Drug & supplement interaction

Aquatic Exercise + Pregabalin

Pregabalin brand names: Lyrica, Lyrica CR.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Aquatic Exercise and Pregabalin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Aquatic Exercise and Pregabalin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pregabalin and Aquatic Exercise in our sources. This does not guarantee that the combination is completely free of risk — research on Aquatic Exercise alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Aquatic Exercise at all — not against Pregabalin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Aquatic Exercise is a practice rather than something you take. Ask your care team whether the type and intensity you plan to practice are appropriate for your health and treatment. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Aquatic Exercise safety at a glance

Aquatic Exercise overall Generally safe For most people, water-based exercise is a low-impact and safe form of activity.

Pregnancy Possibly Safe When conducted appropriately, short-term. Clinical research suggests that aquatic exercise is safe during pregnancy when conducted at temperatures ranging from... Read the full pregnancy detail

Breastfeeding Generally safe Aquatic exercise is generally compatible with breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pregabalin and Aquatic Exercise? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

What to actually watch for

No Interaction Found — But Data Suggests Aquatic Exercise and Pregabalin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so practicing Aquatic Exercise while taking the medicine can make those effects more likely to turn up, and harder to pin on one or the other if they do.

Muscle pain Additional detail
Aquatic Exercise
“Aquatic exercise is generally well-tolerated when used appropriately, short-term. Aquatic exercise has been performed for up to 12 weeks without reports of serious adverse effects. Mild adverse effects including dizziness, fatigue, and musculoskeletal pain have been reported, but these are uncommon.”

Aquatic Exercise · Natural Medicines adverse-effect record, reported in fatigue.
2 sources cited

96598. Adsett JA, Mudge AM, Morris N, Kuys S, Paratz JD. Aquatic exercise training and stable heart failure: A systematic review and meta-analysis. Int J Cardiol. 2015;186:22-8. PubMed

96599. Bartels EM, Juhl CB, Christensen R, et al. Aquatic exercise for the treatment of knee and hip osteoarthritis. Cochrane Database Syst Rev. 2016;3:CD005523. PubMed
“Aquatic exercise has been rarely associated with new cases of mild musculoskeletal pain.”

Aquatic Exercise · Natural Medicines adverse-effect record, reported in pain.
2 sources cited

96599. Bartels EM, Juhl CB, Christensen R, et al. Aquatic exercise for the treatment of knee and hip osteoarthritis. Cochrane Database Syst Rev. 2016;3:CD005523. PubMed

108281. Peng MS, Wang R, Wang YZ, et al. Efficacy of therapeutic aquatic exercise vs physical therapy modalities for patients with chronic low back pain: A randomized clinical trial. JAMA Netw Open 2022;5(1):e2142069. PubMed
Pregabalin

Listed in the ADVERSE REACTIONS section of the FDA label for Pregabalin. Read the label on DailyMed ›
Tiredness / Dizziness Additional detail
Aquatic Exercise
“Aquatic exercise has been rarely associated with dizziness and fatigue.”

Aquatic Exercise · Natural Medicines adverse-effect record, reported in fatigue.
2 sources cited

96598. Adsett JA, Mudge AM, Morris N, Kuys S, Paratz JD. Aquatic exercise training and stable heart failure: A systematic review and meta-analysis. Int J Cardiol. 2015;186:22-8. PubMed

96599. Bartels EM, Juhl CB, Christensen R, et al. Aquatic exercise for the treatment of knee and hip osteoarthritis. Cochrane Database Syst Rev. 2016;3:CD005523. PubMed
Pregabalin

Listed in the ADVERSE REACTIONS section of the FDA label for Pregabalin. Read the label on DailyMed ›

Effects for Pregabalin come from the ADVERSE REACTIONS section of its FDA label; effects for Aquatic Exercise come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Aquatic Exercise in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When conducted appropriately, short-term. Clinical research suggests that aquatic exercise is safe during pregnancy when conducted at temperatures ranging from 28.8-33.4℃ (83.8-92.1℉) for up to 45 minutes.

