Drug & supplement interaction

American Ivy + Bupropion

Bupropion brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between American Ivy and Bupropion in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

American Ivy and Bupropion

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bupropion and American Ivy in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

American Ivy safety at a glance

American Ivy overall Use caution Little safety data exists, and the berries are toxic, so use it cautiously and avoid eating any part of the plant.
Pregnancy Avoid There is not enough safety information, so it is best to avoid use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoiding it is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bupropion and American Ivy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Bupropion

Interactions in our licensed database are recorded against drug classes, not just single drug names. Bupropion is filed under 6 classifications — including antidepressant drugs, cytochrome p450 2b6 (cyp2b6) substrates, cytochrome p450 2d6 (cyp2d6) inhibitors. American Ivy has documented interactions with 1 drug class — the most serious being thiazide diuretics (moderate) — and none of Bupropion’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

American Ivy Does Interact With Other Medications

American Ivy has 56 moderate known drug interactions in our database — Bupropion isn’t one of them. If you take anything else, check it against the full list below.

Moderate 56 No known interaction 2,774 (incl. Bupropion)
Taking anything else?

Check Another of Your Medications Against American Ivy

Covers the 2,830 medications we’ve checked against American Ivy. Pick one to open its full report.

What to actually watch for

What Bupropion’s Own FDA Label Lists

This is not an interaction — none of it involves American Ivy. These are the most notable effects listed in the ADVERSE REACTIONS section of Bupropion’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Mania or an unusually elevated mood Worth acting on
  • Thoughts of self-harm Worth acting on
  • Trouble swallowing Worth acting on
  • Hallucinations Worth acting on
  • An irregular heartbeat Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • Chest pain Worth acting on
  • Raised blood pressure Worth acting on
  • Hives Worth acting on

Showing the 10 most notable of 43 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Bupropion. Read the label on DailyMed › Where a percentage is shown, it is the share of 152,137 voluntary FDA FAERS reports for Bupropion that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. American Ivy’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no American Ivy side to compare — that is a limit of the record, not a statement that American Ivy has no side effects.

From our Q&A

Questions About American Ivy or Bupropion

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers American Ivy or Bupropion, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Bupropion

This page covers American Ivy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bupropion page lists 46 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), African Wild Potato (moderate), Artichoke (moderate) and Astaxanthin (moderate).

By severity: 1 major · 33 moderate · 12 minor.

From our pharmacist’s overview on the Bupropion page

“Bupropion (Wellbutrin, Zyban) deserves genuine care around supplements, and the entry to understand first is activated charcoal, the only major-rated interaction on this list. Charcoal and similar bulk products can soak up the drug in the gut and blunt its effect, so space them well apart from your dose.”

Reviewed by 2 · Jul 18, 2026

Open the Bupropion interaction page

How much people look this up

Where American Ivy and Bupropion Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement American Ivy
Steady interest

#1,143 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bupropion
Top 1%

#23 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. American Ivy is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every American Ivy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The American Ivy and Bupropion records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About American Ivy

What is American Ivy?

American Ivy
  • Digestive upset
  • To stimulate sweating
  • Traditional tonic use
  • Skin and swelling complaints (topical folk use)

American Ivy (Virginia creeper) is mainly an ornamental climbing vine with a long history of folk use for digestion and sweating, but there is very little human evidence to support any health benefit. Its berries contain oxalic acid and are considered poisonous, and the plant can irritate the skin. Because safety data is limited, talk with your pharmacist or doctor before using it.

Parthenocissus quinquefolia · Vitaceae · Bark, leaves, and stems (berries are considered poisonous) · Dried bark, tinctures, teas; rarely sold as a standardized supplement

An interaction check asks whether these two react with each other — it does not ask whether American Ivy is a good idea for someone in your situation. Here is what our American Ivy record says about it on its own.

American Ivy: dosing

There is no established safe or effective dose for American Ivy. It is not a standardized supplement, so the strength of any product can vary a lot.If you choose to use a product that contains it, follow the directions on the label and do not exceed them. Never make a home preparation from the raw plant or its berries.

From our American Ivy monograph — the full record covers uses, side effects and every documented interaction.

Read the full American Ivy monograph & all interactions
Medication

About Bupropion

What Is Bupropion Used For?

Brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, Forfivo XL

Bupropion is FDA-approved to treat major depressive disorder (MDD) — a form of clinical depression. Extended-release formulations (XL and hydrobromide versions, including Aplenzin) are also approved for the prevention of seasonal affective disorder (SAD), the pattern of depression that tends to arrive in autumn and winter.

Not all formulations share every indication. Aplenzin (bupropion hydrobromide extended-release) and bupropion hydrochloride extended-release tablets (XL) are indicated for both MDD and SAD. Bupropion hydrochloride extended-release tablets (SR) and bupropion hydrochloride immediate-release tablets are indicated for MDD only.

Most-Reported Side Effects for Bupropion

From FAERS, the FDA’s public side-effect reporting system (152,137 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 11,909 reports
Fatigue 10,076 reports
Headache 10,053 reports
Depression 8,639 reports
Dizziness 7,786 reports
See full Bupropion drug information
Keep checking

Other Drugs & American Ivy

Browse every other medication we’ve checked against American Ivy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
56Moderate
0Minor
2,773No known interaction
56 Moderate 2,773 No interaction
Moderate

56 interactions

No interaction 2,773 drugs checked — show the list

We also checked American Ivy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,773 medications checked with no known interaction — see the full American Ivy list.

See the full American Ivy interactions page
See every supplement checked against Bupropion, ranked by severity
Evidence & sources

American Ivy References

The 1 sources that drive our American Ivy monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. American Ivy is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Oxalates — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking American Ivy and Bupropion Together: Common Questions

Is it safe to take American Ivy with Bupropion?
We do not list a known interaction between American Ivy and Bupropion. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the American Ivy and Bupropion combination checked?
Interactions in our licensed database are recorded against drug classes. Bupropion is filed under 6 classifications, and American Ivy has documented interactions with 1 drug class — none of Bupropion's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does American Ivy interact with any other medications?
Yes. American Ivy has 56 documented drug interactions in our database — Bupropion is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Bupropion interact with any supplements?
Yes. Bupropion has documented interactions with 46 supplements in our database — American Ivy is not one of them. The Bupropion interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

American Ivy monograph Uses, safety profile, and every drug interaction in one place Bupropion drug information The full plain-English guide to this medication Bupropion supplement interactions Every supplement checked against Bupropion, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Bupropion and American Ivy?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.