Drug & supplement interaction

Burning Bush + Alogliptin, Metformin

Alogliptin, Metformin brand name: Kazano.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Burning Bush and Alogliptin, Metformin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Alogliptin, Metformin states a food rule worth keeping to.

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Interaction report

Burning Bush and Alogliptin, Metformin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Alogliptin, Metformin and Burning Bush in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Burning Bush at all — not against Alogliptin, Metformin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Burning Bush safety at a glance

Burning Bush overall Use caution The plant contains potentially toxic compounds and lacks safety data, so use with great caution or avoid.
Pregnancy Avoid Historically used to affect the uterus and considered unsafe; avoid during pregnancy.
Breastfeeding Avoid No safety data are available, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Alogliptin, Metformin and Burning Bush? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Alogliptin, Metformin’s Own FDA Label Lists

This is not an interaction — none of it involves Burning Bush. These are the most notable effects listed in the ADVERSE REACTIONS section of Alogliptin, Metformin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A bowel blockage Worth acting on
  • Severe muscle breakdown Worth acting on
  • Low blood sugar Worth acting on
  • Pancreatitis Worth acting on
  • Heart failure Worth acting on
  • High blood sugar Worth acting on
  • A severe skin reaction Worth acting on
  • Kidney problems Worth acting on
  • Raised blood pressure Worth acting on
  • A severe allergic reaction Worth acting on

Showing the 10 most notable of 25 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Alogliptin, Metformin. Read the label on DailyMed › Burning Bush’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Burning Bush side to compare — that is a limit of the record, not a statement that Burning Bush has no side effects.

How to take them

Some Alogliptin, Metformin Products Have a Food Rule — Burning Bush Should Not Break It

At least one FDA label for a product containing Alogliptin, Metformin says to take it with food. If you take Burning Bush on an empty stomach out of habit, keep them separate — and take Alogliptin, Metformin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Alogliptin, Metformin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 ) Given orally twice daily with food.

From the Dosage and Administration section of the FDA label we read for Alogliptin, Metformin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Alogliptin, Metformin

This page covers Burning Bush only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Alogliptin, Metformin page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 217 moderate · 38 minor.

From our pharmacist’s overview on the Alogliptin, Metformin page

“Kazano combines alogliptin and metformin to lower blood sugar, and nearly everything on this list pushes on that same lever, so I treat these pairings with real caution. Most entries are herbs and supplements that lower glucose on their own, and stacked on the drug they raise the risk of hypoglycemia, a sugar drop steep enough to cause…”

Reviewed by 2 · Jul 18, 2026

Open the Alogliptin, Metformin interaction page

One more smart check

Taking Burning Bush as Part of a Dietary Supplement Product? Check It for Interactions

We hold 6 real supplement products containing Burning Bush, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Burning Bush. Even though Burning Bush itself has no known interaction with Alogliptin, Metformin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Burning Bush and Alogliptin, Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Burning Bush
Steady interest

#1,270 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Alogliptin, Metformin
Top half

#862 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Burning Bush and Alogliptin, Metformin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Burning Bush

What is Burning Bush?

  • Constipation
  • Liver and gallbladder complaints
  • Fluid retention
  • Skin conditions
  • Traditional 'blood cleansing'

Burning Bush (Euonymus atropurpureus), also called wahoo, is a traditional North American remedy historically used as a laxative and 'liver tonic.' There is very little modern scientific evidence to support these uses, and the plant contains compounds that can be toxic, so it is generally not recommended for self-treatment.

Euonymus atropurpureus · Celastraceae · Bark (root bark and stem bark) · Dried bark, powder, tincture, capsules, tea

An interaction check asks whether these two react with each other — it does not ask whether Burning Bush is a good idea for someone in your situation. Here is what our Burning Bush record says about it on its own.

Burning Bush: dosing

There is no established, standardized safe dose for Burning Bush. It is not a well-studied modern supplement, and the strength of bark products can vary widely.Because of the risk of toxicity, we do not provide specific amounts. For common problems like constipation, there are safer and better-studied options available.

From our Burning Bush monograph — the full record covers uses, side effects and every documented interaction.

Read the full Burning Bush monograph & all interactions
Keep checking

Other Drugs & Burning Bush

Browse every other medication we’ve checked against Burning Bush — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Burning Bush against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Burning Bush list.

See the full Burning Bush interactions page
See every supplement checked against Alogliptin, Metformin, ranked by severity
Sources

Sources & How We Checked

We checked Burning Bush against Alogliptin, Metformin in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Burning Bush monograph › Uses, safety, and every drug interaction in one place Alogliptin, Metformin supplement interactions › Every supplement checked against Alogliptin, Metformin, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Burning Bush and Alogliptin, Metformin Together: Common Questions

Is it safe to take Burning Bush with Alogliptin, Metformin?
We do not list a known interaction between Burning Bush and Alogliptin, Metformin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Burning Bush and Alogliptin, Metformin at the same time of day?
At least one FDA label for a product containing Alogliptin, Metformin says to take it with food. If you take Burning Bush on an empty stomach out of habit, keep them separate and take Alogliptin, Metformin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Alogliptin, Metformin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Alogliptin, Metformin interact with any supplements?
Yes. Alogliptin, Metformin has documented interactions with 257 supplements in our database — Burning Bush is not one of them. The Alogliptin, Metformin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Alogliptin, Metformin and Burning Bush?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.