Pregnancy Possibly Unsafe

When heated aquatic exercise is used. Conditions that increase maternal core temperature above 39℃ have been associated with increased risk of teratogenicity. Some early research also found an association between maternal heat exposure in the form of a hot tub or sauna during the first trimester and increased risk of neural tube defects. A more recent analysis of clinical research shows that it is safe to sit in hot baths at 40℃ (104℉) or in saunas at 70℃ (158℉) for up to 20 minutes during pregnancy, regardless of trimester. However, the ACOG clinical practice guidelines continue to discourage hot water baths or saunas during pregnancy due to possible risks. LACTACTION: Insufficient reliable information available; however, there is no known reason to expect any adverse effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Pregabalin Is Prescribed For, and What Aquatic Exercise Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Pregabalin is a prescription medicine with approved uses on its FDA label. Aquatic Exercise is a practice: what follows is what researchers have looked at it for, and how strong that evidence is.

Pregabalin is prescribed for: Pregabalin is used to manage several types of nerve pain, including neuropathic pain from diabetic peripheral neuropathy (nerve damage caused by diabetes) and postherpetic neuralgia (lingering nerve pain after shingles). It is also used to treat fibromyalgia and neuropathic pain associated with spinal cord injury. Lyrica (capsule and oral solution), pregabalin capsules, and pregabalin oral solution are also approved as add-on therapy for partial-onset seizures — Lyrica for patients 1 month and older, and pregabalin capsules for patients 17 years and older. Lyrica CR and pregabalin extended-release tablets are approved only for diabetic peripheral neuropathy pain and postherpetic neuralgia — their effectiveness for fibromyalgia or as seizure add-on therapy has not been established.

Aquatic Exercise has been studied for:

Fibromyalgia studied, not established Aquatic Exercise has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Aquatic Exercise for fibromyalgia
A small clinical study in women with fibromyalgia shows that stretching, relaxation, and aquatic exercise for 1 hour three times weekly for 3 weeks improves sleep but not quality of life compared to the same exercises on land.
1 source cited

27783. Vitorino, D. F., Carvalho, L. B., and Prado, G. F. Hydrotherapy and conventional physiotherapy improve total sleep time and quality of life of fibromyalgia patients: randomized clinical trial. Sleep Med 2006;7(3):293-296. PubMed
Diabetes studied, not established Aquatic Exercise has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Aquatic Exercise for diabetes
A meta-analysis of preliminary clinical and observational research in patients with type 2 diabetes has found that aquatic exercise modestly increases the maximal oxygen uptake and reduces resting heart rate when compared with baseline and control groups receiving no intervention. However, a sub-analysis found that aquatic exercise is no more beneficial than land exercise.
1 source cited

108290. Zhu H, Jin J, Zhao G. Effect of aquatic exercise on cardiovascular fitness in people with type 2 diabetes mellitus: a systematic review and meta-analysis. Kardiologiia 2021;61(9):52-60. PubMed

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Pregabalin on your own; if you are taking Aquatic Exercise for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Aquatic Exercise or Pregabalin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Aquatic Exercise or Pregabalin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Pregabalin

This page covers Aquatic Exercise only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pregabalin page lists 95 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 73 moderate · 15 minor.

From our pharmacist’s overview on the Pregabalin page

“Pregabalin (Lyrica) calms overactive nerves, which is how it eases nerve pain, seizures, and anxiety, and that calming action stacks with almost everything on this list. Of the 95 supplements and herbs, the large majority add their own sedation on top of pregabalin's, and a few can tip that into genuine danger, with deep sedation and s…”

Reviewed by 2 · Jul 18, 2026

Open the Pregabalin interaction page

How much people look this up

Where Aquatic Exercise and Pregabalin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Aquatic Exercise

Top half

#713 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Pregabalin

Top 5%

#39 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Aquatic Exercise reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Aquatic Exercise and Pregabalin records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Mind-body practice

About Aquatic Exercise

What is Aquatic Exercise?

