Medication interaction hub

What Supplements Interact with Inotersen?

Inotersen brand name: Tegsedi. Every interaction below applies to the brands too.

208 Interactions 4 Major 186 Moderate 18 Minor
Curated & coded by · Clinical Pharmacist · Updated October 6, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Inotersen? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Inotersen against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Danshen is the entry I would flag first for anyone taking inotersen (Tegsedi). Inotersen can drive platelet counts dangerously low, and 202 of the 208 supplements on this page add some blood-thinning or antiplatelet effect on top of that. That overlap is why this list deserves genuine care, not a quick skim. Most entries rate moderate, 186 of them, plus 18 minor, but they push on the drug's own biggest safety problem, so even a mild antiplatelet herb like willow bark carries more weight here than it would with most medicines.

The second theme is kidney strain. Inotersen requires regular kidney monitoring because it can inflame the kidneys, and six ingredients can harm the kidneys on their own, led by Siberian cocklebur, whose major rating rests on well-documented evidence. Four entries in all rate major, split between the bleeding and kidney risks, and those four are the ones to understand before anything else below.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 186 Minor 18 No known interaction 1,244

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Inotersen: Top Interactions at a Glance

The Inotersen supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 208 interacting ingredients — plus 1,244 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Inotersen Combinations Today

The Inotersen + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Vitamin E + Inoterseni

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.

Read the full interaction Moderate Likelihood Unlikely Arnica + Inoterseni

Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible European Barberry + Inoterseni

Theoretically, European barberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Bishop's Weed + Inoterseni

Bergapten, a constituent of bishop's weed, has antiplatelet activity.

Read the full interaction Moderate Likelihood Possible Vinpocetine + Inoterseni

Vinpocetine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Sweet Vernal Grass + Inoterseni

Hay prepared from dried sweet vernal grass contains an anticoagulant, dicoumarol, which has been associated with fatal hemorrhages in animals.

Read the full interaction
The complete list

Every Supplement Checked Against Inotersen

All 1,452 ingredients in our database, ranked by severity — 208 with a Inotersen interaction on file and 1,244 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Inotersen?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin E with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.

Full Vitamin E + Inotersen answer

Can you take Arnica with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Full Arnica + Inotersen answer

Can you take European Barberry with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European barberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full European Barberry + Inotersen answer

Can you take Bishop's Weed with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has antiplatelet activity.

Full Bishop's Weed + Inotersen answer

Can you take Vinpocetine with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Vinpocetine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Vinpocetine + Inotersen answer

Can you take Lion's Mane Mushroom with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Full Lion's Mane Mushroom + Inotersen answer

Can you take Lotus with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of lotus with other antiplatelet drugs might reduce platelet aggregation and increase the risk of bleeding.

Full Lotus + Inotersen answer

Can you take Lycopene with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Full Lycopene + Inotersen answer

Can you take Magnolia with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.

Full Magnolia + Inotersen answer

Can you take Mangosteen with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.

Full Mangosteen + Inotersen answer

Can you take Maral Root with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that maral root tincture can reduce platelet aggregation.

Full Maral Root + Inotersen answer

Can you take Maritime Pine with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Full Maritime Pine + Inotersen answer

Can you take Marjoram with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that marjoram extract inhibits platelet aggregation and adhesion.

Full Marjoram + Inotersen answer

Can you take Melatonin with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet dru...

Full Melatonin + Inotersen answer

Can you take Mesoglycan with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combined use might increase bleeding risk.

Full Mesoglycan + Inotersen answer

Can you take Methoxylated Flavones with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that some methoxylated flavones have antiplatelet effects.

Full Methoxylated Flavones + Inotersen answer

Can you take Mountain Ash with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.

Full Mountain Ash + Inotersen answer

Can you take N-acetyl Cysteine (nac) with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full N-acetyl Cysteine (nac) + Inotersen answer

Can you take Nattokinase with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Full Nattokinase + Inotersen answer

Can you take Niacin with Inotersen?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Full Niacin + Inotersen answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Inotersen is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Inotersen, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Inotersen sits in 2 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Inotersen through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Inotersen through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Inotersen

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Inotersen.

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Pharmacist Counseling Corner

Inotersen & Supplements: Common Questions

What supplements interact with Inotersen?
Our database currently documents 208 ingredients with a known Inotersen interaction (4 major, 186 moderate, 18 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 208. The highest-ranked right now: Siberian Cocklebur, Danshen, Piracetam.
Which Inotersen supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Danshen, Piracetam and Asarabacca. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Inotersen?
Plenty of supplements coexist fine with Inotersen; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Tegsedi have the same supplement interactions as Inotersen?
Yes — Tegsedi all contain Inotersen, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Inotersen and my other medications?
This page covers Inotersen against supplements and herbal ingredients. Checking Inotersen against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 6, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.