Drug & supplement interaction

Androstenetrione + Betamethasone

Betamethasone brand names: Celestone, Diprolene AF, Diprosone.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Androstenetrione and Betamethasone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Androstenetrione and Betamethasone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Betamethasone and Androstenetrione in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Androstenetrione safety at a glance

Androstenetrione overall Use caution Limited safety data and hormone-related side effects make this a risky supplement.
Pregnancy Possibly Unsafe When used orally. There is no scientifically reliable information about using androstenetrione during pregnancy or lactation. Promoters indicate that it can inc... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. There is no scientifically reliable information about using androstenetrione during pregnancy or lactation. Promoters indicate that it can inc... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Betamethasone and Androstenetrione? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Betamethasone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Betamethasone is filed under 5 classifications — including corticosteroids, immunosuppressants, topical drugs. Androstenetrione has documented interactions with 1 drug class — the most serious being androgens (minor) — and none of Betamethasone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Androstenetrione Does Interact With Other Medications

Androstenetrione has 9 minor known drug interactions in our database — Betamethasone isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Androstenetrione

Covers the 2,830 medications we’ve checked against Androstenetrione. Pick one to open its full report.

What to actually watch for

What Androstenetrione Itself Has Been Linked To

This is not an interaction — nothing below involves Betamethasone. It is the side-effect record for Androstenetrione on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Androstenetrione, this list is the first place to look.

  • Breast tenderness / Acne Additional detail

    “There is no data regarding oral use of androstenetrione in humans. However, androstenetrione might increase testosterone levels. Theoretically, androstenetrione might cause testosterone-like side effects including spermatogenesis and infertility, acne, testicular atrophy, gynecomastia, behavioral changes, cardiovascular disease, and potentially increase the risk of pancreatic and prostate cancer.”

    Androstenetrione · Natural Medicines adverse-effect record, reported in acne.

Everything above comes from the Natural Medicines adverse-effect record for Androstenetrione — expand a row for the licensed statement it rests on. We haven’t matched Betamethasone to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Betamethasone.

Special populations

Androstenetrione in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. There is no scientifically reliable information about using androstenetrione during pregnancy or lactation. Promoters indicate that it can increase testosterone levels. If this is true, this product may not be safe due to the adverse effects associated with elevated testosterone levels; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Betamethasone

This page covers Androstenetrione only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Betamethasone page lists 124 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lily-of-the-valley (major), St. John's Wort (major), Active Hexose Correlated Compound (ahcc) (moderate) and Alder Buckthorn (moderate).

By severity: 3 major · 102 moderate · 19 minor.

From our pharmacist’s overview on the Betamethasone page

“Betamethasone (Celestone, Diprolene) works by quieting the immune system, which is exactly why this list warrants a slow, careful read. More than fifty of the ingredients here are immune stimulants that can push back against the steroid, and another sizable group changes how much of the drug the body absorbs or holds onto.”

Reviewed by 2 · Jul 18, 2026

Open the Betamethasone interaction page

One more smart check

Taking Androstenetrione as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Androstenetrione, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Androstenetrione. Even though Androstenetrione itself has no known interaction with Betamethasone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Androstenetrione and Betamethasone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Androstenetrione
Top half

#710 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Betamethasone
Top half

#1,309 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Androstenetrione is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Androstenetrione reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Androstenetrione and Betamethasone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Androstenetrione

What is Androstenetrione?

Androstenetrione
  • Boosting testosterone
  • Lowering estrogen
  • Bodybuilding and muscle building
  • Post-cycle support for steroid users
  • Athletic performance

Androstenetrione (6-OXO) is a synthetic compound marketed to raise testosterone by blocking the enzyme that turns testosterone into estrogen. Solid human evidence that it offers real benefits is lacking, and it can cause hormone-related side effects, so most people should avoid it and talk with a healthcare provider first.

Synthetic compound (not from a plant) · Capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Androstenetrione is a good idea for someone in your situation. Here is what our Androstenetrione record says about it on its own.

Androstenetrione: dosing

There is no established, standardized dose for androstenetrione, and no dose has been proven safe and effective. Different products contain different amounts.Because of the hormone-related risks and weak evidence, we cannot recommend a specific amount.

From our Androstenetrione monograph — the full record covers uses, side effects and every documented interaction.

Read the full Androstenetrione monograph & all interactions
Medication

About Betamethasone Topical

What Is Betamethasone Topical Used For?

Brand names: Celestone, Diprolene AF, Diprosone

Betamethasone topical is used to relieve the redness, swelling, and itching of corticosteroid-responsive dermatoses (skin conditions that respond to steroid treatment). Sernivo Spray is specifically approved for plaque psoriasis of the body. Diprolene (topical cream, ointment, or gel) is indicated for inflammatory and itchy skin conditions in patients 13 years of age and older.

This medication is for use on the skin only. It is not approved for use on the face, groin, or underarms, and it is not for use in the eyes, mouth, or vagina.

Most-Reported Side Effects for Betamethasone

From FAERS, the FDA’s public side-effect reporting system (14,342 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Psoriasis 1,328 reports
Nausea 1,024 reports
Pruritus 962 reports
Headache 898 reports
Rash 862 reports
See full Betamethasone Topical drug information
Keep checking

Other Drugs & Androstenetrione

Browse every other medication we’ve checked against Androstenetrione — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
9Minor
2,820No known interaction
Minor

9 interactions

No interaction 2,820 drugs checked — show the list
Evidence & sources

Androstenetrione References

The 3 sources that drive our Androstenetrione monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Androstenetrione is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  3. Herbs at a Glance — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Androstenetrione and Betamethasone Together: Common Questions

Is it safe to take Androstenetrione with Betamethasone?
We do not list a known interaction between Androstenetrione and Betamethasone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Androstenetrione and Betamethasone combination checked?
Interactions in our licensed database are recorded against drug classes. Betamethasone is filed under 5 classifications, and Androstenetrione has documented interactions with 1 drug class — none of Betamethasone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Androstenetrione interact with any other medications?
Yes. Androstenetrione has 9 documented drug interactions in our database — Betamethasone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Betamethasone interact with any supplements?
Yes. Betamethasone has documented interactions with 124 supplements in our database — Androstenetrione is not one of them. The Betamethasone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Betamethasone and Androstenetrione?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.