Drug & supplement interaction

Dragon Fruit + Esketamine

Esketamine brand name: Spravato.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Dragon Fruit and Esketamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Dragon Fruit and Esketamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Esketamine and Dragon Fruit in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dragon Fruit safety at a glance

Dragon Fruit overall Generally safe Dragon fruit is widely eaten as a food and is generally safe for most people.
Pregnancy Use caution The fruit as food is generally fine, but concentrated supplements or extracts have not been studied in pregnancy, so use caution.
Breastfeeding Use caution The fruit is considered fine in normal food amounts, but supplement forms lack safety data, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Esketamine and Dragon Fruit? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Esketamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Esketamine is filed under 2 classifications — tricyclic antidepressants (tcas), antidepressant drugs. Dragon Fruit has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Esketamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Dragon Fruit Does Interact With Other Medications

Dragon Fruit has 86 moderate known drug interactions in our database — Esketamine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Esketamine)
Taking anything else?

Check Another of Your Medications Against Dragon Fruit

Covers the 2,830 medications we’ve checked against Dragon Fruit. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Dragon Fruit and Esketamine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting Additional detail

    Dragon Fruit

    “Allergy to dragon fruit has been reported in case reports with symptoms including vomiting, swollen tongue, skin redness, and hives.”

    Dragon Fruit · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 93930. Kleinheinz A, Lepp U, Hausen BM, Petersen A, Becker WM. Anaphylactic reaction to (mixed) fruit juice containing dragon fruit. J Allergy Clin Immunol. 2009 Oct;124(4):841-2. PubMed

    Esketamine

    Listed in the ADVERSE REACTIONS section of the FDA label for Esketamine. Read the label on DailyMed ›

Reported for Dragon Fruit but not commonly for Esketamine: hives.

Effects for Esketamine come from the ADVERSE REACTIONS section of its FDA label; effects for Dragon Fruit come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 17,728 voluntary FDA FAERS reports for Esketamine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Esketamine

This page covers Dragon Fruit only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Esketamine page lists 11 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Scopolia (major), Cowhage (moderate), Dhea (moderate), Griffonia Simplicifolia (moderate) and Indian Snakeroot (moderate).

By severity: 1 major · 6 moderate · 4 minor.

From our pharmacist’s overview on the Esketamine page

“Esketamine (Spravato) is the nasal spray for depression that hasn't responded to standard treatment, and its supplement list deserves genuine respect. Scopolia carries the only major rating and is the entry to understand before any other; pairing it with the medication can raise the risk of anticholinergic effects, meaning dry mouth, b…”

Reviewed by 2 · Jul 18, 2026

Open the Esketamine interaction page

One more smart check

Taking Dragon Fruit as Part of a Dietary Supplement Product? Check It for Interactions

We hold 13 real supplement products containing Dragon Fruit, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dragon Fruit. Even though Dragon Fruit itself has no known interaction with Esketamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dragon Fruit and Esketamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dragon Fruit
Steady interest

#856 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Esketamine
Steady interest

#1,947 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dragon Fruit reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Dragon Fruit and Esketamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dragon Fruit

What is Dragon Fruit?

  • General nutrition and antioxidant support
  • Digestive health and regularity
  • Blood sugar support
  • Heart and cholesterol health
  • Immune support

Dragon fruit is a colorful tropical fruit that is a nutritious, low-calorie source of fiber, vitamin C, and antioxidants. It is safe and healthy to eat as a food for most people, but strong human evidence that supplements or extracts treat any disease is lacking. Enjoy it as part of a balanced diet, and talk to your pharmacist before using concentrated supplements.

Hylocereus undatus · Cactaceae · Fruit (pulp and seeds); sometimes flower and peel · Fresh fruit, juice, smoothies, dried fruit, powder, capsules, and supplements

An interaction check asks whether these two react with each other — it does not ask whether Dragon Fruit is a good idea for someone in your situation. Here is what our Dragon Fruit record says about it on its own.

Dragon Fruit: dosing

There is no official or standardized dose of dragon fruit. As a food, it is simply eaten in normal serving sizes, like any other fruit.For supplements, powders, or capsules, there is no proven effective dose. If you choose to use a product, follow the directions on the label and do not exceed the recommended amount.

From our Dragon Fruit monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dragon Fruit monograph & all interactions
Medication

About Esketamine Nasal Spray

What Is Esketamine Nasal Spray Used For?

Brand name: Spravato

Spravato nasal spray is approved for two uses in adults. First, it treats treatment-resistant depression (TRD) — depression that has not responded to other antidepressants — either on its own or alongside an oral antidepressant. Second, it treats depressive symptoms in adults with major depressive disorder (MDD) who have acute suicidal ideation or behavior, always used together with an oral antidepressant in this case.

Important limits: Spravato has not been shown to prevent suicide or reduce suicidal thoughts or behavior on its own. It is not a replacement for hospitalization if that is clinically needed, and it is not approved as an anesthetic.

Most-Reported Side Effects for Esketamine

From FAERS, the FDA’s public side-effect reporting system (17,728 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dissociation 3,733 reports
Sedation 2,706 reports
Suicidal ideation 1,351 reports
Nausea 957 reports
Depression 873 reports
See full Esketamine Nasal Spray drug information
Keep checking

Other Drugs & Dragon Fruit

Browse every other medication we’ve checked against Dragon Fruit — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Dragon Fruit page.

No interaction 2,743 drugs checked — show the list

We also checked Dragon Fruit against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Dragon Fruit list.

See the full Dragon Fruit interactions page
See every supplement checked against Esketamine, ranked by severity
Evidence & sources

Dragon Fruit References

The 2 references that drive our Dragon Fruit monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kleinheinz A, Lepp U, Hausen BM, Petersen A, Becker WM. Anaphylactic reaction to (mixed) fruit juice containing dragon fruit. J Allergy Clin Immunol. 2009 Oct;124(4):841-2. PubMed
  2. Poolsup N, Suksomboon N, Paw NJ. Effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis. PLoS One. 2017;12(9):e0184577. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dragon Fruit and Esketamine Together: Common Questions

Is it safe to take Dragon Fruit with Esketamine?
We do not list a known interaction between Dragon Fruit and Esketamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Dragon Fruit and Esketamine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Dragon Fruit and Esketamine combination checked?
Interactions in our licensed database are recorded against drug classes. Esketamine is filed under 2 classifications, and Dragon Fruit has documented interactions with 1 drug class — none of Esketamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Dragon Fruit interact with any other medications?
Yes. Dragon Fruit has 86 documented drug interactions in our database — Esketamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Esketamine interact with any supplements?
Yes. Esketamine has documented interactions with 11 supplements in our database — Dragon Fruit is not one of them. The Esketamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Dragon Fruit monograph Uses, safety profile, and every drug interaction in one place Esketamine Nasal Spray drug information The full plain-English guide to this medication Esketamine supplement interactions Every supplement checked against Esketamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Esketamine and Dragon Fruit?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.