American Chestnut - Eucrisa (Crisaborole) Interaction

Castanea dentata, commonly known as the American chestnut, is a large deciduous tree native to the eastern United States. Once dominant in the region, it faced devastation from the chestnut blight, a fungal disease originating from Asia. Efforts are now underway to breed blight-resistant varieties and reintroduce them to their native habitats. Medicinally, the tree is used orally for cough, pertussis, respiratory ailments, as an antirheumatic, sedative, tonic, and astringent agent. Topically, it is used for pharyngitis. Additionally, an extract of the tree is used in beverages. The leaf and bark contain tannins, which can alter the absorption of foods and nutrients by binding with digestive enzymes, alkaloid substances, minerals, and nitrogen-rich compounds. The leaf, containing 8% to 9% tannins, exerts an astringent effect on mucosal tissue, dehydrating it, reducing internal secretions, and forming external cells into a protective layer.