Drug & supplement interaction

Quinoa + Esketamine

Esketamine brand name: Spravato.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Quinoa and Esketamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Quinoa and Esketamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Esketamine and Quinoa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Quinoa at all — not against Esketamine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Quinoa safety at a glance

Quinoa overall Generally safe Quinoa is widely eaten as a food and is generally safe for most people.
Pregnancy Likely Safe When used orally in food amounts. There is insufficient reliable information available about the safety of quinoa in medicinal amounts; avoid using. Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in food amounts. There is insufficient reliable information available about the safety of quinoa in medicinal amounts; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Esketamine and Quinoa? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Quinoa Itself Has Been Linked To

This is not an interaction — nothing below involves Esketamine. It is the side-effect record for Quinoa on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Quinoa, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction / An allergic reaction Worth acting on Additional detail

    “Orally, allergic reactions to quinoa have been reported. Anaphylaxis and pruritic reactions have occurred in at least two individuals, a 29-year-old female and a 52-year-old male. Quinoa allergy was confirmed in both patients via skin-prick testing with quinoa extract.”

    Quinoa · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    3 sources cited
    1. 99150. Hong J, Convers K, Reeves N, Temprano J. Anaphylaxis to quinoa. Ann Allergy Asthma Immunol. 2013;110(1):60-1. PubMed
    2. 96062. El-Qutob López D, Bartolomé Zavala B, Ortiz I. Cross-reactivity between buckwheat and quinoa in a patient with eosinophilic esophagitis caused by wheat. J Investig Allergol Clin Immunol. 2014;24(1):56-7.
    3. 99151. Astier C, Moneret-Vautrin DA, Puillandre E, Bihain BE. First case report of anaphylaxis to quinoa, a novel food in France. Allergy. 2009;64(5):819-20. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Quinoa — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Esketamine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Esketamine column appears here.

Special populations

Quinoa in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in food amounts. There is insufficient reliable information available about the safety of quinoa in medicinal amounts; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Esketamine

This page covers Quinoa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Esketamine page lists 11 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Scopolia (major), Cowhage (moderate), Dhea (moderate), Griffonia Simplicifolia (moderate) and Indian Snakeroot (moderate).

By severity: 1 major · 6 moderate · 4 minor.

From our pharmacist’s overview on the Esketamine page

“Esketamine (Spravato) is the nasal spray for depression that hasn't responded to standard treatment, and its supplement list deserves genuine respect. Scopolia carries the only major rating and is the entry to understand before any other; pairing it with the medication can raise the risk of anticholinergic effects, meaning dry mouth, b…”

Reviewed by 2 · Jul 18, 2026

Open the Esketamine interaction page

One more smart check

Taking Quinoa as Part of a Dietary Supplement Product? Check It for Interactions

We hold 699 real supplement products containing Quinoa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Quinoa. Even though Quinoa itself has no known interaction with Esketamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Quinoa and Esketamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Quinoa
Top 25%

#359 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Esketamine
Steady interest

#1,878 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Quinoa reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Quinoa and Esketamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Quinoa

What is Quinoa?

  • Gluten-free grain alternative
  • Plant-based protein source
  • Heart and cholesterol health
  • Blood sugar support
  • Digestive and fiber intake
  • Weight management

Quinoa is a nutritious, gluten-free seed eaten like a grain, rich in protein, fiber, and minerals. It is best thought of as a healthy food rather than a medicine, and most people can enjoy it safely as part of a balanced diet.

Chenopodium quinoa · Amaranthaceae · Seeds (whole grain); leaves are sometimes eaten as a vegetable · Whole cooked seeds, flour, flakes, puffed cereal, and protein powders

An interaction check asks whether these two react with each other — it does not ask whether Quinoa is a good idea for someone in your situation. Here is what our Quinoa record says about it on its own.

Quinoa: dosing

There is no official medicinal dose for quinoa because it is a food, not a standardized supplement. Most people simply eat it as a serving of cooked grain, similar to rice or pasta.If you use a quinoa-based product such as flour, flakes, or a protein powder, follow the directions on the package.

From our Quinoa monograph — the full record covers uses, side effects and every documented interaction.

Read the full Quinoa monograph & all interactions
Medication

About Esketamine Nasal Spray

What Is Esketamine Nasal Spray Used For?

Brand name: Spravato

Spravato nasal spray is approved for two uses in adults. First, it treats treatment-resistant depression (TRD) — depression that has not responded to other antidepressants — either on its own or alongside an oral antidepressant. Second, it treats depressive symptoms in adults with major depressive disorder (MDD) who have acute suicidal ideation or behavior, always used together with an oral antidepressant in this case.

Important limits: Spravato has not been shown to prevent suicide or reduce suicidal thoughts or behavior on its own. It is not a replacement for hospitalization if that is clinically needed, and it is not approved as an anesthetic.

Most-Reported Side Effects for Esketamine

From FAERS, the FDA’s public side-effect reporting system (17,728 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dissociation 3,733 reports
Sedation 2,706 reports
Suicidal ideation 1,351 reports
Nausea 957 reports
Depression 873 reports
See full Esketamine Nasal Spray drug information
Keep checking

Other Drugs & Quinoa

Browse every other medication we’ve checked against Quinoa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Quinoa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Quinoa list.

See the full Quinoa interactions page
See every supplement checked against Esketamine, ranked by severity
Evidence & sources

Quinoa References

The 5 references that drive our Quinoa monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. El-Qutob López D, Bartolomé Zavala B, Ortiz I. Cross-reactivity between buckwheat and quinoa in a patient with eosinophilic esophagitis caused by wheat. J Investig Allergol Clin Immunol. 2014;24(1):56-7.
  2. Li L, Lietz G, Bal W, Watson A, Morfey B, Seal C. Effects of quinoa (Chenopodium quinoa Willd.) consumption on markers of CVD risk. Nutrients. 2018;10(6). pii: E777. PubMed
  3. De Carvalho FG, Ovídio PP, Padovan GJ, Jordão Junior AA, Marchini JS, Navarro AM. Metabolic parameters of postmenopausal women after quinoa or corn flakes intake--a prospective and double-blind study. Int J Food Sci Nutr. 2014;65(3):380-5. PubMed
  4. Hong J, Convers K, Reeves N, Temprano J. Anaphylaxis to quinoa. Ann Allergy Asthma Immunol. 2013;110(1):60-1. PubMed
  5. Astier C, Moneret-Vautrin DA, Puillandre E, Bihain BE. First case report of anaphylaxis to quinoa, a novel food in France. Allergy. 2009;64(5):819-20. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Quinoa and Esketamine Together: Common Questions

Is it safe to take Quinoa with Esketamine?
We do not list a known interaction between Quinoa and Esketamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Esketamine interact with any supplements?
Yes. Esketamine has documented interactions with 11 supplements in our database — Quinoa is not one of them. The Esketamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Quinoa monograph Uses, safety profile, and every drug interaction in one place Esketamine Nasal Spray drug information The full plain-English guide to this medication Esketamine supplement interactions Every supplement checked against Esketamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Esketamine and Quinoa?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.