Drug & supplement interaction

Storax + Esketamine

Esketamine brand name: Spravato.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Storax and Esketamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Storax and Esketamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Esketamine and Storax in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Storax at all — not against Esketamine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Storax safety at a glance

Storax overall Use caution Generally used topically or as a flavoring in small amounts, but it can irritate skin and trigger allergic reactions.
Pregnancy Avoid There is not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoidance is the cautious choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Esketamine and Storax? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Storax Itself Has Been Linked To

This is not an interaction — nothing below involves Esketamine. It is the side-effect record for Storax on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Storax, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on Additional detail

    “When applied to large, open wounds, systemic absorption of storax can cause kidney damage (e.g., albuminuria and hemorrhagic nephritis) (18).”

    Storax · Natural Medicines adverse-effect record, reported in albuminuria.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • An allergic reaction Worth acting on Additional detail

    Recorded for Storax in the same Natural Medicines adverse-effect record shown under Kidney problems above.

  • Diarrhea Additional detail

    “Orally, storax can cause diarrhea (18).”

    Storax · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Storax — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Esketamine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Esketamine column appears here.

Everything else you take

See Every Supplement That Interacts With Esketamine

This page covers Storax only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Esketamine page lists 11 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Scopolia (major), Cowhage (moderate), Dhea (moderate), Griffonia Simplicifolia (moderate) and Indian Snakeroot (moderate).

By severity: 1 major · 6 moderate · 4 minor.

From our pharmacist’s overview on the Esketamine page

“Esketamine (Spravato) is the nasal spray for depression that hasn't responded to standard treatment, and its supplement list deserves genuine respect. Scopolia carries the only major rating and is the entry to understand before any other; pairing it with the medication can raise the risk of anticholinergic effects, meaning dry mouth, b…”

Reviewed by 2 · Jul 18, 2026

Open the Esketamine interaction page

One more smart check

Taking Storax as Part of a Dietary Supplement Product? Check It for Interactions

We hold 24 real supplement products containing Storax, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Storax. Even though Storax itself has no known interaction with Esketamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Storax and Esketamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Storax
Steady interest

#983 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Esketamine
Steady interest

#2,708 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Storax reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Storax and Esketamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Storax

What is Storax?

  • Skin wounds and scabies
  • Cough and respiratory complaints
  • As a topical antiseptic
  • Fragrance and incense
  • Flavoring agent

Storax is an aromatic balsam (resin) tapped from Liquidambar trees, used traditionally as a topical antiseptic, a remedy for skin parasites, and a respiratory aid. Modern human evidence for its health benefits is very limited, and it can cause skin irritation or allergic reactions, so use it cautiously and check with a pharmacist or doctor first.

Liquidambar orientalis · Altingiaceae · Balsam (resin) from the trunk bark · Balsam (resin), tincture, topical ointments and creams, incense, and an ingredient in compound preparations like Friar's Balsam

An interaction check asks whether these two react with each other — it does not ask whether Storax is a good idea for someone in your situation. Here is what our Storax record says about it on its own.

Storax: dosing

There is no well-established standardized dose for storax, and it has not been studied in the kind of rigorous trials needed to recommend specific amounts. It is most often used topically or as a small flavoring ingredient rather than as an oral supplement.If you use a product that contains storax, follow the directions on the label and do not exceed the recommended amount.

From our Storax monograph — the full record covers uses, side effects and every documented interaction.

Read the full Storax monograph & all interactions
Medication

About Esketamine Nasal Spray

What Is Esketamine Nasal Spray Used For?

Brand name: Spravato

Spravato nasal spray is approved for two uses in adults. First, it treats treatment-resistant depression (TRD) — depression that has not responded to other antidepressants — either on its own or alongside an oral antidepressant. Second, it treats depressive symptoms in adults with major depressive disorder (MDD) who have acute suicidal ideation or behavior, always used together with an oral antidepressant in this case.

Important limits: Spravato has not been shown to prevent suicide or reduce suicidal thoughts or behavior on its own. It is not a replacement for hospitalization if that is clinically needed, and it is not approved as an anesthetic.

Most-Reported Side Effects for Esketamine

From FAERS, the FDA’s public side-effect reporting system (17,728 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dissociation 3,733 reports
Sedation 2,706 reports
Suicidal ideation 1,351 reports
Nausea 957 reports
Depression 873 reports
See full Esketamine Nasal Spray drug information
Keep checking

Other Drugs & Storax

Browse every other medication we’ve checked against Storax — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Storax against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Storax list.

See the full Storax interactions page
See every supplement checked against Esketamine, ranked by severity
Evidence & sources

Storax References

The 2 references that drive our Storax monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Storax and Esketamine Together: Common Questions

Is it safe to take Storax with Esketamine?
We do not list a known interaction between Storax and Esketamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Esketamine interact with any supplements?
Yes. Esketamine has documented interactions with 11 supplements in our database — Storax is not one of them. The Esketamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Storax monograph Uses, safety profile, and every drug interaction in one place Esketamine Nasal Spray drug information The full plain-English guide to this medication Esketamine supplement interactions Every supplement checked against Esketamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Esketamine and Storax?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.