Drug & supplement interaction

Amaranth + Fentanyl

Fentanyl brand names: Sublimaze, Duragesic, Fentora, Lazanda, Abstral, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Amaranth and Fentanyl in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Amaranth and Fentanyl

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fentanyl and Amaranth in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Amaranth at all — not against Fentanyl, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Amaranth safety at a glance

Amaranth overall Use caution Generally safe as a food, but medicinal supplement doses are not well studied.
Pregnancy Use caution Food amounts are likely fine, but avoid concentrated medicinal doses due to lack of safety data.
Breastfeeding Use caution Food amounts are likely fine, but supplement-level doses have not been studied.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fentanyl and Amaranth? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Fentanyl’s Own FDA Label Lists

This is not an interaction — none of it involves Amaranth. These are the most notable effects listed in the ADVERSE REACTIONS section of Fentanyl’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms Worth acting on mentioned in 5.6% of FDA reports for Fentanyl
  • Low magnesium Worth acting on
  • Serotonin syndrome Worth acting on
  • Hearing loss Worth acting on
  • A bowel blockage Worth acting on
  • Bone thinning Worth acting on
  • Pain or burning when passing urine Worth acting on
  • Muscle weakness Worth acting on
  • Memory problems Worth acting on
  • Dehydration Worth acting on

Showing the 10 most notable of 78 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Fentanyl. Read the label on DailyMed › Where a percentage is shown, it is the share of 114,883 voluntary FDA FAERS reports for Fentanyl that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Amaranth’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Amaranth side to compare — that is a limit of the record, not a statement that Amaranth has no side effects.

From our Q&A

Questions About Amaranth or Fentanyl

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Amaranth or Fentanyl, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Fentanyl

This page covers Amaranth only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fentanyl page lists 226 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 10 major · 176 moderate · 40 minor.

From our pharmacist’s overview on the Fentanyl page

“There is very little room for error with fentanyl (Duragesic, Sublimaze, Actiq, and other forms), a powerful opioid where a modest rise in blood level or an extra layer of sedation can become dangerous, so this interaction list deserves real respect. Most of the risk falls into two patterns.”

Reviewed by 2 · Jul 18, 2026

Open the Fentanyl interaction page

One more smart check

Taking Amaranth as Part of a Dietary Supplement Product? Check It for Interactions

We hold 404 real supplement products containing Amaranth, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Amaranth. Even though Amaranth itself has no known interaction with Fentanyl, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Amaranth and Fentanyl Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Amaranth
Top half

#417 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fentanyl
Top half

#1,131 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Amaranth reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Amaranth and Fentanyl records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Amaranth

What is Amaranth?

Amaranth
  • Nutrition and as a gluten-free grain
  • High cholesterol
  • Diarrhea and digestive upset
  • Mouth and throat irritation (gargle)
  • Wound and skin care (traditional)

Amaranth is a nutritious plant whose seeds are used as a gluten-free pseudocereal and whose leaves are eaten as a vegetable. It is generally considered safe as a food, but evidence for its medicinal benefits (such as lowering cholesterol) is limited and mostly preliminary. Talk to your pharmacist or doctor before using concentrated supplements.

Amaranthus spp. · Amaranthaceae · Leaves, seeds, seed oil, roots, and whole plant · Seeds and flour (pseudocereal), leafy vegetable, seed oil, capsules, powders, and teas

An interaction check asks whether these two react with each other — it does not ask whether Amaranth is a good idea for someone in your situation. Here is what our Amaranth record says about it on its own.

Amaranth: dosing

There is no established standardized medicinal dose for amaranth. As a food, it is simply prepared and eaten like other grains or leafy vegetables.If you choose a supplement, oil, or capsule, follow the directions on the product label, since the amount of active ingredients can vary widely between products.

From our Amaranth monograph — the full record covers uses, side effects and every documented interaction.

Read the full Amaranth monograph & all interactions
Medication

About Fentanyl

What Is Fentanyl Used For?

Brand names: Sublimaze, Duragesic, Fentora, Lazanda, Abstral, Subsys

Fentanyl transdermal system is prescribed for severe, persistent pain that cannot be controlled with other pain medicines, including shorter-acting opioids. It is only for people who are already opioid-tolerant — meaning they've been taking a significant daily opioid dose for at least a week.

It is not for short-term pain, post-surgical pain, mild pain, or use on an as-needed basis. Because of serious risks including addiction, overdose, and death, it is reserved for situations where other treatment options have failed or are not appropriate.

Most-Reported Side Effects for Fentanyl

From FAERS, the FDA’s public side-effect reporting system (114,883 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug abuse 12,447 reports
Overdose 8,162 reports
Toxicity to various agents 7,374 reports
Drug dependence 6,445 reports
Nausea 5,689 reports
See full Fentanyl drug information
Keep checking

Other Drugs & Amaranth

Browse every other medication we’ve checked against Amaranth — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Amaranth against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Amaranth list.

See the full Amaranth interactions page
See every supplement checked against Fentanyl, ranked by severity
Evidence & sources

Amaranth References

The 6 references that drive our Amaranth monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Maier SM, Turner ND, Lupton JR. Serum lipids in hypercholesterolemic men and women consuming oat bran and amaranth products. Cereal Chem 2000:77;297-302. DOI
  2. Martirosyan, D. M., Miroshnichenko, L. A., Kulakova, S. N., Pogojeva, A. V., and Zoloedov, V. I. Amaranth oil application for coronary heart disease and hypertension. Lipids Health Dis. 2007;6:1.
  3. Cherkas A, Zarkovic K, Cipak Gasparovic A, et al. Amaranth oil reduces accumulation of 4-hydroxynonenal-histidine adducts in gastric mucosa and improves heart rate variability in duodenal peptic ulcer patients undergoing Helicobacter pylori eradication. F
  4. Dus-Zuchowska M, Walkowiak J, Morawska A, et al. Amaranth oil increases total and LDL cholesterol levels without influencing early markers of atherosclerosis in an overweight and obese population: A randomized double-blind cross-over study in comparison w
  5. Orsango AZ, Loha E, Lindtjørn B, Engebretsen IMS. Efficacy of processed amaranth-containing bread compared to maize bread on hemoglobin, anemia and iron deficiency anemia prevalence among two-to-five year-old anemic children in Southern Ethiopia: A cluste
  6. Moszak M, Zawada A, Juchacz A, Grzymislawski M, Bogdanski P. Comparison of the effect of rapeseed oil or amaranth seed oil supplementation on weight loss, body composition, and changes in the metabolic profile of obese patients following 3-week body mass

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Amaranth and Fentanyl Together: Common Questions

Is it safe to take Amaranth with Fentanyl?
We do not list a known interaction between Amaranth and Fentanyl. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Fentanyl interact with any supplements?
Yes. Fentanyl has documented interactions with 226 supplements in our database — Amaranth is not one of them. The Fentanyl interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Amaranth monograph Uses, safety profile, and every drug interaction in one place Fentanyl drug information The full plain-English guide to this medication Fentanyl supplement interactions Every supplement checked against Fentanyl, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fentanyl and Amaranth?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.