Drug & supplement interaction

Chlorine Dioxide + Desflurane

Desflurane brand name: Suprane.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chlorine Dioxide and Desflurane in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Chlorine Dioxide and Desflurane

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Desflurane and Chlorine Dioxide in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Chlorine Dioxide at all — not against Desflurane, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chlorine Dioxide safety at a glance

Chlorine Dioxide overall Avoid Drinking chlorine dioxide products is dangerous and can cause life-threatening harm; the FDA warns against their use.
Pregnancy Likely Unsafe When used orally for medicinal purposes. Chlorine dioxide supplement products typically contain 28% sodium chlorite, which can provide 3-8 mg of chlorine dioxid... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally for medicinal purposes. Chlorine dioxide supplement products typically contain 28% sodium chlorite, which can provide 3-8 mg of chlorine dioxid... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Desflurane and Chlorine Dioxide? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Chlorine Dioxide and Desflurane May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Yellowing of the skin or eyes Worth acting on Additional detail

    Chlorine Dioxide

    “Orally, chlorine dioxide has been reported to cause hemolysis. In one case series, two healthy adults presented with reddish urine, jaundice, tachycardia, and tachypnea three days after ingesting 100 mL each of chlorine dioxide 2% solution. Hemolysis resolved after 7 days. Patients with G6PD deficiency are at increased risk for hemolysis with chlorine dioxide.”

    Chlorine Dioxide · Natural Medicines adverse-effect record, reported in anemia.

    5 sources cited
    1. 102807. Kishan H. Chlorine dioxide-induced acute hemolysis. J Med Toxicol. 2009 Sep;5(3):177.
    2. 102809. Moore GS, Calabrese EJ, Ho SC. Groups at potentially high risk from chlorine dioxide treated water. J Environ Pathol Toxicol. 1980 Sep;4(2-3):465-70.
    3. 102820. Burke D, Zakhary B, Pinelis E. Acute Hemolysis Following an Overdose of Miracle Mineral Solution in a Patient With Normal Glucose-6-Phosphate Dehydrogenase Levels. Chest. 2014;146(4_MeetingAbstracts):273A. DOI
    4. 108746. Medina-Avitia E, Tella-Vega P, García-Estrada C. Acute kidney injury secondary to chlorine dioxide use for COVID-19 prevention. Hemodial Int. 2021 Oct;25(4):E40-E43. PubMed
    5. 108747. Lardieri A, Cheng C, Jones SC, McCulley L. Harmful effects of chlorine dioxide exposure. Clin Toxicol (Phila). 2021 May;59(5):448-9. PubMed

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • Kidney problems Worth acting on Additional detail

    Chlorine Dioxide

    “A 55-year-old male who took an unknown dose of chlorine dioxide orally daily for 5 days as prophylaxis for COVID-19, presented with nausea and vomiting, dehydration, altered mental status, disseminated intravascular coagulation, and acute kidney injury requiring hemodialysis.”

    Chlorine Dioxide · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 108746. Medina-Avitia E, Tella-Vega P, García-Estrada C. Acute kidney injury secondary to chlorine dioxide use for COVID-19 prevention. Hemodial Int. 2021 Oct;25(4):E40-E43. PubMed

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Chlorine Dioxide

    “Orally, chlorine dioxide solution in doses of up to 10 mL diluted in 1 liter of water, consumed over 8 hours daily for 9 months, has resulted in fatal toxicity. A 65-year-old male presented with nausea and vomiting, melena, drowsiness, hypotension, tachycardia, electrolyte imbalance, peritoneal irritation, absent peristalsis, abdominal distension due to fluid accumulation, and perforation of the jejunum.”

    Chlorine Dioxide · Natural Medicines adverse-effect record, reported in hypotension.

