Alpha-ketoglutarate (akg) + Pimozide
Pimozide brand name: Orap.
We found no known interaction between Alpha-ketoglutarate (akg) and Pimozide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Alpha-ketoglutarate (akg) and Pimozide
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Pimozide and Alpha-ketoglutarate (akg) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Alpha-ketoglutarate (akg) at all — not against Pimozide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Alpha-ketoglutarate (akg) safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Pimozide
This page covers Alpha-ketoglutarate (akg) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pimozide page lists 180 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).
By severity: 12 major · 127 moderate · 41 minor.
From our pharmacist’s overview on the Pimozide page
“Pimozide (Orap), prescribed mainly for severe tics in Tourette syndrome, is a medicine I ask patients to check every supplement against before adding it. Twelve of the 180 ingredients on file rate major, and most of the risk runs through one pathway: 121 of them affect CYP3A4, the enzyme that clears pimozide.”
Reviewed by 2 · Jul 18, 2026
Where Alpha-ketoglutarate (akg) and Pimozide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,222 of 1,452 supplements looked up here in the last 7 days
#2,286 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Alpha-ketoglutarate (akg) is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Alpha-ketoglutarate (akg) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Alpha-ketoglutarate (akg) and Pimozide records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Alpha-ketoglutarate (akg)
What is Alpha-ketoglutarate (akg)?
- Anti-aging and longevity support
- Athletic performance and recovery
- Muscle building
- Bone health
- General metabolic and energy support
Alpha-ketoglutarate (AKG) is a natural molecule in the body's energy-making (Krebs) cycle that is now sold as a supplement, mainly marketed for longevity, exercise, and muscle support. Most human evidence is limited or early, and many popular claims rest on lab or animal studies, so benefits are not well proven. Talk with your pharmacist or doctor before starting it, especially if you are pregnant, breastfeeding, or have a health condition.
Not applicable (a naturally occurring metabolic molecule, made synthetically for supplements) · Capsules, tablets, powders; often as calcium alpha-ketoglutarate (Ca-AKG), arginine alpha-ketoglutarate (AAKG), or ornithine alpha-ketoglutarate (OKG)
An interaction check asks whether these two react with each other — it does not ask whether Alpha-ketoglutarate (akg) is a good idea for someone in your situation. Here is what our Alpha-ketoglutarate (akg) record says about it on its own.
Alpha-ketoglutarate (akg): dosing
There is no official, established dose of AKG for any health condition. Doses used in studies have varied widely depending on the form (calcium AKG, arginine AKG, or ornithine AKG) and the purpose.The safest approach is to follow the directions on the product label and not exceed the recommended amount.
From our Alpha-ketoglutarate (akg) monograph — the full record covers uses, side effects and every documented interaction.
About Pimozide
What Is Pimozide Used For?
Brand name: Orap
Pimozide tablets are used to suppress motor tics (involuntary movements) and phonic tics (involuntary sounds or words) in people with Tourette's Disorder. It is reserved for patients whose daily life or development is severely affected by their tics — it is not intended as a first-line treatment, and it is not used for tics that are mild or mainly cosmetic concerns.
Pimozide is not meant for tics caused by other conditions or medications, and it should not be used for simple tics unrelated to Tourette's Disorder.
Most-Reported Side Effects for Pimozide
From FAERS, the FDA’s public side-effect reporting system (471 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Alpha-ketoglutarate (akg)
Browse every other medication we’ve checked against Alpha-ketoglutarate (akg) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Alpha-ketoglutarate (akg) against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Lisinopril ›
- Amoxicillin ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Citalopram ›
- Buspirone ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Alpha-ketoglutarate (akg) list.
Alpha-ketoglutarate (akg) References
The 2 sources that drive our Alpha-ketoglutarate (akg) monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Alpha-ketoglutarate (akg) is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Arginine — NIH Office of Dietary Supplements / MedlinePlus Source
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Alpha-ketoglutarate (akg) and Pimozide Together: Common Questions
Is it safe to take Alpha-ketoglutarate (akg) with Pimozide?
Does Pimozide interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.