Drug & supplement interaction

Allspice + Methylene Blue

Methylene Blue brand names: Urolene Blue, Provayblue.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Allspice and Methylene Blue in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Allspice and Methylene Blue

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methylene Blue and Allspice in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Allspice safety at a glance

Allspice overall Use caution Food amounts are generally safe, but concentrated extracts and essential oil need caution and lack strong safety data.
Pregnancy Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of allspice when used in larger amoun... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of allspice when used in larger amoun... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methylene Blue and Allspice? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Methylene Blue

Interactions in our licensed database are recorded against drug classes, not just single drug names. Methylene Blue is filed under 3 classifications — serotonergic drugs, serotonergic drugs, oral drugs. Allspice has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Methylene Blue’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Allspice Does Interact With Other Medications

Allspice has 122 moderate known drug interactions in our database — Methylene Blue isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Methylene Blue)
Taking anything else?

Check Another of Your Medications Against Allspice

Covers the 2,830 medications we’ve checked against Allspice. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Allspice and Methylene Blue May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction Worth acting on Additional detail

    Allspice

    “Orally and topically, allspice can cause allergic dermatitis in sensitive people. A case report describes a 41-year-old female with a history of allergic reactions to certain foods and drinks, with symptoms including lip angioedema, generalized hives and urticaria, vomiting, difficulty breathing, sneezing, ocular pruritus, and lacrimation, which responded to oral diphenhydramine.”

    Allspice · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 12635. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
    2. 30654. Niinimaki, A. Delayed-type allergy to spices. Contact Dermatitis 1984;11(1):34-40. PubMed
    3. 109925. Regula P, Edelman D, Ferastraoaru D, Ramesh M, Hudes G. Severe allergic reaction to allspice, a hidden food allergen. Ann Allergy Asthma Immunol. 2022;129(2):241-2. PubMed

    Methylene Blue

    Listed in the ADVERSE REACTIONS section of the FDA label for Methylene Blue. Read the label on DailyMed ›

Reported for Allspice but not commonly for Methylene Blue: shortness of breath, an allergic reaction, a skin rash and hives.

Effects for Methylene Blue come from the ADVERSE REACTIONS section of its FDA label; effects for Allspice come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Allspice in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of allspice when used in larger amounts as medicine; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Methylene Blue

This page covers Allspice only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methylene Blue page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lithium (major), 5-htp (moderate), Acetyl-l-carnitine (moderate) and Ayahuasca (moderate).

By severity: 2 major · 25 moderate · 11 minor.

From our pharmacist’s overview on the Methylene Blue page

“The pairing I would worry about first with methylene blue (Urolene Blue, Provayblue) is anything that raises serotonin, and lithium heads that group with a major rating. Methylene blue inhibits monoamine oxidase A, the enzyme that breaks serotonin down, so combining it with serotonin-boosting supplements can tip someone into serotonin…”

Reviewed by 2 · Jul 18, 2026

Open the Methylene Blue interaction page

One more smart check

Taking Allspice as Part of a Dietary Supplement Product? Check It for Interactions

We hold 133 real supplement products containing Allspice, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Allspice. Even though Allspice itself has no known interaction with Methylene Blue, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Allspice and Methylene Blue Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Allspice
Top half

#486 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methylene Blue
Top 5%

#53 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Allspice reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Allspice and Methylene Blue records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Allspice

What is Allspice?

Allspice
  • Digestive upset and gas
  • Muscle and joint pain (topical)
  • Toothache and oral discomfort
  • Antimicrobial uses
  • Flavoring in food and drinks

Allspice is a popular cooking spice from a Caribbean evergreen tree that has long been used in folk medicine for digestion, pain, and infections. There is very little high-quality human research to support these medicinal uses, so it is best thought of as a flavorful food rather than a proven treatment. Amounts used in cooking are generally considered safe, but concentrated extracts and the essential oil should be used carefully.

Pimenta dioica · Myrtaceae · Dried unripe berries, leaves, and essential oil · Whole or ground spice, tea, extract, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Allspice is a good idea for someone in your situation. Here is what our Allspice record says about it on its own.

Allspice: dosing

There is no established standard medicinal dose for allspice. Most people only encounter it in the small amounts used to flavor food, which are considered safe.For supplements, teas, or extracts, there is not enough reliable research to recommend a specific amount. If you choose to use a product, follow the directions on the label and do not exceed them.The essential oil is highly concentrated and should only be used externally and well diluted, never taken by mouth without professional guidance.

From our Allspice monograph — the full record covers uses, side effects and every documented interaction.

Read the full Allspice monograph & all interactions
Keep checking

Other Drugs & Allspice

Browse every other medication we’ve checked against Allspice — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Allspice page.

No interaction 2,707 drugs checked — show the list

We also checked Allspice against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Allspice list.

See the full Allspice interactions page
See every supplement checked against Methylene Blue, ranked by severity
Evidence & sources

Allspice References

The 5 references that drive our Allspice monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
  3. Chen SJ, Wang MH, Chen IJ. Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. Gen Pharmacol 1996;27:629-33. PubMed
  4. Niinimaki, A. Delayed-type allergy to spices. Contact Dermatitis 1984;11(1):34-40. PubMed
  5. Regula P, Edelman D, Ferastraoaru D, Ramesh M, Hudes G. Severe allergic reaction to allspice, a hidden food allergen. Ann Allergy Asthma Immunol. 2022;129(2):241-2. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Allspice and Methylene Blue Together: Common Questions

Is it safe to take Allspice with Methylene Blue?
We do not list a known interaction between Allspice and Methylene Blue. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Allspice and Methylene Blue have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Allspice and Methylene Blue combination checked?
Interactions in our licensed database are recorded against drug classes. Methylene Blue is filed under 3 classifications, and Allspice has documented interactions with 1 drug class — none of Methylene Blue's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Allspice interact with any other medications?
Yes. Allspice has 122 documented drug interactions in our database — Methylene Blue is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Methylene Blue interact with any supplements?
Yes. Methylene Blue has documented interactions with 38 supplements in our database — Allspice is not one of them. The Methylene Blue interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Allspice monograph Uses, safety profile, and every drug interaction in one place Methylene Blue supplement interactions Every supplement checked against Methylene Blue, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methylene Blue and Allspice?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.