    2 sources cited
    1. 108748. Arellano-Gutiérrez G, Aldana-Zaragoza EH, Pérez-Fabián A. Intestinal perforation associated with chlorine dioxide ingestion: an adult chronic consumer during COVID-19 pandemic. Clin J Gastroenterol. 2021 Dec;14(6):1655-60. PubMed
    2. 102808. Loh JM, Shafi H. Kikuchi-Fujimoto disease presenting after consumption of 'Miracle Mineral Solution' (sodium chlorite). BMJ Case Rep. 2014 Nov 24;2014:bcr2014205832. PubMed

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • Low blood pressure Additional detail

    Chlorine Dioxide

    “Orally, consuming large quantities of chlorine dioxide has been reported to cause life-threatening hypotension.”

    Chlorine Dioxide · Natural Medicines adverse-effect record, reported in hypotension.

    1 source cited
    1. 102810. FDA. Danger: Don't Drink Miracle Mineral Solution or Similar Products. Available at: https://www.fda.gov/consumers/consumer-updates/danger-dont-drink-miracle-mineral-solution-or-similar-products?utm_campaign=FDA%20warns%20consumers%20about%20the%20dangero

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • Fever Additional detail

    Chlorine Dioxide

    Recorded for Chlorine Dioxide in the same Natural Medicines adverse-effect record shown under A fast or pounding heartbeat above.

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • Vomiting Additional detail

    Chlorine Dioxide

    “Orally, consuming chlorine dioxide in quantities exceeding the maximum allowable concentration can irritate the mouth, esophagus, and stomach. Consuming large quantities of chlorine dioxide has been reported to cause severe vomiting and diarrhea.”

    Chlorine Dioxide · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 102811. Agency for Toxic Substances and Disease Registry (ATSDR). ToxFAQs for Chlorine Dioxide and Chlorite. September 2004. Available at: https://www.atsdr.cdc.gov/toxfaqs/tfacts160.pdf. Accessed on May 4, 2020.
    2. 102810. FDA. Danger: Don't Drink Miracle Mineral Solution or Similar Products. Available at: https://www.fda.gov/consumers/consumer-updates/danger-dont-drink-miracle-mineral-solution-or-similar-products?utm_campaign=FDA%20warns%20consumers%20about%20the%20dangero

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • Nausea Additional detail

    Chlorine Dioxide

    Recorded for Chlorine Dioxide in the same Natural Medicines adverse-effect record shown under A fast or pounding heartbeat above.

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

Reported for Chlorine Dioxide but not commonly for Desflurane: confusion, an electrolyte imbalance, bloating or gas and dehydration.

Effects for Desflurane come from the ADVERSE REACTIONS section of its FDA label; effects for Chlorine Dioxide come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Chlorine Dioxide in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally for medicinal purposes. Chlorine dioxide supplement products typically contain 28% sodium chlorite, which can provide 3-8 mg of chlorine dioxide per drop when mixed with citric acid as directed. Chlorine dioxide has been reported to cause serious complications, including severe vomiting and diarrhea, life-threatening low blood pressure, hemolysis, and acute liver failure. There is insufficient reliable information available about the safety of chlorine dioxide when used topically; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Desflurane

This page covers Chlorine Dioxide only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Desflurane page lists 22 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Fever Bark (major), Cannabis (moderate), Coffee Charcoal (moderate) and Cowhage (moderate).

By severity: 2 major · 11 moderate · 9 minor.

From our pharmacist’s overview on the Desflurane page

“The interaction to understand first is fever bark with desflurane, the inhaled anesthetic that keeps patients asleep during surgery. Fever bark contains reserpine, tied to unstable heart function and blood pressure under general anesthesia, and it carries one of two major ratings among the 22 supplements on file.”

Reviewed by 2 · Jul 18, 2026

Open the Desflurane interaction page

How much people look this up

Where Chlorine Dioxide and Desflurane Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chlorine Dioxide
Steady interest

#1,377 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Desflurane
Top half

#1,381 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chlorine Dioxide reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chlorine Dioxide and Desflurane records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chlorine Dioxide

What is Chlorine Dioxide?

