Drug & supplement interaction

Calendula + Carbidopa

Carbidopa brand name: Lodosyn.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Calendula and Carbidopa in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Calendula and Carbidopa

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Carbidopa and Calendula in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Calendula safety at a glance

Calendula overall Use caution Generally well tolerated on the skin, but can cause allergic reactions in sensitive people.
Pregnancy Likely Unsafe When used orally; contraindicated due to spermatocide, antiblastocyst, and abortifacient effects. There is insufficient reliable information available about the... Read the full pregnancy detail
Breastfeeding Use caution Reliable safety information is lacking, so it is best to avoid oral use unless your doctor approves.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Carbidopa and Calendula? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Carbidopa

Interactions in our licensed database are recorded against drug classes, not just single drug names. Carbidopa is filed under 3 classifications — including oral drugs. Calendula has documented interactions with 1 drug class — the most serious being cns depressants (minor) — and none of Carbidopa’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Calendula Does Interact With Other Medications

Calendula has 248 minor known drug interactions in our database — Carbidopa isn’t one of them. If you take anything else, check it against the full list below.

Minor 248 No known interaction 2,582 (incl. Carbidopa)
Taking anything else?

Check Another of Your Medications Against Calendula

Covers the 2,830 medications we’ve checked against Calendula. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Calendula and Carbidopa May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • A severe allergic reaction / Hives / An allergic reaction Worth acting on Additional detail

    Calendula

    “Orally, calendula can cause allergic reactions. Topically, calendula can cause eczematous allergic reactions. Calendula-specific patch testing is recommended prior to usage to determine allergenic potential. Testing is particularly necessary in individuals sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many other herbs.”

    Calendula · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    4 sources cited
    1. 10691. Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72..
    2. 11458. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. PubMed
    3. 96647. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
    4. 11152. Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3.

    Carbidopa

    Listed in the ADVERSE REACTIONS section of the FDA label for Carbidopa. Read the label on DailyMed ›

  • Itching Additional detail

    Calendula

    “Topically, a preparation containing calendula powder 0.1% resulted in inflammation around the wound to which it was applied. Burning sensation, itching, redness, and scaling were reported rarely in patients applying a combination of calendula, licorice, and snail secretion filtrate to the face. The specific role of calendula is unclear.”

    Calendula · Natural Medicines adverse-effect record, reported in pruritus.

    2 sources cited
    1. 96647. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
    2. 110322. Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A

    Carbidopa

    Listed in the ADVERSE REACTIONS section of the FDA label for Carbidopa. Read the label on DailyMed ›

Effects for Carbidopa come from the ADVERSE REACTIONS section of its FDA label; effects for Calendula come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 52,609 voluntary FDA FAERS reports for Carbidopa that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Calendula in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally; contraindicated due to spermatocide, antiblastocyst, and abortifacient effects. There is insufficient reliable information available about the safety of calendula when used topically during pregnancy.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Calendula or Carbidopa

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Calendula or Carbidopa, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Carbidopa

This page covers Calendula only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Carbidopa page lists 21 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Magnesium (major), 5-htp (moderate), Coffee Charcoal (moderate) and European Mandrake (moderate).

By severity: 2 major · 10 moderate · 9 minor.

From our pharmacist’s overview on the Carbidopa page

“Carbidopa (Lodosyn) keeps levodopa working in Parkinson's disease, so anything that blocks its absorption can cost real motor control, and two of the 21 supplements on this list do exactly that at a level rated major. Magnesium is the one that surprises people: in a human study it cut carbidopa absorption by 81 percent and levodopa's b…”

Reviewed by 2 · Jul 18, 2026

Open the Carbidopa interaction page

One more smart check

Taking Calendula as Part of a Dietary Supplement Product? Check It for Interactions

We hold 214 real supplement products containing Calendula, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Calendula. Even though Calendula itself has no known interaction with Carbidopa, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Calendula and Carbidopa Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Calendula
Top half

#534 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Carbidopa
Top half

#963 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Calendula reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Calendula and Carbidopa records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Calendula

What is Calendula?

