Drug & supplement interaction

Bogbean + Zonisamide

Zonisamide brand names: Zonegran, Zonisade.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Bogbean and Zonisamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Bogbean and Zonisamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Zonisamide and Bogbean in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Bogbean at all — not against Zonisamide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bogbean safety at a glance

Bogbean overall Use caution Limited safety data; large doses may cause stomach upset, nausea, vomiting, or diarrhea.
Pregnancy Possibly Unsafe When used orally due to the lack of toxicity information and its possible purgative action; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally due to the lack of toxicity information and its possible purgative action; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Zonisamide and Bogbean? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Bogbean and Zonisamide May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea / Vomiting / Nausea reported in 3.9% of FDA reports for Zonisamide Additional detail

    Bogbean

    “Orally, bogbean seems to be generally well tolerated (4). Excessive doses of bogbean can irritate the GI tract, and cause diarrhea, pain, nausea, and vomiting (4).”

    Bogbean · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

    “Orally, excessive doses of bogbean can irritate the GI tract and cause diarrhea, pain, nausea, and vomiting (4).”

    Bogbean · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

    Zonisamide

    Listed in the ADVERSE REACTIONS section of the FDA label for Zonisamide, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Zonisamide come from the ADVERSE REACTIONS section of its FDA label; effects for Bogbean come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 14,486 voluntary FDA FAERS reports for Zonisamide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Bogbean in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally due to the lack of toxicity information and its possible purgative action; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Zonisamide

This page covers Bogbean only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Zonisamide page lists 206 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 157 moderate · 40 minor.

From our pharmacist’s overview on the Zonisamide page

“Zonisamide (Zonegran, Zonisade) keeps seizures under control, which means anything that shifts its blood level or stacks extra sedation on top deserves real respect, and nine of the 206 supplement ingredients on file rate major. Two big themes run through nearly everything here.”

Reviewed by 2 · Jul 18, 2026

Open the Zonisamide interaction page

One more smart check

Taking Bogbean as Part of a Dietary Supplement Product? Check It for Interactions

We hold 11 real supplement products containing Bogbean, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bogbean. Even though Bogbean itself has no known interaction with Zonisamide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bogbean and Zonisamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bogbean
Steady interest

#831 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Zonisamide
Steady interest

#1,455 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bogbean reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Bogbean and Zonisamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bogbean

What is Bogbean?

  • Rheumatoid arthritis and joint pain
  • Poor appetite and digestive upset
  • Bitter tonic
  • Scurvy (traditional)
  • Fever (traditional)

Bogbean is a wetland plant whose bitter leaves have long been used in folk medicine for joint pain, poor appetite, and digestion. Good-quality human studies are lacking, so its benefits are unproven, and large amounts can upset the stomach. Talk with a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Menyanthes trifoliata · Menyanthaceae · Leaves (and sometimes the roots/rhizome) · Tea, tincture, liquid extract, capsules, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Bogbean is a good idea for someone in your situation. Here is what our Bogbean record says about it on its own.

Bogbean: dosing

There is no well-established, standardized dose for bogbean. Traditional use typically involves small amounts of the dried leaf as a tea or a measured dose of tincture or extract.Because strengths vary widely between products, the safest approach is to follow the directions on the product label and not exceed the recommended amount. More is not better with this bitter herb, since larger doses are more likely to cause stomach upset.

From our Bogbean monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bogbean monograph & all interactions
Medication

About Zonisamide

What Is Zonisamide Used For?

Brand names: Zonegran, Zonisade

Zonisamide is used as add-on therapy — meaning it is combined with other seizure medications, not used alone — to treat partial seizures (seizures that start in one part of the brain) in adults with epilepsy. Zonegran (capsule) and generic zonisamide capsules are approved for adults with epilepsy.

Zonisade (oral suspension) is approved as add-on therapy for partial-onset seizures in adults and in patients 16 years of age and older.

See full Zonisamide drug information
Keep checking

Other Drugs & Bogbean

Browse every other medication we’ve checked against Bogbean — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Bogbean against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Bogbean list.

See the full Bogbean interactions page
See every supplement checked against Zonisamide, ranked by severity
Evidence & sources

Bogbean References

The 1 references that drive our Bogbean monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bogbean and Zonisamide Together: Common Questions

Is it safe to take Bogbean with Zonisamide?
We do not list a known interaction between Bogbean and Zonisamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Bogbean and Zonisamide have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Zonisamide interact with any supplements?
Yes. Zonisamide has documented interactions with 206 supplements in our database — Bogbean is not one of them. The Zonisamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bogbean monograph Uses, safety profile, and every drug interaction in one place Zonisamide drug information The full plain-English guide to this medication Zonisamide supplement interactions Every supplement checked against Zonisamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Zonisamide and Bogbean?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.