Arthritis and joint pain
Low back pain
Fibromyalgia
Balance and fall prevention
General fitness and weight management
Rehabilitation after injury or surgery

Aquatic exercise is physical activity done in water, such as water aerobics, lap swimming, or pool-based physical therapy. The buoyancy of water reduces stress on joints, making it a gentle, generally safe way to build strength, flexibility, and fitness, especially for people with arthritis or chronic pain. Check with your doctor before starting if you have heart, lung, or balance problems.

Water aerobics, aquatic physical therapy, swimming, deep-water running, hydrotherapy classes

An interaction check asks whether these two react with each other — it does not ask whether Aquatic Exercise is a good idea for someone in your situation. Here is what our Aquatic Exercise record says about it on its own.

Aquatic Exercise: dosing

There is no single "dose" for aquatic exercise. General fitness guidelines suggest aiming for about 150 minutes of moderate activity per week, which can include water-based sessions, but your ideal amount depends on your health and goals.Many programs run two to three sessions per week. If you are recovering from injury or have a chronic condition, a physical therapist or your doctor can help set a safe starting point and progress you gradually.Start slowly, warm up, stay hydrated even in the water, and stop if you feel pain beyond normal muscle effort.

From our Aquatic Exercise monograph — the full record covers uses, side effects and every documented interaction.

Read the full Aquatic Exercise monograph & all interactions

Medication

About Pregabalin

What Is Pregabalin Used For?

Brand names: Lyrica, Lyrica CR

Pregabalin is used to manage several types of nerve pain, including neuropathic pain from diabetic peripheral neuropathy (nerve damage caused by diabetes) and postherpetic neuralgia (lingering nerve pain after shingles). It is also used to treat fibromyalgia and neuropathic pain associated with spinal cord injury.

Lyrica (capsule and oral solution), pregabalin capsules, and pregabalin oral solution are also approved as add-on therapy for partial-onset seizures — Lyrica for patients 1 month and older, and pregabalin capsules for patients 17 years and older. Lyrica CR and pregabalin extended-release tablets are approved only for diabetic peripheral neuropathy pain and postherpetic neuralgia — their effectiveness for fibromyalgia or as seizure add-on therapy has not been established.

Most-Reported Side Effects for Pregabalin

From FAERS, the FDA’s public side-effect reporting system (270,557 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 15,629 reports

Dizziness 14,844 reports

Nausea 14,507 reports

Headache 13,067 reports

Malaise 12,884 reports

See full Pregabalin drug information

Keep checking

Other Drugs & Aquatic Exercise

Browse every other medication we’ve checked against Aquatic Exercise — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

0Minor

2,829No known interaction

2,829 No interaction

No interaction 2,829 drugs checked — show the list

We also checked Aquatic Exercise against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Aquatic Exercise list.

