Drug & supplement interaction

American Ivy + Setmelanotide

Setmelanotide brand name: Imcivree.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between American Ivy and Setmelanotide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

American Ivy and Setmelanotide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Setmelanotide and American Ivy in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

American Ivy safety at a glance

American Ivy overall Use caution Little safety data exists, and the berries are toxic, so use it cautiously and avoid eating any part of the plant.

Pregnancy Avoid There is not enough safety information, so it is best to avoid use during pregnancy.

Breastfeeding Avoid Safety while breastfeeding is unknown, so avoiding it is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Setmelanotide and American Ivy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

Keep it in perspective

American Ivy Does Interact With Other Medications

American Ivy has 56 moderate known drug interactions in our database — Setmelanotide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 56 No known interaction 2,774 (incl. Setmelanotide)

Taking anything else?

Check Another of Your Medications Against American Ivy

Covers the 2,830 medications we’ve checked against American Ivy. Pick one to open its full report.

What to actually watch for

What Setmelanotide’s Own FDA Label Lists

This is not an interaction — none of it involves American Ivy. These are the most notable effects listed in the ADVERSE REACTIONS section of Setmelanotide’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

Thoughts of self-harm Worth acting on
Low sodium Worth acting on
Low mood Worth acting on
A severe allergic reaction Worth acting on
An allergic reaction Worth acting on
Stomach pain
Diarrhea
Vomiting
Headache
Nausea

From the ADVERSE REACTIONS section of the FDA label for Setmelanotide. Read the label on DailyMed › American Ivy’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no American Ivy side to compare — that is a limit of the record, not a statement that American Ivy has no side effects.

How much people look this up

Where American Ivy and Setmelanotide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement American Ivy

Steady interest

#987 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Setmelanotide

Top half

#980 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. American Ivy is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every American Ivy reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The American Ivy and Setmelanotide records this page draws on were last updated June 22, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About American Ivy

What is American Ivy?

Digestive upset
To stimulate sweating
Traditional tonic use
Skin and swelling complaints (topical folk use)

American Ivy (Virginia creeper) is mainly an ornamental climbing vine with a long history of folk use for digestion and sweating, but there is very little human evidence to support any health benefit. Its berries contain oxalic acid and are considered poisonous, and the plant can irritate the skin. Because safety data is limited, talk with your pharmacist or doctor before using it.

Parthenocissus quinquefolia · Vitaceae · Bark, leaves, and stems (berries are considered poisonous) · Dried bark, tinctures, teas; rarely sold as a standardized supplement

An interaction check asks whether these two react with each other — it does not ask whether American Ivy is a good idea for someone in your situation. Here is what our American Ivy record says about it on its own.

American Ivy: dosing

There is no established safe or effective dose for American Ivy. It is not a standardized supplement, so the strength of any product can vary a lot.If you choose to use a product that contains it, follow the directions on the label and do not exceed them. Never make a home preparation from the raw plant or its berries.

From our American Ivy monograph — the full record covers uses, side effects and every documented interaction.

Read the full American Ivy monograph & all interactions

Medication

About Setmelanotide Injection

What Is Setmelanotide Injection Used For?

Brand name: Imcivree

Imcivree is used to reduce excess body weight and maintain that weight loss long-term in adults and children with certain rare, specific causes of obesity. It is not intended for general weight loss or common obesity.

Imcivree is approved for: acquired hypothalamic obesity (HO) in patients aged 4 and older; Bardet-Biedl syndrome (BBS) in patients aged 2 and older; and obesity caused by confirmed deficiencies of POMC, PCSK1, or LEPR genes (pathogenic, likely pathogenic, or uncertain-significance variants) in patients aged 2 and older.

See full Setmelanotide Injection drug information

Keep checking

Other Drugs & American Ivy

Browse every other medication we’ve checked against American Ivy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

56Moderate

0Minor

2,773No known interaction

56 Moderate 2,773 No interaction

Moderate

56 interactions

No interaction 2,773 drugs checked — show the list

We also checked American Ivy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,773 medications checked with no known interaction — see the full American Ivy list.

See the full American Ivy interactions page

See every supplement checked against Setmelanotide, ranked by severity

Evidence & sources

American Ivy References

The 1 sources that drive our American Ivy monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. American Ivy is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

Oxalates — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking American Ivy and Setmelanotide Together: Common Questions

Is it safe to take American Ivy with Setmelanotide?

We do not list a known interaction between American Ivy and Setmelanotide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Does American Ivy interact with any other medications?

Yes. American Ivy has 56 documented drug interactions in our database — Setmelanotide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

American Ivy monograph Uses, safety profile, and every drug interaction in one place Setmelanotide Injection drug information The full plain-English guide to this medication Setmelanotide supplement interactions Every supplement checked against Setmelanotide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Setmelanotide and American Ivy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.