Angostura + Lomitapide
Lomitapide brand name: Juxtapid.
We found no known interaction between Angostura and Lomitapide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Angostura and Lomitapide
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Lomitapide and Angostura in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Angostura at all — not against Lomitapide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Angostura safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Lomitapide
This page covers Angostura only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lomitapide page lists 168 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 6 major · 124 moderate · 38 minor.
From our pharmacist’s overview on the Lomitapide page
“If you take lomitapide (Juxtapid) for homozygous familial hypercholesterolemia, treat this page with real care. Lomitapide is cleared by one liver enzyme, CYP3A4, and 121 of the 168 supplements here can push its blood level up or down through that pathway; grapefruit and St.”
Reviewed by 2 · Jul 18, 2026
Taking Angostura as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1 real supplement products containing Angostura, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Angostura. Even though Angostura itself has no known interaction with Lomitapide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Angostura and Lomitapide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,174 of 1,452 supplements looked up here in the last 7 days
#1,703 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Angostura reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Angostura and Lomitapide records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Angostura
What is Angostura?
- Digestive upset and poor appetite
- Fever
- Diarrhea
- Malaria prevention (traditional)
- Muscle spasms
Angostura is the bark of a South American tree traditionally used to ease digestion, fevers, and stomach problems. Modern human evidence to support these uses is very limited, and large doses can cause vomiting and other harmful effects. It is best known today as a historic flavoring ingredient, and you should talk with a pharmacist or doctor before using it medicinally.
Angostura trifoliata · Rutaceae · Bark · Bark powder, tincture, extract, and as a flavoring in some alcoholic beverages
An interaction check asks whether these two react with each other — it does not ask whether Angostura is a good idea for someone in your situation. Here is what our Angostura record says about it on its own.
Angostura: dosing
There is no well-established, standardized medicinal dose for angostura. Traditional uses vary widely, and there is not enough reliable research to recommend a safe and effective amount.If you choose to use a product that contains angostura, follow the directions on the product label and do not exceed them, since larger amounts can cause vomiting and diarrhea.
From our Angostura monograph — the full record covers uses, side effects and every documented interaction.
About Lomitapide
What Is Lomitapide Used For?
Brand name: Juxtapid
Juxtapid (lomitapide) is used alongside a low-fat diet and other cholesterol-lowering treatments — including LDL apheresis (a procedure that filters LDL from the blood) where available — to lower LDL cholesterol, total cholesterol, apolipoprotein B, and non-HDL cholesterol in patients with homozygous familial hypercholesterolemia (HoFH). HoFH is a rare, inherited condition that causes extremely high LDL cholesterol levels from birth.
Juxtapid is approved for use in adults and in children aged 2 years and older with HoFH. It has not been proven safe or effective for other types of high cholesterol, including the more common heterozygous familial hypercholesterolemia (HeFH). Its effect on heart attacks, strokes, or other cardiovascular events has not been established.
Other Drugs & Angostura
Browse every other medication we’ve checked against Angostura — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Angostura against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Lisinopril ›
- Amoxicillin ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Angostura list.
Angostura References
The 2 references that drive our Angostura monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Angostura and Lomitapide Together: Common Questions
Is it safe to take Angostura with Lomitapide?
Do Angostura and Lomitapide have any of the same side effects?
Does Lomitapide interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.