Drug & supplement interaction

Black Raspberry + Esketamine

Esketamine brand name: Spravato.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Black Raspberry and Esketamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Black Raspberry and Esketamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Esketamine and Black Raspberry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Black Raspberry at all — not against Esketamine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Raspberry safety at a glance

Black Raspberry overall Generally safe Generally safe when eaten as a food; concentrated supplements are less well studied.
Pregnancy Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of black raspberry in medicinal amoun... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of black raspberry in medicinal amoun... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Esketamine and Black Raspberry? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Esketamine’s Own FDA Label Lists

This is not an interaction — none of it involves Black Raspberry. These are the most notable effects listed in the ADVERSE REACTIONS section of Esketamine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 4 of them are worth acting on rather than waiting out — marked below.

  • Thoughts of self-harm Worth acting on mentioned in 7.6% of FDA reports for Esketamine
  • Memory problems Worth acting on
  • Low mood Worth acting on mentioned in 4.9% of FDA reports for Esketamine
  • Raised blood pressure Worth acting on mentioned in 4.8% of FDA reports for Esketamine
  • Drowsiness mentioned in 15.3% of FDA reports for Esketamine
  • Anxiety or restlessness
  • Tiredness
  • Dizziness
  • Nausea mentioned in 5.4% of FDA reports for Esketamine
  • Vomiting

Showing the 10 most notable of 11 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Esketamine. Read the label on DailyMed › Where a percentage is shown, it is the share of 17,728 voluntary FDA FAERS reports for Esketamine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Black Raspberry’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Black Raspberry side to compare — that is a limit of the record, not a statement that Black Raspberry has no side effects.

Special populations

Black Raspberry in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of black raspberry in medicinal amounts during pregnancy or breast-feeding; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Esketamine

This page covers Black Raspberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Esketamine page lists 11 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Scopolia (major), Cowhage (moderate), Dhea (moderate), Griffonia Simplicifolia (moderate) and Indian Snakeroot (moderate).

By severity: 1 major · 6 moderate · 4 minor.

From our pharmacist’s overview on the Esketamine page

“Esketamine (Spravato) is the nasal spray for depression that hasn't responded to standard treatment, and its supplement list deserves genuine respect. Scopolia carries the only major rating and is the entry to understand before any other; pairing it with the medication can raise the risk of anticholinergic effects, meaning dry mouth, b…”

Reviewed by 2 · Jul 18, 2026

Open the Esketamine interaction page

One more smart check

Taking Black Raspberry as Part of a Dietary Supplement Product? Check It for Interactions

We hold 183 real supplement products containing Black Raspberry, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Black Raspberry. Even though Black Raspberry itself has no known interaction with Esketamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Black Raspberry and Esketamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Raspberry
Top half

#604 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Esketamine
Steady interest

#1,864 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Raspberry reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Black Raspberry and Esketamine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Black Raspberry

What is Black Raspberry?

Black Raspberry
  • Antioxidant support
  • Heart health
  • Oral and gum health
  • Cancer prevention (under study)
  • Inflammation

Black raspberry is a nutrient-rich fruit packed with antioxidants like anthocyanins and ellagic acid, and as a food it is generally safe and healthy. Some early research explores it for cancer prevention, oral health, and heart health, but the evidence is preliminary and far from proven. Enjoy it as part of a balanced diet, and talk to your pharmacist or doctor before using concentrated supplements.

Rubus occidentalis · Rosaceae · Fruit (berries); sometimes leaves and seeds · Fresh or frozen berries, juice, powder, capsules, extracts, lozenges, gels

An interaction check asks whether these two react with each other — it does not ask whether Black Raspberry is a good idea for someone in your situation. Here is what our Black Raspberry record says about it on its own.

Black Raspberry: dosing

There is no official or standardized dose of black raspberry for any health condition. As a food, you can simply enjoy the fresh or frozen berries.For supplements, juices, and powders, the amount varies widely between products. The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Black Raspberry monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Raspberry monograph & all interactions
Medication

About Esketamine Nasal Spray

What Is Esketamine Nasal Spray Used For?

Brand name: Spravato

Spravato nasal spray is approved for two uses in adults. First, it treats treatment-resistant depression (TRD) — depression that has not responded to other antidepressants — either on its own or alongside an oral antidepressant. Second, it treats depressive symptoms in adults with major depressive disorder (MDD) who have acute suicidal ideation or behavior, always used together with an oral antidepressant in this case.

Important limits: Spravato has not been shown to prevent suicide or reduce suicidal thoughts or behavior on its own. It is not a replacement for hospitalization if that is clinically needed, and it is not approved as an anesthetic.

Most-Reported Side Effects for Esketamine

From FAERS, the FDA’s public side-effect reporting system (17,728 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dissociation 3,733 reports
Sedation 2,706 reports
Suicidal ideation 1,351 reports
Nausea 957 reports
Depression 873 reports
See full Esketamine Nasal Spray drug information
Keep checking

Other Drugs & Black Raspberry

Browse every other medication we’ve checked against Black Raspberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Black Raspberry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Black Raspberry list.

See the full Black Raspberry interactions page
See every supplement checked against Esketamine, ranked by severity
Evidence & sources

Black Raspberry References

The 4 references that drive our Black Raspberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. An JH, Kim DL, Lee TB, et al. Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes: A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial. Phytother Res. 2016;30(10):1634-40.
  2. Jeong HS, Hong SJ, Cho JY, et al. Effects of Rubus occidentalis extract on blood pressure in patients with prehypertension: Randomized, double-blinded, placebo-controlled clinical trial. Nutrition. 2016;32(4):461-7. PubMed
  3. Mallery SR, Tong M, Shumway BS, et al. Topical application of a mucoadhesive freeze-dried black raspberry gel induces clinical and histologic regression and reduces loss of heterozygosity events in premalignant oral intraepithelial lesions: results from a
  4. Jeong HS, Kim S, Hong SJ, et al. Black Raspberry Extract Increased Circulating Endothelial Progenitor Cells and Improved Arterial Stiffness in Patients with Metabolic Syndrome: A Randomized Controlled Trial. J Med Food. 2016;19(4):346-52. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Raspberry and Esketamine Together: Common Questions

Is it safe to take Black Raspberry with Esketamine?
We do not list a known interaction between Black Raspberry and Esketamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Esketamine interact with any supplements?
Yes. Esketamine has documented interactions with 11 supplements in our database — Black Raspberry is not one of them. The Esketamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Raspberry monograph Uses, safety profile, and every drug interaction in one place Esketamine Nasal Spray drug information The full plain-English guide to this medication Esketamine supplement interactions Every supplement checked against Esketamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Esketamine and Black Raspberry?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.