Alpha-alanine - Ofev (Nintedanib Esylate) Interaction
Herbal: Alpha-alanine
Also Known As: 2-aminopropionic Acid, Ala, Alanine Amino Acid, Alpha-Alanine, Alpha-aminopropionic Acid, D-alanine, D-alpha-alanine, DL-alanine, L-alanine, L-alpha-alanine, L-alpha-aminopropionic Acid
Drug: Nintedanib Esylate
Brand names:
Ofev
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
There were no interactions found between Nintedanib Esylate and Alpha-alanine. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Alpha-alanine Overview
Alanine, a non-essential amino acid, has two forms: L-alpha-alanine and D-alpha-alanine. L-alpha-alanine is vital in protein synthesis and gluconeogenesis, sourced from diet, amino acid conversion, and glucose metabolism. It stimulates glucagon secretion, raising blood glucose levels in type 1 diabetes without affecting C-peptide or insulin. Conversely, in non-diabetics, it balances glucose levels. Animal studies suggest L-alpha-alanine may improve glutathione levels, enhance electrolyte absorption, reduce ketosis after exertion, and impact glycogen storage disease type II. D-alpha-alanine is explored for neurological effects, acting as an NMDA receptor agonist.
Nintedanib Esylate Overview
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Nintedanib is used to treat idiopathic pulmonary fibrosis (IPF; scarring of the lungs with an unknown cause). It is also used to treat certain types of chronic fibrosing interstitial lung diseases (ILD; an ongoing disease in which there is increased scarring of the lungs). Nintedanib is also used to slow the rate of decline in lung function in people with systemic sclerosis-associated interstitial lung disease (SSc-ILD; also known as scleroderma-associated ILD: a disease in which there is scarring of the lungs that is often fatal). Nintedanib is in a class of medications called kinase inhibitors. It works by blocking the action of enzymes involved in causing fibrosis.
Alpha-alanine - More Interactions
Alpha-alanine interacts with 0 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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