Medication interaction hub

What Supplements Interact with Esketamine?

Esketamine brand name: Spravato. Every interaction below applies to the brands too.

11 Interactions 1 Major 6 Moderate 4 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Esketamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Esketamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Esketamine (Spravato) is the nasal spray for depression that hasn't responded to standard treatment, and its supplement list deserves genuine respect. Scopolia carries the only major rating and is the entry to understand before any other; pairing it with the medication can raise the risk of anticholinergic effects, meaning dry mouth, blurred vision, confusion, and a racing heart. Most of the moderate entries push on the same brain chemistry the drug is already adjusting, including Griffonia simplicifolia, a source of 5-HTP that can add serotonergic side effects, including serotonin syndrome.

The gentlest end of the list includes everyday coffee and tea, whose tannins can bind the drug in lab studies, an effect never documented in people; spacing them well apart from a dose covers it. That makes 11 ingredients on file, six of them moderate and four minor, with scopolia alone demanding the closest attention.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 6 Minor 4 No known interaction 1,441

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Esketamine: Top Interactions at a Glance

The most significant Esketamine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 11 highest-ranked of 11 interacting ingredients — plus 1,441 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Esketamine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Scopolia + Esketaminei

Concomitant use of TCAs with scopolia can increase the risk for anticholinergic effects and adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Esketamine

All 1,452 ingredients in our database, ranked by severity — 11 with a Esketamine interaction on file and 1,441 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Esketamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Scopolia with Esketamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of TCAs with scopolia can increase the risk for anticholinergic effects and adverse effects.

Full Scopolia + Esketamine answer

Can you take Rauvolfia Vomitoria with Esketamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects of Rauvolfia vomitoria and increase the risk for adverse effects.

Full Rauvolfia Vomitoria + Esketamine answer

Can you take Cowhage with Esketamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.

Full Cowhage + Esketamine answer

Can you take Dhea with Esketamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the risk of psychiatric adverse events when used with antidepressants.

Full Dhea + Esketamine answer

Can you take Griffonia Simplicifolia with Esketamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Griffonia simplicifolia seed extract with antidepressant drugs might increase the risk of serotonergic adverse effects...

Full Griffonia Simplicifolia + Esketamine answer

Can you take Indian Snakeroot with Esketamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects of Indian snakeroot and increase the risk of adverse effects.

Full Indian Snakeroot + Esketamine answer

Can you take Yohimbe with Esketamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking yohimbe with TCAs can increase adverse effects.

Full Yohimbe + Esketamine answer

Can you take Black Tea with Esketamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, TCAs might bind with black tea constituents when taken at the same time.

Full Black Tea + Esketamine answer

Can you take Coffee with Esketamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, TCAs might bind with coffee constituents when taken at the same time.

Full Coffee + Esketamine answer

Can you take Pu-erh Tea with Esketamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, TCAs might bind with pu-erh tea constituents when taken at the same time.

Full Pu-erh Tea + Esketamine answer

Can you take Rhodiola with Esketamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.

Full Rhodiola + Esketamine answer

Can you take Scopolia with Esketamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of TCAs with scopolia can increase the risk for anticholinergic effects and adverse effects.

Full Scopolia + Esketamine answer

Can you take Rauvolfia Vomitoria with Esketamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects of Rauvolfia vomitoria and increase the risk for adverse effects.

Full Rauvolfia Vomitoria + Esketamine answer

Can you take Cowhage with Esketamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.

Full Cowhage + Esketamine answer

Can you take Dhea with Esketamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the risk of psychiatric adverse events when used with antidepressants.

Full Dhea + Esketamine answer

Can you take Griffonia Simplicifolia with Esketamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Griffonia simplicifolia seed extract with antidepressant drugs might increase the risk of serotonergic adverse effects...

Full Griffonia Simplicifolia + Esketamine answer

Can you take Indian Snakeroot with Esketamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects of Indian snakeroot and increase the risk of adverse effects.

Full Indian Snakeroot + Esketamine answer

Can you take Yohimbe with Esketamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking yohimbe with TCAs can increase adverse effects.

Full Yohimbe + Esketamine answer

Can you take Black Tea with Esketamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, TCAs might bind with black tea constituents when taken at the same time.

Full Black Tea + Esketamine answer

Can you take Coffee with Esketamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, TCAs might bind with coffee constituents when taken at the same time.

Full Coffee + Esketamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Esketamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Esketamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Esketamine sits in 2 interaction categories. Open any one to see what the group means:

Tricyclic Antidepressants (Tcas) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Esketamine through this category.

Antidepressant Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Esketamine through this category.

About Esketamine

Esketamine nasal spray (Spravato) is a prescription nasal spray used to treat treatment-resistant depression and depressive symptoms in adults with major depressive disorder who have acute suicidal thoughts or behaviors.

Generic name: Esketamine  ·  Brand name: Spravato.

See the full Esketamine Nasal Spray drug information

Related: does Esketamine deplete any nutrients?

Esketamine has 1 reported nutrient association in the research literature — see the Esketamine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Esketamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Esketamine.

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Pharmacist Counseling Corner

Esketamine & Supplements: Common Questions

What supplements interact with Esketamine?
In our interaction database, 11 supplement and herbal ingredients have an interaction with Esketamine on file — 1 rated major, 6 moderate, and 4 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Scopolia, Rauvolfia Vomitoria, Cowhage.
Which Esketamine supplement interactions are the most serious?
The 1 major-rated combination — led by Scopolia — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Esketamine?
That depends entirely on which supplement. The honest answer for Esketamine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Spravato have the same supplement interactions as Esketamine?
Yes — Spravato all contain Esketamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Esketamine deplete any vitamins or nutrients?
It might — Esketamine has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Esketamine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Esketamine and my other medications?
This page covers Esketamine against supplements and herbal ingredients. Checking Esketamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Esketamine Nasal Spray drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.