Autumn Crocus + Tipiracil Hydrochloride, Trifluridine
Tipiracil Hydrochloride, Trifluridine brand name: Lonsurf.
We found no known interaction between Autumn Crocus and Tipiracil Hydrochloride, Trifluridine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tipiracil Hydrochloride, Trifluridine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Autumn Crocus and Tipiracil Hydrochloride, Trifluridine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Tipiracil Hydrochloride, Trifluridine and Autumn Crocus in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Autumn Crocus safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Tipiracil Hydrochloride, Trifluridine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Tipiracil Hydrochloride, Trifluridine is filed under a single classification — oral drugs. Autumn Crocus has documented interactions with 1 drug class — the most serious being colchicine (major) — and none of Tipiracil Hydrochloride, Trifluridine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Autumn Crocus Does Interact With Other Medications
Autumn Crocus has 2 major, known drug interactions in our database — Tipiracil Hydrochloride, Trifluridine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Autumn Crocus
We haven’t checked that one against Autumn Crocus yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Autumn Crocus. Pick one to open its full report.
Autumn Crocus in Pregnancy & Breastfeeding
When used orally. Autumn crocus is a potential mutagen and is associated with significant and potentially fatal adverse effects; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Tipiracil Hydrochloride, Trifluridine Products Have a Food Rule — Autumn Crocus Should Not Break It
At least one FDA label for a product containing Tipiracil Hydrochloride, Trifluridine says to take it with food. If you take Autumn Crocus on an empty stomach out of habit, keep them separate — and take Tipiracil Hydrochloride, Trifluridine with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tipiracil Hydrochloride, Trifluridine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION Recommended Dosage : 35 mg/m 2 /dose orally twice daily with food on Days 1 through 5 and Days 8 through 12 of each 28-day cycle.
From the Dosage and Administration section of the FDA label we read for Tipiracil Hydrochloride, Trifluridine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Tipiracil Hydrochloride, Trifluridine
This page covers Autumn Crocus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tipiracil Hydrochloride, Trifluridine page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
Open the Tipiracil Hydrochloride, Trifluridine interaction page
Taking Autumn Crocus as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1 real supplement products containing Autumn Crocus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Autumn Crocus. Even though Autumn Crocus itself has no known interaction with Tipiracil Hydrochloride, Trifluridine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Autumn Crocus and Tipiracil Hydrochloride, Trifluridine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,335 of 1,452 supplements looked up here in the last 7 days
#633 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Autumn Crocus reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Autumn Crocus and Tipiracil Hydrochloride, Trifluridine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Autumn Crocus
What is Autumn Crocus?
- Gout
- Familial Mediterranean fever
- Joint pain and inflammation
- Rheumatoid arthritis (traditional use)
Autumn Crocus is a highly poisonous plant that contains colchicine, a compound that has real medical value but is dangerous in its raw form. You should never eat the plant or take homemade preparations from it. If you need colchicine for gout or familial Mediterranean fever, use the standardized, FDA-approved prescription product under a doctor's supervision.
Colchicum autumnale · Colchicaceae · Corm (bulb-like underground stem), seeds, and flowers · Rarely used as a raw plant or crude extract; the purified active compound (colchicine) is available only as an FDA-approved prescription medicine
An interaction check asks whether these two react with each other — it does not ask whether Autumn Crocus is a good idea for someone in your situation. Here is what our Autumn Crocus record says about it on its own.
Autumn Crocus: dosing
There is no safe established dose of the Autumn Crocus plant as a supplement, and it should not be taken in any homemade form. The colchicine content of the plant cannot be reliably measured, so even small amounts can cause serious harm.The only appropriate way to use colchicine is through an FDA-approved prescription product, which has a precise, controlled dose set by your healthcare provider.
From our Autumn Crocus monograph — the full record covers uses, side effects and every documented interaction.
About Trifluridine and Tipiracil
What Is Trifluridine and Tipiracil Used For?
Brand name: Lonsurf
Lonsurf (trifluridine and tipiracil) is used to treat adults with metastatic colorectal cancer — either alone or combined with bevacizumab — after prior treatment with several other chemotherapy regimens and targeted therapies.
Lonsurf is also used for adults with metastatic gastric or gastroesophageal junction adenocarcinoma (cancer of the stomach or where the stomach meets the esophagus) who have already received at least two prior chemotherapy regimens.
Other Drugs & Autumn Crocus
Browse every other medication we’ve checked against Autumn Crocus — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
2 interactions
No interaction 2,827 drugs checked — show the list
We also checked Autumn Crocus against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Metoprolol ›
- Ivermectin ›
- Aspirin ›
- Acetaminophen ›
- Rivaroxaban ›
- Rosuvastatin ›
- Abemaciclib ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Hydroxyurea ›
- Methamphetamine ›
- Valacyclovir ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Amitriptyline ›
- Bupropion ›
- Methotrexate ›
- Isotretinoin ›
- Bendamustine ›
- Amphetamine ›
- Amlodipine Besylate ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Pregabalin ›
- Azithromycin ›
- Lamotrigine ›
- Gabapentin ›
- Dextroamphetamine ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Letrozole ›
- Naproxen ›
- Duloxetine ›
- Citalopram ›
- Buspirone ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Autumn Crocus list.
Autumn Crocus References
The 9 references that drive our Autumn Crocus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Brvar, M., Kozelj, G., Mozina, M., and Bunc, M. Acute poisoning with autumn crocus (Colchicum autumnale L.). Wien.Klin Wochenschr. 3-31-2004;116(5-6):205-208. PubMed
- Kritikos A, Spertini O. Reversible granulocyte abnormalities after accidental ingestion of Colchicum autumnale. Blood 2017;130(1):95. doi: 10.1182/blood-2017-02-766410. PubMed
- Nagesh KR, Menezes RG, Rastogi P, et al. Suicidal plant poisoning with Colchicum autumnale. J Forensic Leg Med 2011;18(6):285-7. doi: 10.1016/j.jflm.2011.04.008. PubMed
- Brncic N, Viskovic I, Peric R, et al. Accidental plant poisoning with Colchicum autumnale: report of two cases. Croat Med J 2001;42(6):673-5.
- Sundov Z, Nincevic Z, Definis-Gojanovic M, et al. Fatal colchicine poisoning by accidental ingestion of meadow saffron-case report. Forensic Sci Int 2005;149(2-3):253-6. PubMed
- Boisramé-Helms J, Rahmani H, Stiel L, Tournoud C, Sauder P. Extracorporeal life support in the treatment of colchicine poisoning. Clin Toxicol (Phila) 2015;53(8):827-9.
- Razinger G, Kozelj G, Gorjup V, Grenc D, Brvar M. Accidental poisoning with autumn crocus (Colchicum autumnale): a case series. Clin Toxicol (Phila). 2021 Jun;59(6):493-9.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Autumn Crocus and Tipiracil Hydrochloride, Trifluridine Together: Common Questions
Is it safe to take Autumn Crocus with Tipiracil Hydrochloride, Trifluridine?
Do Autumn Crocus and Tipiracil Hydrochloride, Trifluridine have any of the same side effects?
Should I take Autumn Crocus and Tipiracil Hydrochloride, Trifluridine at the same time of day?
How was the Autumn Crocus and Tipiracil Hydrochloride, Trifluridine combination checked?
Does Autumn Crocus interact with any other medications?
Does Tipiracil Hydrochloride, Trifluridine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.