Drug & supplement interaction

Black Bryony + Doxepin

Doxepin brand names: Sinequan, Doxepin, Zonalon.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Black Bryony and Doxepin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Black Bryony and Doxepin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Doxepin and Black Bryony in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Black Bryony at all — not against Doxepin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Bryony safety at a glance

Black Bryony overall Avoid The plant contains irritant and toxic compounds and can cause poisoning, so it is generally best avoided.
Pregnancy Unsafe When used orally. All parts of the black bryony plant are considered poisonous. Read the full pregnancy detail
Breastfeeding Unsafe When used orally. All parts of the black bryony plant are considered poisonous. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Doxepin and Black Bryony? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Black Bryony Itself Has Been Linked To

This is not an interaction — nothing below involves Doxepin. It is the side-effect record for Black Bryony on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Black Bryony, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on Additional detail

    “Orally, all parts of the black bryony plant are considered poisonous due to its saponin content. Black bryony has been reported to cause severe gastrointestinal irritation, vomiting, diarrhea, seizures, respiratory failure, and kidney failure (18). Topically, black bryony has been reported to cause contact dermatitis.”

    Black Bryony · Natural Medicines adverse-effect record, reported in dermatitis.

    4 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 3829. Schmidt RJ, Moult SP. The dermatitic properties of black bryony (Tamus communis L.). Contact Dermatitis 1983;9:390-6.
    3. 35781. Kashchenko, V. B. and Kozhukhar', G. S. [Toxidermia caused by Tamus communis]. Vestn.Dermatol.Venerol. 1986;(5):50-51.
    4. 35782. Miliavskii, A. I. [Contact dermatitis caused by black bryony]. Vestn.Dermatol.Venerol. 1979;(7):49-50.

    “Orally, black bryony has been reported to cause seizures (18).”

    Black Bryony · Natural Medicines adverse-effect record, reported in epilepsy.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Kidney problems Worth acting on Additional detail

    “Orally, black bryony has been reported to cause renal failure (18).”

    Black Bryony · Natural Medicines adverse-effect record, reported in kidney failure.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Swelling Additional detail

    “Topically, black bryony has been reported to cause contact dermatitis involving skin irritation, rash, swelling, pustules, and wheals (18,3829,35781,35782). The histamine and calcium oxalate crystal constituents of black bryony mucilage are thought to contribute to these dermatologic reactions.”

    Black Bryony · Natural Medicines adverse-effect record, reported in dermatitis.

    4 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 3829. Schmidt RJ, Moult SP. The dermatitic properties of black bryony (Tamus communis L.). Contact Dermatitis 1983;9:390-6.
    3. 35781. Kashchenko, V. B. and Kozhukhar', G. S. [Toxidermia caused by Tamus communis]. Vestn.Dermatol.Venerol. 1986;(5):50-51.
    4. 35782. Miliavskii, A. I. [Contact dermatitis caused by black bryony]. Vestn.Dermatol.Venerol. 1979;(7):49-50.
  • Diarrhea / Vomiting Additional detail

    “Orally, black bryony has been reported to cause severe mouth, pharyngeal, and gastrointestinal irritation. It has also been reported to cause vomiting and diarrhea (18).”

    Black Bryony · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • A skin rash Additional detail

    Recorded for Black Bryony in the same Natural Medicines adverse-effect record shown under Seizures above.

Everything above comes from the Natural Medicines adverse-effect record for Black Bryony — expand a row for the licensed statement it rests on. We haven’t matched Doxepin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Doxepin.

Special populations

Black Bryony in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally. All parts of the black bryony plant are considered poisonous.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Doxepin

This page covers Black Bryony only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Doxepin page lists 186 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), Arsenic (major) and Beer (major).

By severity: 15 major · 145 moderate · 26 minor.

From our pharmacist’s overview on the Doxepin page

“Doxepin is a sedating tricyclic prescribed for depression, anxiety, and often sleep itself, and the people taking it tend to shop the same shelf where the trouble sits. Of the 186 supplements on file, 78 deepen its drowsiness, with alcohol (beer and wine carry major, well-documented ratings) and kava the clearest examples, and I would…”

Reviewed by 2 · Jul 18, 2026

Open the Doxepin interaction page

How much people look this up

Where Black Bryony and Doxepin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Bryony
Steady interest

#1,261 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Doxepin
Top half

#1,249 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Bryony reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Black Bryony and Doxepin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Black Bryony

What is Black Bryony?

Black Bryony
  • Bruises and sprains (applied to the skin)
  • Joint and muscle pain
  • Chilblains
  • Rheumatic complaints
  • Skin and folk "healing" remedies

Black Bryony is a toxic climbing plant whose root has been used in folk medicine, mostly applied to the skin for bruises and aches. There is little to no reliable scientific evidence that it works, and it can cause serious poisoning if swallowed or severe irritation on the skin. Because of these real risks, it is best avoided, especially without guidance from a healthcare professional.

Dioscorea communis · Dioscoreaceae · Root (tuber); occasionally berries and aerial parts (all considered toxic) · Traditional poultices and ointments for external use; rarely sold as a modern supplement

An interaction check asks whether these two react with each other — it does not ask whether Black Bryony is a good idea for someone in your situation. Here is what our Black Bryony record says about it on its own.

Black Bryony: dosing

There is no established safe dose for Black Bryony. It has not been studied well enough to recommend any amount, and because it is toxic, no standard dose exists for taking it by mouth.If you ever encounter a product that contains it, do not assume it is safe. Given the risks, the safest approach is not to use it at all.

From our Black Bryony monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Bryony monograph & all interactions
Medication

About Doxepin (Insomnia)

What Is Doxepin (Insomnia) Used For?

Brand names: Sinequan, Doxepin, Zonalon

This product is marketed to temporarily relieve occasional trouble sleeping when it's brought on by anxiety, restlessness, stress, or sensitivity to caffeine.

It is a homeopathic remedy — meaning its claims are based on traditional homeopathic practice, not accepted medical evidence, and it has not been evaluated by the FDA for effectiveness.

Most-Reported Side Effects for Doxepin

From FAERS, the FDA’s public side-effect reporting system (12,553 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Toxicity to various agents 988 reports
Completed suicide 828 reports
Fatigue 793 reports
Nausea 679 reports
Headache 642 reports
See full Doxepin (Insomnia) drug information
Keep checking

Other Drugs & Black Bryony

Browse every other medication we’ve checked against Black Bryony — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Black Bryony against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Black Bryony list.

See the full Black Bryony interactions page
See every supplement checked against Doxepin, ranked by severity
Evidence & sources

Black Bryony References

The 4 references that drive our Black Bryony monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Schmidt RJ, Moult SP. The dermatitic properties of black bryony (Tamus communis L.). Contact Dermatitis 1983;9:390-6.
  3. Kashchenko, V. B. and Kozhukhar', G. S. [Toxidermia caused by Tamus communis]. Vestn.Dermatol.Venerol. 1986;(5):50-51.
  4. Miliavskii, A. I. [Contact dermatitis caused by black bryony]. Vestn.Dermatol.Venerol. 1979;(7):49-50.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Bryony and Doxepin Together: Common Questions

Is it safe to take Black Bryony with Doxepin?
We do not list a known interaction between Black Bryony and Doxepin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Doxepin interact with any supplements?
Yes. Doxepin has documented interactions with 186 supplements in our database — Black Bryony is not one of them. The Doxepin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Bryony monograph Uses, safety profile, and every drug interaction in one place Doxepin (Insomnia) drug information The full plain-English guide to this medication Doxepin supplement interactions Every supplement checked against Doxepin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Doxepin and Black Bryony?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.