Drug & supplement interaction

Beta-cryptoxanthin + Crisaborole

Crisaborole brand name: Eucrisa.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Beta-cryptoxanthin and Crisaborole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Beta-cryptoxanthin and Crisaborole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Crisaborole and Beta-cryptoxanthin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Beta-cryptoxanthin at all — not against Crisaborole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Beta-cryptoxanthin safety at a glance

Beta-cryptoxanthin overall Use caution Considered safe in normal food amounts, but the safety of high-dose supplements is not well studied.
Pregnancy Likely Safe When used orally and appropriately in amounts found in foods. There is insufficient reliable information available about the safety of supplemental beta-cryptox... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally and appropriately in amounts found in foods. There is insufficient reliable information available about the safety of supplemental beta-cryptox... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Crisaborole and Beta-cryptoxanthin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Crisaborole’s Own FDA Label Lists

This is not an interaction — none of it involves Beta-cryptoxanthin. These are the most notable effects listed in the ADVERSE REACTIONS section of Crisaborole’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both.

  • A skin rash mentioned in 6.5% of FDA reports for Crisaborole

From the ADVERSE REACTIONS section of the FDA label for Crisaborole. Read the label on DailyMed › Where a percentage is shown, it is the share of 9,540 voluntary FDA FAERS reports for Crisaborole that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Beta-cryptoxanthin’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Beta-cryptoxanthin side to compare — that is a limit of the record, not a statement that Beta-cryptoxanthin has no side effects.

Special populations

Beta-cryptoxanthin in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally and appropriately in amounts found in foods. There is insufficient reliable information available about the safety of supplemental beta-cryptoxanthin; avoid use.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Crisaborole

This page covers Beta-cryptoxanthin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Crisaborole page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Crisaborole page

“Crisaborole (Eucrisa) is an ointment for eczema, and its supplement interaction list is short: three ingredients, none rated major. All three matter for the same reason.”

Reviewed by 2 · Jul 18, 2026

Open the Crisaborole interaction page

How much people look this up

Where Beta-cryptoxanthin and Crisaborole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beta-cryptoxanthin
Steady interest

#1,290 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Crisaborole
Top half

#1,333 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Beta-cryptoxanthin is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Beta-cryptoxanthin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Beta-cryptoxanthin and Crisaborole records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Beta-cryptoxanthin

What is Beta-cryptoxanthin?

  • Antioxidant support
  • Eye health
  • Bone health
  • Vitamin A source
  • General wellness

Beta-cryptoxanthin is a natural orange-red plant pigment (a carotenoid) found in fruits like oranges, tangerines, and papaya, and it can be turned into vitamin A in the body. Diets rich in beta-cryptoxanthin are linked in some studies to better bone and lung health, but the evidence for supplements is limited. For most people, getting it from colorful fruits and vegetables is the safest and best-studied approach.

Naturally found in fruits and vegetables; also made as a supplement · Capsules, softgels, and multivitamin/carotenoid blends; naturally present in whole foods

An interaction check asks whether these two react with each other — it does not ask whether Beta-cryptoxanthin is a good idea for someone in your situation. Here is what our Beta-cryptoxanthin record says about it on its own.

Beta-cryptoxanthin: dosing

There is no established standard supplement dose for beta-cryptoxanthin. Most research reflects amounts obtained through a normal diet rich in fruits and vegetables rather than from pills.If you choose to take a supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Beta-cryptoxanthin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Beta-cryptoxanthin monograph & all interactions
Medication

About Crisaborole Topical

What Is Crisaborole Topical Used For?

Brand name: Eucrisa

Eucrisa (crisaborole) ointment is used on the skin to treat mild to moderate atopic dermatitis — commonly known as eczema — in adults and in children as young as 3 months old.

Most-Reported Side Effects for Crisaborole

From FAERS, the FDA’s public side-effect reporting system (9,540 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Application site pain 1,416 reports
Burning sensation 985 reports
Pruritus 643 reports
Rash 616 reports
Eczema 459 reports
See full Crisaborole Topical drug information
Keep checking

Other Drugs & Beta-cryptoxanthin

Browse every other medication we’ve checked against Beta-cryptoxanthin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Beta-cryptoxanthin References

The 2 sources that drive our Beta-cryptoxanthin monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Beta-cryptoxanthin is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Vitamin A and Carotenoids - Health Professional Fact Sheet — NIH Office of Dietary Supplements Source
  2. Vitamin A — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Beta-cryptoxanthin and Crisaborole Together: Common Questions

Is it safe to take Beta-cryptoxanthin with Crisaborole?
We do not list a known interaction between Beta-cryptoxanthin and Crisaborole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Crisaborole interact with any supplements?
Yes. Crisaborole has documented interactions with 3 supplements in our database — Beta-cryptoxanthin is not one of them. The Crisaborole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Crisaborole and Beta-cryptoxanthin?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.