Chlorine Dioxide
  • Falsely promoted as a cure for infections
  • Falsely promoted for COVID-19
  • Falsely promoted for cancer
  • Falsely promoted for autism
  • Water disinfection (industrial/regulated use only)

Chlorine dioxide products sold as 'Miracle Mineral Solution' (MMS) and similar names are essentially industrial bleach and are not safe to swallow. The FDA has issued strong warnings that drinking these products can cause serious, life-threatening harm, and there is no legitimate evidence they treat any disease. Do not consume chlorine dioxide supplements under any circumstances.

Not a plant; a chemical compound (chlorine dioxide gas, ClO2) · Liquid drops sold as 'Miracle Mineral Solution' (MMS), sodium chlorite solution mixed with an acid 'activator', water purification solution

An interaction check asks whether these two react with each other — it does not ask whether Chlorine Dioxide is a good idea for someone in your situation. Here is what our Chlorine Dioxide record says about it on its own.

Chlorine Dioxide: dosing

There is no safe or recommended dose of chlorine dioxide to take as a supplement. Health authorities, including the FDA, advise that these products should not be consumed at all.Any 'protocol' or dosing instructions found online or on product labels for MMS-type products should be ignored. If you have any of these products, do not use them. If you have already taken some, contact a healthcare provider or poison control right away.

From our Chlorine Dioxide monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chlorine Dioxide monograph & all interactions
Medication

About Desflurane

What Is Desflurane Used For?

Brand name: Suprane

Desflurane (available as Desflurane USP and Suprane) is a general anesthetic given by inhalation during surgery. In adults, it is approved both to start (induce) anesthesia and to keep it going (maintain) throughout inpatient and outpatient procedures.

In infants and children, desflurane is approved only for maintaining anesthesia — and only after anesthesia has first been started with a different agent and the child has been intubated (a breathing tube placed). It is not approved to start anesthesia in children, and it must not be used to maintain anesthesia in children who are not intubated.

See full Desflurane drug information
Keep checking

Other Drugs & Chlorine Dioxide

Browse every other medication we’ve checked against Chlorine Dioxide — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Chlorine Dioxide against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Chlorine Dioxide list.

See the full Chlorine Dioxide interactions page
See every supplement checked against Desflurane, ranked by severity
Evidence & sources

Chlorine Dioxide References

The 10 references that drive our Chlorine Dioxide monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Olin AC, Granung G, Hagberg S, et al. Respiratory health among bleachery workers exposed to ozone and chlorine dioxide. Scand J Work Environ Health. 2002 Apr;28(2):117-23. PubMed
  2. Kishan H. Chlorine dioxide-induced acute hemolysis. J Med Toxicol. 2009 Sep;5(3):177.
  3. Loh JM, Shafi H. Kikuchi-Fujimoto disease presenting after consumption of 'Miracle Mineral Solution' (sodium chlorite). BMJ Case Rep. 2014 Nov 24;2014:bcr2014205832. PubMed
  4. Moore GS, Calabrese EJ, Ho SC. Groups at potentially high risk from chlorine dioxide treated water. J Environ Pathol Toxicol. 1980 Sep;4(2-3):465-70.
  5. FDA. Danger: Don't Drink Miracle Mineral Solution or Similar Products. Available at: https://www.fda.gov/consumers/consumer-updates/danger-dont-drink-miracle-mineral-solution-or-similar-products?utm_campaign=FDA%20warns%20consumers%20about%20the%20dangero
  6. Agency for Toxic Substances and Disease Registry (ATSDR). ToxFAQs for Chlorine Dioxide and Chlorite. September 2004. Available at: https://www.atsdr.cdc.gov/toxfaqs/tfacts160.pdf. Accessed on May 4, 2020.
  7. Burke D, Zakhary B, Pinelis E. Acute Hemolysis Following an Overdose of Miracle Mineral Solution in a Patient With Normal Glucose-6-Phosphate Dehydrogenase Levels. Chest. 2014;146(4_MeetingAbstracts):273A. DOI
  8. Medina-Avitia E, Tella-Vega P, García-Estrada C. Acute kidney injury secondary to chlorine dioxide use for COVID-19 prevention. