusion above.

  • Drowsiness Additional detail

    Recorded for 1,4-butanediol in the same Natural Medicines adverse-effect record shown under Dependence or withdrawal symptoms / Seizures above.

Showing the 10 most notable of 14 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for 1,4-butanediol — expand a row for the licensed statement it rests on. We haven’t matched Aluminum Acetate to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Aluminum Acetate.

Special populations

1,4-butanediol in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Aluminum Acetate

This page covers 1,4-butanediol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aluminum Acetate page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Aluminum Acetate page

“Aluminum acetate (Burow's Solution) is the soak or compress people reach for with weepy rashes, athlete's foot, or swimmer's ear, and its three supplement interactions on file all come down to what else touches that same patch of skin. None is rated major, and this is a list most people can handle with a little attention rather than al…”

Reviewed by 2 · Jul 18, 2026

Open the Aluminum Acetate interaction page

How much people look this up

Where 1,4-butanediol and Aluminum Acetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 1,4-butanediol
Top half

#700 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aluminum Acetate
Steady interest

#1,605 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 1,4-butanediol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The 1,4-butanediol and Aluminum Acetate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 1,4-butanediol

What is 1,4-butanediol?

  • Marketed illegally as a 'recreational' or party substance
  • Falsely sold as a sleep aid
  • Falsely promoted for bodybuilding or muscle growth
  • Industrial solvent and chemical manufacturing

1,4-butanediol is a toxic industrial chemical, not a safe dietary supplement. Once swallowed, the body converts it into GHB, a powerful central nervous system depressant that can cause coma, dangerous breathing problems, addiction, and death. It should never be taken as a supplement or recreational substance.

Synthetic industrial chemical (not a plant) · Liquid solvent (sometimes sold illegally as a 'supplement,' cleaner, or party drug)

An interaction check asks whether these two react with each other — it does not ask whether 1,4-butanediol is a good idea for someone in your situation. Here is what our 1,4-butanediol record says about it on its own.

1,4-butanediol: dosing

There is no established or recommended dose of 1,4-butanediol, because it is not a legitimate supplement or medicine. It should not be taken in any amount.If you have encountered a product that contains or is suspected to contain 1,4-butanediol, do not use it. In the U.S., you can reach Poison Control at 1-800-222-1222.

From our 1,4-butanediol monograph — the full record covers uses, side effects and every documented interaction.

Read the full 1,4-butanediol monograph & all interactions
Medication

About Aluminum Acetate

What Is Aluminum Acetate Used For?

Brand name: Burow's Solution

Aluminum acetate is applied to the skin to temporarily ease the itch, irritation, and discomfort of a range of common skin conditions. Most products — including Tricalm Hydrogel, TriCalm, and Dermeleve cream — are used for poison ivy, poison oak, poison sumac, insect bites, athlete's foot, and rashes caused by soaps, detergents, cosmetics, or jewelry.

Dermeleve cream also lists minor burns among its uses. Dermeleve Anti Itch Scalp Serum is specifically formulated for scalp itch and rashes from soaps, detergents, or cosmetics applied to the scalp. The ZO Skin Health powder products target rashes from soaps, detergents, cosmetics, or jewelry.

Most-Reported Side Effects for Aluminum Acetate

From FAERS, the FDA’s public side-effect reporting system (40 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 19 reports
Hypersensitivity 16 reports
Nausea 16 reports
Therapeutic product effect decreased 16 reports
Contraindicated product administered 6 reports
See full Aluminum Acetate drug information
Keep checking

Other Drugs & 1,4-butanediol

Browse every other medication we’ve checked against 1,4-butanediol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

250Major
21Moderate
0Minor
2,558No known interaction
250 Major 21 Moderate 2,558 No interaction
Major

250 interactions

Showing 60 of 250 major interactions — see all 250 on the 1,4-butanediol page.

Moderate

21 interactions

No interaction 2,558 drugs checked — show the list

We also checked 1,4-butanediol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,558 medications checked with no known interaction — see the full 1,4-butanediol list.

See the full 1,4-butanediol interactions page
See every supplement checked against Aluminum Acetate, ranked by severity
Evidence & sources

1,4-butanediol References

The 20 references that drive our 1,4-butanediol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Smith SW, Zvosec DL. Death and central nervous system depression after ingestion of 1.4-butanediol, a gamma-hydroxybutyrate-related dietary supplement. Ann Emerg Med 2000;36:S85.
  2. Anon. Adverse events associated with ingestion of gamma-butyrolactone--Minnesota, New Mexico, and Texas, 1998-1999. MMWR Morb Mortal Wkly Rep 1999;48:137-40.
  3. Harrington RD, Woodward JA, Hooton TM, et al. Life-threatening interactions between HIV-1 protease inhibitors and the illicit drugs MDMA and gamma-hydroxybutyrate. Arch Intern Med 1999;159:2221-4.
  4. Anon. FDA alert on misuse of consumer products containing GHB, GBL and BD. Food and Drug Administration, Rockville, MD. June 15, 1999.
  5. Anon. Important message for health professionals: Report serious adverse events associated with dietary supplements containing GBL, GHB or BD. Food and Drug Administration, Rockville, MD. August 25, 1999. Available at: http://vm.cfsan.fda.gov/~dms/mwg
  6. Anon. Multistate outbreak of poisonings associated with illicit use of gamma hydroxy butyrate. JAMA 1991;265:447-8. DOI
  7. Carotenuto A, De Feo V, Fattorusso E, et al. The flavonoids of Allium ursinum. Phytochem 1996;41:531-6. PubMed
  8. Ferrara SD, Tedeschi L, Frison G, Rossi A. Fatality due to gamma-hydroxybutyric acid (GHB) and heroin intoxication. J Forensic Sci 1995;40:501-4. DOI
  9. Timby N, Eriksson A. Gamma-Hydroxybutyrate-Associated Deaths. Am J Med 2000;108:518. PubMed
  10. Schneir AB, Ly BT, Clark RF. A case of withdrawal from the GHB precursors gamma-butyrolactone and 1,4-butanediol. J Emerg Med 2001;21:31-3.. PubMed
  11. Zvosec DL, Smith SW, McCutcheon JR, et al. Adverse events, including death, associated with the use of 1,4-butanediol. N Engl J Med. 2001;344:87-94.. PubMed
  12. Mason P, Kerns II W. Gamma Hydroxybutyric Acid (GHB) Intoxication. Acad Emerg Med 2002;9:730-39.. DOI
  13. Poldrugo, F., Barker, S., Basa, M., Mallardi, F., and Snead, O. C. Ethanol potentiates the toxic effects of 1,4-butanediol. Alcohol Clin.Exp.Res 1985;9(6):493-497. PubMed
  14. Thai, D., Dyer, J. E., Jacob, P., and Haller, C. A. Clinical pharmacology of 1,4-butanediol and gamma-hydroxybutyrate after oral 1,4-butanediol administration to healthy volunteers. Clin.Pharmacol Ther. 2007;81(2):178-184. PubMed
  15. Boscolo-Berto R, Viel G, Montagnese S, Raduazzo DI, Ferrara SD, Dauvilliers Y. Narcolepsy and effectiveness of gamma-hydroxybutyrate (GHB): a systematic review and meta-analysis of randomized controlled trials. Sleep Med Rev. 2012 Oct;16(5):431-43. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 1,4-butanediol and Aluminum Acetate Together: Common Questions

Is it safe to take 1,4-butanediol with Aluminum Acetate?
We do not list a known interaction between 1,4-butanediol and Aluminum Acetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the 1,4-butanediol and Aluminum Acetate combination checked?
Interactions in our licensed database are recorded against drug classes. Aluminum Acetate is filed under 1 classification, and 1,4-butanediol has documented interactions with 10 drug classes — none of Aluminum Acetate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 1,4-butanediol interact with any other medications?
Yes. 1,4-butanediol has 271 documented drug interactions in our database — Aluminum Acetate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Aluminum Acetate interact with any supplements?
Yes. Aluminum Acetate has documented interactions with 3 supplements in our database — 1,4-butanediol is not one of them. The Aluminum Acetate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

1,4-butanediol monograph Uses, safety profile, and every drug interaction in one place Aluminum Acetate drug information The full plain-English guide to this medication Aluminum Acetate supplement interactions Every supplement checked against Aluminum Acetate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 20 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Aluminum Acetate and 1,4-butanediol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.