Benzoin + Mexiletine
Mexiletine brand name: Mexitil.
We found no known interaction between Benzoin and Mexiletine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Mexiletine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Benzoin and Mexiletine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Mexiletine and Benzoin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Benzoin at all — not against Mexiletine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Benzoin safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Mexiletine Products Have a Food Rule — Benzoin Should Not Break It
At least one FDA label for a product containing Mexiletine says to take it with food. If you take Benzoin on an empty stomach out of habit, keep them separate — and take Mexiletine with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Mexiletine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Administration with food or antacid is recommended.
From the Dosage and Administration section of the FDA label we read for Mexiletine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Mexiletine
This page covers Benzoin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mexiletine page lists 152 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), 1,3-dmaa (moderate), Acacia Rigidula (moderate), Active Hexose Correlated Compound (ahcc) (moderate) and Adrafinil (moderate).
By severity: 1 major · 107 moderate · 44 minor.
From our pharmacist’s overview on the Mexiletine page
“Mexiletine (Mexitil) steadies the heart's rhythm, and its benefit depends on holding a fairly precise blood level, so the 152 supplements on this list deserve real attention rather than a shrug. Only one entry, activated charcoal, is rated major, because it can soak up the drug in the gut and cut how much actually reaches your bloodstr…”
Reviewed by 2 · Jul 18, 2026
Taking Benzoin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 15 real supplement products containing Benzoin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Benzoin. Even though Benzoin itself has no known interaction with Mexiletine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Benzoin and Mexiletine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,316 of 1,452 supplements looked up here in the last 7 days
#727 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Benzoin reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Benzoin and Mexiletine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Benzoin
What is Benzoin?
- Skin protectant for cuts and cracked skin
- Helping bandages and dressings stick to skin
- Steam inhalation for cough and congestion
- Throat and mouth soothing washes
- Fragrance and incense
- Mild antiseptic for minor wounds
Benzoin is a fragrant resin from Southeast Asian Styrax trees, used mainly on the skin as a protectant and as 'compound benzoin tincture' to help dressings stick. Evidence for internal or medicinal benefits is limited, and it can cause skin irritation or allergic reactions, so it is best used topically as directed. Pregnant or breastfeeding people and anyone considering it should check with a pharmacist or doctor first.
Styrax benzoin · Styracaceae · Resin (balsamic gum) from the tree bark · Tincture (compound benzoin tincture), topical resin, inhalation/steam, incense, essential oil
An interaction check asks whether these two react with each other — it does not ask whether Benzoin is a good idea for someone in your situation. Here is what our Benzoin record says about it on its own.
Benzoin: dosing
There is no standardized medicinal dose of benzoin, and amounts vary widely by product and use. For skin and adhesive uses, follow the directions on the product label or the instructions from your healthcare provider.For steam inhalation or aromatherapy, manufacturers usually give a recommended amount to add to hot water or a diffuser.
From our Benzoin monograph — the full record covers uses, side effects and every documented interaction.
About Mexiletine
What Is Mexiletine Used For?
Brand name: Mexitil
Mexiletine Hydrochloride capsules are indicated for the treatment of documented, life-threatening ventricular arrhythmias — for example, sustained ventricular tachycardia (a dangerously fast heart rhythm originating in the lower chambers). Because mexiletine itself can trigger arrhythmias, it is not recommended for minor or symptom-free irregular heartbeats.
Treatment is started in a hospital setting so heart rhythm can be monitored closely. Antiarrhythmic drugs, including mexiletine, have not been shown to improve overall survival in patients with ventricular arrhythmias.
Other Drugs & Benzoin
Browse every other medication we’ve checked against Benzoin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Benzoin against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Warfarin Sodium ›
- Tirzepatide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Acyclovir ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Fluoxetine ›
- Lamotrigine ›
- Acetaminophen, Codeine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Dextroamphetamine ›
- Azithromycin ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Quetiapine ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Benzoin list.
Benzoin References
The 4 references that drive our Benzoin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
- Parmar RC, Patel DM, Patel MV, et al. Medicated adhesive dressing is a safe and non-inferior cutaneous seal as compared to compound tincture benzoin dermal seal for percutaneous interventions. J Family Med Prim Care. 2019;8(7):2384-8. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Benzoin and Mexiletine Together: Common Questions
Is it safe to take Benzoin with Mexiletine?
Do Benzoin and Mexiletine have any of the same side effects?
Should I take Benzoin and Mexiletine at the same time of day?
Does Mexiletine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.