Drug & supplement interaction

1,4-dmaa + Esketamine

Esketamine brand name: Spravato.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between 1,4-dmaa and Esketamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

1,4-dmaa and Esketamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Esketamine and 1,4-dmaa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

1,4-dmaa safety at a glance

1,4-dmaa overall Avoid Banned by the FDA and tied to serious cardiovascular harm; avoid use.
Pregnancy Avoid Not safe; powerful stimulants should be avoided during pregnancy.
Breastfeeding Avoid Not safe; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Esketamine and 1,4-dmaa? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Esketamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Esketamine is filed under 2 classifications — tricyclic antidepressants (tcas), antidepressant drugs. 1,4-dmaa has documented interactions with 1 drug class — the most serious being stimulant drugs (moderate) — and none of Esketamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

1,4-dmaa Does Interact With Other Medications

1,4-dmaa has 172 moderate known drug interactions in our database — Esketamine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Esketamine)
Taking anything else?

Check Another of Your Medications Against 1,4-dmaa

Covers the 2,830 medications we’ve checked against 1,4-dmaa. Pick one to open its full report.

What to actually watch for

What 1,4-dmaa Itself Has Been Linked To

This is not an interaction — nothing below involves Esketamine. It is the side-effect record for 1,4-dmaa on its own, from the licensed Natural Medicines monograph. If something new turns up after you add 1,4-dmaa, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A stroke or mini-stroke Worth acting on Additional detail

    “Orally, clinical evidence on the safety of 1,4-DMAA is lacking, although it has demonstrated stimulant and vasoconstrictive effects in animal studies. A related stimulant called 1,3-DMAA has been linked to serious adverse events in humans, including lactic acidosis, hemorrhagic stroke, heat stroke, and death.”

    1,4-dmaa · Natural Medicines adverse-effect record, reported in stroke.

    6 sources cited
    1. 100692. Cohen PA, Travis JC, Keizers PHJ, Deuster P, Venhuis BJ. Four experimental stimulants found in sports and weight loss supplements: 2-amino-6-methylheptane (octodrine), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3-DMAA) and 1,3-dimethylbuty
    2. 17599. Vorce SP, Holler JM, Cawrse BM, Magluilo J. Dimethylamylamine: A drug causing positive immunoassay results for amphetamines. J Anal Toxicol 2011;35:183-7. PubMed
    3. 17660. Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.
    4. 17662. Starling S. Synthetic geranium substance raises ephedra-like red flags. Nutraingredients-use.com, May 11, 2010. Available at: http://www.nutraingredients-usa.com/Industry/Synthetic-geranium-substance-raises-ephedra-like-red-flags. (Accessed 12 August 2011
    5. 17663. Gee P, Jackson S, Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N Z Med J 2010;123:124-7.
    6. 17904. Removal of the dietary supplement DMAA. Army Medicine, Office of the Surgeon General, 2011. Available at: http://humanperformanceresourcecenter.org/dietary-supplements/files/dmaa-pdf. (Accessed 4 January 2012).

Everything above comes from the Natural Medicines adverse-effect record for 1,4-dmaa — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Esketamine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Esketamine column appears here.

Everything else you take

See Every Supplement That Interacts With Esketamine

This page covers 1,4-dmaa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Esketamine page lists 11 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Scopolia (major), Cowhage (moderate), Dhea (moderate), Griffonia Simplicifolia (moderate) and Indian Snakeroot (moderate).

By severity: 1 major · 6 moderate · 4 minor.

From our pharmacist’s overview on the Esketamine page

“Esketamine (Spravato) is the nasal spray for depression that hasn't responded to standard treatment, and its supplement list deserves genuine respect. Scopolia carries the only major rating and is the entry to understand before any other; pairing it with the medication can raise the risk of anticholinergic effects, meaning dry mouth, b…”

Reviewed by 2 · Jul 18, 2026

Open the Esketamine interaction page

How much people look this up

Where 1,4-dmaa and Esketamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 1,4-dmaa
Top half

#594 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Esketamine
Steady interest

#2,033 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 1,4-dmaa reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The 1,4-dmaa and Esketamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 1,4-dmaa

What is 1,4-dmaa?

  • Energy and stimulation
  • Weight loss
  • Athletic performance
  • Focus and concentration

1,4-DMAA is a synthetic stimulant that the U.S. FDA has determined is not a legal dietary ingredient and considers unsafe in supplements. It has been linked to serious heart and blood pressure problems, and we recommend avoiding it entirely.

Synthetic chemical (not a true plant part) · Capsules, tablets, pre-workout powders

An interaction check asks whether these two react with each other — it does not ask whether 1,4-dmaa is a good idea for someone in your situation. Here is what our 1,4-dmaa record says about it on its own.