See the full Aquatic Exercise interactions page

See every supplement checked against Pregabalin, ranked by severity

Evidence & sources

Aquatic Exercise References

The 49 references that drive our Aquatic Exercise monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Sjogren, T., Long, N., Storay, I., and Smith, J. Group hydrotherapy versus group land-based treatment for chronic low back pain. Physiother Res Int 1997;2(4):212-222. PubMed
Stener-Victorin, E., Kruse-Smidje, C., and Jung, K. Comparison between electro-acupuncture and hydrotherapy, both in combination with patient education and patient education alone, on the symptomatic treatment of osteoarthritis of the hip. Clin J Pain 200 PubMed
Foley, A., Halbert, J., Hewitt, T., and Crotty, M. Does hydrotherapy improve strength and physical function in patients with osteoarthritis--a randomised controlled trial comparing a gym based and a hydrotherapy based strengthening programme. Ann Rheum Di PubMed
Eversden, L., Maggs, F., Nightingale, P., and Jobanputra, P. A pragmatic randomised controlled trial of hydrotherapy and land exercises on overall well being and quality of life in rheumatoid arthritis. BMC Musculoskelet Disord 2007;8:23. PubMed
Hall, J., Skevington, S. M., Maddison, P. J., and Chapman, K. A randomized and controlled trial of hydrotherapy in rheumatoid arthritis. Arthritis Care Res 1996;9(3):206-215. PubMed
Wadell, K., Sundelin, G., Henriksson-Larsen, K., and Lundgren, R. High intensity physical group training in water--an effective training modality for patients with COPD. Respir Med 2004;98(5):428-438. PubMed
Vitorino, D. F., Carvalho, L. B., and Prado, G. F. Hydrotherapy and conventional physiotherapy improve total sleep time and quality of life of fibromyalgia patients: randomized clinical trial. Sleep Med 2006;7(3):293-296. PubMed
Cider, A., Sunnerhagen, K. S., Schaufelberger, M., and Andersson, B. Cardiorespiratory effects of warm water immersion in elderly patients with chronic heart failure. Clin Physiol Funct Imaging 2005;25(6):313-317. PubMed
Rush, J., Burlock, S., Lambert, K., Loosley-Millman, M., Hutchison, B., and Enkin, M. The effects of whirlpools baths in labor: a randomized, controlled trial. Birth 1996;23(3):136-143.
Cammu, H., Clasen, K., Van, Wettere L., and Derde, M. P. 'To bathe or not to bathe' during the first stage of labor. Acta Obstet Gynecol Scand 1994;73(6):468-472. PubMed
Eckert, K., Turnbull, D., and MacLennan, A. Immersion in water in the first stage of labor: a randomized controlled trial. Birth 2001;28(2):84-93. PubMed
Eriksson, M., Mattsson, L. A., and Ladfors, L. Early or late bath during the first stage of labour: a randomised study of 200 women. Midwifery 1997;13(3):146-148. PubMed
Lenstrup, C., Schantz, A., Berget, A., Feder, E., Roseno, H., and Hertel, J. Warm tub bath during delivery. Acta Obstet Gynecol Scand 1987;66(8):709-712. PubMed
Cunha, M. C., Oliveira, A. S., Labronici, R. H., and Gabbai, A. A. Spinal muscular atrophy type II (intermediary) and III (Kugelberg-Welander). Evolution of 50 patients with physiotherapy and hydrotherapy in a swimming pool. Arq Neuropsiquiatr 1996;54(3): PubMed
Driver, S., Rees, K., O'Connor, J., and Lox, C. Aquatics, health-promoting self-care behaviours and adults with brain injuries. Brain Inj 2006;20(2):133-141. PubMed
Fransen, M., Nairn, L., Winstanley, J., Lam, P., and Edmonds, J. Physical activity for osteoarthritis management: a randomized controlled clinical trial evaluating hydrotherapy or Tai Chi classes. Arthritis Rheum 2007;57(3):407-414. PubMed
Ravanelli N, Casasola W, English T, Edwards KM, Jay O. Heat stress and fetal risk. Environmental limits for exercise and passive heat stress during pregnancy: a systematic review with best evidence synthesis. Br J Sports Med. 2018;0:1-8. PubMed