Calendula
  • Minor wounds and skin healing
  • Skin inflammation and irritation
  • Diaper rash
  • Mouth and throat inflammation
  • Soothing dry or chapped skin

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing. Some early research is promising for skin and mouth uses, but the overall evidence is limited. It is generally well tolerated on the skin, but people allergic to ragweed, daisies, or marigolds should be cautious.

Calendula officinalis · Asteraceae · Flowers (petals/florets) · Topical creams, ointments, gels, oils, tinctures, teas, mouth rinses

An interaction check asks whether these two react with each other — it does not ask whether Calendula is a good idea for someone in your situation. Here is what our Calendula record says about it on its own.

Calendula: dosing

There is no official, standardized dose for calendula. The amount used depends on the product and how it is being used, such as a cream, oil, tincture, or tea.The best approach is to follow the directions on the product label and to choose products from reputable brands.

From our Calendula monograph — the full record covers uses, side effects and every documented interaction.

Read the full Calendula monograph & all interactions
Medication

About Carbidopa

What Is Carbidopa Used For?

Brand name: Lodosyn

Carbidopa tablets — sold under the brand name Lodosyn and as generic carbidopa — are used together with levodopa or carbidopa-levodopa to manage symptoms of Parkinson's disease, postencephalitic parkinsonism, and symptomatic parkinsonism that can result from carbon monoxide or manganese poisoning. Carbidopa is never used alone; it always works as a partner to levodopa-based therapy.

Lodosyn is specifically used when a patient taking carbidopa-levodopa isn't getting enough daily carbidopa from that combination, or when a patient needs the two drugs individually titrated (adjusted) rather than taken as a fixed combination. Adding carbidopa helps reduce the nausea and vomiting that levodopa often causes and allows lower doses of levodopa to be used.

Most-Reported Side Effects for Carbidopa

From FAERS, the FDA’s public side-effect reporting system (52,609 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fall 4,954 reports
Hallucination 4,554 reports
Tremor 3,533 reports
Dyskinesia 3,174 reports
Dizziness 2,837 reports
See full Carbidopa drug information
Keep checking

Other Drugs & Calendula

Browse every other medication we’ve checked against Calendula — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
248Minor
2,581No known interaction
248 Minor 2,581 No interaction
Minor

248 interactions

Showing 60 of 248 minor interactions — see all 248 on the Calendula page.

No interaction 2,581 drugs checked — show the list

We also checked Calendula against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Calendula list.

See the full Calendula interactions page
See every supplement checked against Carbidopa, ranked by severity
Evidence & sources

Calendula References

The 9 references that drive our Calendula monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72..
  3. Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3.
  4. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. PubMed
  5. Bojadjiev C. On the sedative and hypotensive effect of preparations from the plant Calendula officinalis. Nauch Trud Visshi Med Inst Sof 1964;43:15-20.
  6. Samochowiec L. Pharmacological study of saponosides from Aralia mandshurica Rupr. et Maxim and Calendula officinalis L. Herba Pol. 1983;29:151-155.
  7. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
  8. Final Assessment report on Calendula officinalis L., flos. European Medicines Agency: Committee on Herbal Medicinal Products (HMPC). 2018. EMA/HMPC/603409/2017. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-cal
  9. Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Calendula and Carbidopa Together: Common Questions

Is it safe to take Calendula with Carbidopa?
We do not list a known interaction between Calendula and Carbidopa. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Calendula and Carbidopa have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Calendula and Carbidopa combination checked?
Interactions in our licensed database are recorded against drug classes. Carbidopa is filed under 3 classifications, and Calendula has documented interactions with 1 drug class — none of Carbidopa's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Calendula interact with any other medications?
Yes. Calendula has 248 documented drug interactions in our database — Carbidopa is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Carbidopa interact with any supplements?
Yes. Carbidopa has documented interactions with 21 supplements in our database — Calendula is not one of them. The Carbidopa interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Calendula monograph Uses, safety profile, and every drug interaction in one place Carbidopa drug information The full plain-English guide to this medication Carbidopa supplement interactions Every supplement checked against Carbidopa, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Carbidopa and Calendula?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.