1,4-dmaa: dosing

There is no safe or established dose of 1,4-DMAA, and it is not a legal dietary ingredient in the United States. We do not recommend any amount.If you find a product that lists DMAA, 1,4-DMAA, or similar stimulant names on the label, do not take it, and consider reporting it.

From our 1,4-dmaa monograph — the full record covers uses, side effects and every documented interaction.

Read the full 1,4-dmaa monograph & all interactions
Medication

About Esketamine Nasal Spray

What Is Esketamine Nasal Spray Used For?

Brand name: Spravato

Spravato nasal spray is approved for two uses in adults. First, it treats treatment-resistant depression (TRD) — depression that has not responded to other antidepressants — either on its own or alongside an oral antidepressant. Second, it treats depressive symptoms in adults with major depressive disorder (MDD) who have acute suicidal ideation or behavior, always used together with an oral antidepressant in this case.

Important limits: Spravato has not been shown to prevent suicide or reduce suicidal thoughts or behavior on its own. It is not a replacement for hospitalization if that is clinically needed, and it is not approved as an anesthetic.

Most-Reported Side Effects for Esketamine

From FAERS, the FDA’s public side-effect reporting system (17,728 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dissociation 3,733 reports
Sedation 2,706 reports
Suicidal ideation 1,351 reports
Nausea 957 reports
Depression 873 reports
See full Esketamine Nasal Spray drug information
Keep checking

Other Drugs & 1,4-dmaa

Browse every other medication we’ve checked against 1,4-dmaa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the 1,4-dmaa page.

No interaction 2,657 drugs checked — show the list

We also checked 1,4-dmaa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full 1,4-dmaa list.

See the full 1,4-dmaa interactions page
See every supplement checked against Esketamine, ranked by severity
Evidence & sources

1,4-dmaa References

The 9 references that drive our 1,4-dmaa monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Vorce SP, Holler JM, Cawrse BM, Magluilo J. Dimethylamylamine: A drug causing positive immunoassay results for amphetamines. J Anal Toxicol 2011;35:183-7. PubMed
  2. Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.
  3. Starling S. Synthetic geranium substance raises ephedra-like red flags. Nutraingredients-use.com, May 11, 2010. Available at: http://www.nutraingredients-usa.com/Industry/Synthetic-geranium-substance-raises-ephedra-like-red-flags. (Accessed 12 August 2011
  4. Gee P, Jackson S, Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N Z Med J 2010;123:124-7.
  5. Removal of the dietary supplement DMAA. Army Medicine, Office of the Surgeon General, 2011. Available at: http://humanperformanceresourcecenter.org/dietary-supplements/files/dmaa-pdf. (Accessed 4 January 2012).
  6. Archer JR, Dargan PI, Lostia AM, van der Walt J, Henderson K, Drake N, Sharma S, Wood DM, Walker CJ, Kicman AT. Running an unknown risk: a marathon death associated with the use of 1,3-dimethylamylamine (DMAA). Drug Test Anal. 2015 May;7(5):433-8. PubMed
  7. Eliason MJ, Eichner A, Cancio A, Bestervelt L, Adams BD, Deuster PA. Case reports: Death of active duty soldiers following ingestion of dietary supplements containing 1,3-dimethylamylamine (DMAA). Mil Med. 2012 Dec;177(12):1455-9. PubMed
  8. Palmer PG Jr. Deadly dimethylamylamine: "health" supplements are killing consumers while current regulations impede FDA action. J Leg Med. 2014;35(2):311-36. PubMed
  9. Cohen PA, Travis JC, Keizers PHJ, Deuster P, Venhuis BJ. Four experimental stimulants found in sports and weight loss supplements: 2-amino-6-methylheptane (octodrine), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3-DMAA) and 1,3-dimethylbuty

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 1,4-dmaa and Esketamine Together: Common Questions

Is it safe to take 1,4-dmaa with Esketamine?
We do not list a known interaction between 1,4-dmaa and Esketamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the 1,4-dmaa and Esketamine combination checked?
Interactions in our licensed database are recorded against drug classes. Esketamine is filed under 2 classifications, and 1,4-dmaa has documented interactions with 1 drug class — none of Esketamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 1,4-dmaa interact with any other medications?
Yes. 1,4-dmaa has 172 documented drug interactions in our database — Esketamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Esketamine interact with any supplements?
Yes. Esketamine has documented interactions with 11 supplements in our database — 1,4-dmaa is not one of them. The Esketamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

1,4-dmaa monograph Uses, safety profile, and every drug interaction in one place Esketamine Nasal Spray drug information The full plain-English guide to this medication Esketamine supplement interactions Every supplement checked against Esketamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Esketamine and 1,4-dmaa?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.