Milunsky A, Ulcickas M, Rothman KJ, et al. Maternal heat exposure and neural tube defects. JAMA. 1992;268(7):882-5. DOI
[No authors listed]. ACOG Committee Opinion No. 650: physical activity and exercise during pregnancy and the postpartum period. Obstet Gynecol 2015;126:e135-42. PubMed
Adsett JA, Mudge AM, Morris N, Kuys S, Paratz JD. Aquatic exercise training and stable heart failure: A systematic review and meta-analysis. Int J Cardiol. 2015;186:22-8. PubMed
Bartels EM, Juhl CB, Christensen R, et al. Aquatic exercise for the treatment of knee and hip osteoarthritis. Cochrane Database Syst Rev. 2016;3:CD005523. PubMed
Carroll LM, Volpe D, Morris ME, Saunders J, Clifford AM. Aquatic Exercise Therapy for People With Parkinson Disease: A Randomized Controlled Trial. Arch Phys Med Rehabil. 2017;98(4):631-638. PubMed
Heywood S, McClelland J, Mentiplay B, Geigle P, Rahmann A, Clark R. Effectiveness of Aquatic Exercise in Improving Lower Limb Strength in Musculoskeletal Conditions: A Systematic Review and Meta-Analysis. Arch Phys Med Rehabil. 2017;98(1):173-186. PubMed
Lai CJ, Liu WY, Yang TF, Chen CL, Wu CY, Chan RC. Pediatric aquatic therapy on motor function and enjoyment in children diagnosed with cerebral palsy of various motor severities. J Child Neurol. 2015;30(2):200-8. PubMed
Neto MG, Conceição CS, de Jesus FL, Oliveira Carvalho V. Hydrotherapy on exercise capacity, muscle strength and quality of life in patients with heart failure: A meta-analysis. Int J Cardiol. 2015;198:216-9. PubMed
Palamara G, Gotti F, Maestri R, et al. Land Plus Aquatic Therapy Versus Land-Based Rehabilitation Alone for the Treatment of Balance Dysfunction in Parkinson Disease: A Randomized Controlled Study With 6-Month Follow-Up. Arch Phys Med Rehabil. 2017;98(6): PubMed
Zhu Z, Cui L, Yin M, et al. Hydrotherapy vs. conventional land-based exercise for improving walking and balance after stroke: a randomized controlled trial. Clin Rehabil. 2016;30(6):587-93. PubMed
Dong R, Wu Y, Xu S, et al. Is aquatic exercise more effective than land-based exercise for knee osteoarthritis? Medicine (Baltimore). 2018;97(52):e13823. PubMed
Felcar JM, Probst VS, de Carvalho DR, et al. Effects of exercise training in water and on land in patients with COPD: a randomised clinical trial. Physiotherapy. 2018;104(4):408-416. PubMed
Igarashi Y, Nogami Y. The effect of regular aquatic exercise on blood pressure: A meta-analysis of randomized controlled trials. Eur J Prev Cardiol. 2018;25(2):190-199. PubMed
Saquetto MB, da Silva CM, Martinez BP, et al. Water-Based Exercise on Functioning and Quality of Life in Poststroke Persons: A Systematic Review and Meta-Analysis. J Stroke Cerebrovasc Dis. 2019;28(11):104341. PubMed
Shi Z, Zhou H, Lu L, et al. Aquatic Exercises in the Treatment of Low Back Pain: A Systematic Review of the Literature and Meta-Analysis of Eight Studies. Am J Phys Med Rehabil. 2018;97(2):116-122. PubMed
Silva LAD, Tortelli L, Motta J, et al. Effects of aquatic exercise on mental health, functional autonomy and oxidative stress in depressed elderly individuals: A randomized clinical trial. Clinics (Sao Paulo). 2019;74:e322. PubMed
Yeung W, Semciw AI. Aquatic Therapy for People with Lymphedema: A Systematic Review and Meta-analysis. Lymphat Res Biol. 2018;16(1):9-19. PubMed
Peng MS, Wang R, Wang YZ, et al. Efficacy of therapeutic aquatic exercise vs physical therapy modalities for patients with chronic low back pain: A randomized clinical trial. JAMA Netw Open 2022;5(1):e2142069. PubMed
Amedoro A, Berardi A, Conte A, et al. The effect of aquatic physical therapy on patients with multiple sclerosis: A systematic review and meta-analysis. Mult Scler Relat Disord 2020;41:102022. PubMed
Giuriati S, Servadio A, Temperoni G, Curcio A, Valente D, Galeoto G. The effect of aquatic physical therapy in patients with stroke: A systematic review and meta-analysis. Top Stroke Rehabil 2021;28(1):19-32. PubMed
