Drug & supplement interaction

Asafoetida + Inotersen

Inotersen brand name: Tegsedi.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Asafoetida has a moderate interaction with Inotersen. Theoretically, asafoetida might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Asafoetida and Inotersen

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Inotersen

Inotersen falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Asafoetida interacts with.

Theoretically, asafoetida might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs. Some anticoagulant/antiplatelet drugs include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Inotersen (Tegsedi) is a medicine for hereditary transthyretin amyloidosis, and one of its known effects is that it can lower your platelet count. Platelets are the tiny cells that help your blood clot, so people on this drug already need regular blood monitoring to watch for bleeding or bruising.

Asafoetida contains natural coumarin compounds that may have a mild blood-thinning effect. On its own this is only a theoretical concern, based on the plant's chemistry rather than real patient studies. But because Inotersen can already drop your platelets, stacking a supplement that might thin the blood could in theory add up to easier bruising, nosebleeds, or bleeding gums. The pinch used in cooking is very unlikely to matter; concentrated capsules are the real question. Please check with your pharmacist or doctor before using them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Asafoetida Also Interacts With Other Medications

Asafoetida has 288 moderate known drug interactions in our database — the Inotersen one above is one of them. If you take anything else, check it against the full list below.

Moderate 288 No known interaction 2,542 (incl. Inotersen)
Taking anything else?

Check Another of Your Medications Against Asafoetida

Covers the 2,830 medications we’ve checked against Asafoetida. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Inotersen

This page covers Asafoetida only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Inotersen page lists 208 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Asarabacca (major), Danshen (major), Piracetam (major), Siberian Cocklebur (major) and Aconite (moderate).

By severity: 4 major · 186 moderate · 18 minor.

From our pharmacist’s overview on the Inotersen page

“Danshen is the entry I would flag first for anyone taking inotersen (Tegsedi). Inotersen can drive platelet counts dangerously low, and 202 of the 208 supplements on this page add some blood-thinning or antiplatelet effect on top of that.”

Reviewed by 2 · Jul 18, 2026

Open the Inotersen interaction page

One more smart check

Taking Asafoetida as Part of a Dietary Supplement Product? Check It for Interactions

We hold 40 real supplement products containing Asafoetida, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Asafoetida. Your product may carry other ingredients that interact with Inotersen too, on top of Asafoetida — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Asafoetida and Inotersen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Asafoetida
Top half

#626 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Inotersen
Steady interest

#2,435 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Asafoetida

What is Asafoetida?

Asafoetida
  • Digestive upset and gas
  • Bloating and stomach cramps
  • Irritable bowel symptoms
  • Respiratory complaints
  • Used as a cooking spice

Asafoetida is a strong-smelling plant resin used widely as a spice and in traditional medicine, mainly for digestive complaints. Solid human evidence for its medicinal benefits is limited, though it is generally considered safe in the small amounts used in cooking. Talk with your pharmacist or doctor before using concentrated supplements, and avoid them during pregnancy and breastfeeding.

Read the full Asafoetida monograph & all interactions
Keep checking

Other Drugs & Asafoetida

Browse every other medication we’ve checked against Asafoetida — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
288Moderate
0Minor
2,541No known interaction
288 Moderate 2,541 No interaction
Moderate

288 interactions

Showing 60 of 288 moderate interactions — see all 288 on the Asafoetida page.

No interaction 2,541 drugs checked — show the list

We also checked Asafoetida against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,541 medications checked with no known interaction — see the full Asafoetida list.

See the full Asafoetida interactions page
See every supplement checked against Inotersen, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Asafoetida monograph › Uses, safety, and every drug interaction in one place Inotersen supplement interactions › Every supplement checked against Inotersen, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Asafoetida and Inotersen Together: Common Questions

Can you take Asafoetida with Inotersen?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Asafoetida and Inotersen interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Inotersen and Asafoetida?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.