Kim JH, Ha MS, Ha SM, Kim DY. Aquatic exercise positively affects physiological frailty among postmenopausal women: A randomized controlled clinical trial. Healthcare (Basel) 2021;9(4):409. PubMed
Lee CH, Kim IH. Aquatic exercise and land exercise treatments after total knee replacement arthroplasty in elderly women: A comparative study. Medicina (Kaunas) 2021;57(6):589. PubMed
Gomes Neto M, Pontes SS, Almeida LO, da Silva CM, da Conceição Sena C, Saquetto MB. Effects of water-based exercise on functioning and quality of life in people with Parkinson's disease: a systematic review and meta-analysis. Clin Rehabil 2020;34(12):1425 PubMed
Li D, Chen P. Effects of aquatic exercise and land-based exercise on cardiorespiratory fitness, motor function, balance, and functional independence in stroke patients-A meta-analysis of randomized controlled trials. Brain Sci 2021;11(8):1097. PubMed
So BCL, Kwok SC, Lee PH. Effect of aquatic exercise on sleep efficiency of adults with chronic musculoskeletal pain. J Phys Act Health 2021;18(9):1037-1045. PubMed
Zhu H, Jin J, Zhao G. Effect of aquatic exercise on cardiovascular fitness in people with type 2 diabetes mellitus: a systematic review and meta-analysis. Kardiologiia 2021;61(9):52-60. PubMed
Moreira NB, da Silva LP, Rodacki ALF. Aquatic exercise improves functional capacity, perceptual aspects, and quality of life in older adults with musculoskeletal disorders and risk of falling: A randomized controlled trial. Exp Gerontol 2020;142:111135. PubMed
Carrascosa MDC, Navas A, Artigues C, et al. Effect of aerobic water exercise during pregnancy on epidural use and pain: A multi-centre, randomised, controlled trial. Midwifery 2021;103:103105. PubMed
Abadi FH, Sankaravel M, Zainuddin FF, Elumalai G, Razli AI. The effect of aquatic exercise program on low-back pain disability in obese women. J Exerc Rehabil 2019;15(6):855-860. PubMed
Chen Y, Xu S, Shen J, et al. Effect of exercise on fatigue in multiple sclerosis patients: A network meta-analysis. Int J Sports Med 2021;42(14):1250-1259. PubMed
Carvalho RGS, Silva MF, Dias JM, et al. Effectiveness of additional deep-water running for disability, lumbar pain intensity, and functional capacity in patients with chronic low back pain: A randomised controlled trial with 3-month follow-up. Musculoskel
Chen LJ, Fox KR, Ku PW, Chang YW. Effects of aquatic exercise on sleep in older adults with mild sleep impairment: a randomized controlled trial. Int J Behav Med. 2016;23(4):501-6. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Practicing Aquatic Exercise While Taking Pregabalin: Common Questions

Is it safe to practice Aquatic Exercise while taking Pregabalin?

We do not list a known interaction between Aquatic Exercise and Pregabalin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Aquatic Exercise and Pregabalin have any of the same side effects?

Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Aquatic Exercise and Pregabalin used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Aquatic Exercise in each. That is a conversation for your prescriber, especially if Pregabalin is being adjusted to a target.

Does Pregabalin interact with any supplements?

Yes. Pregabalin has documented interactions with 95 supplements in our database — Aquatic Exercise is not one of them. The Pregabalin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Aquatic Exercise monograph Uses, safety profile, and every drug interaction in one place Pregabalin drug information The full plain-English guide to this medication Pregabalin supplement interactions Every supplement checked against Pregabalin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 49 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pregabalin and Aquatic Exercise?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.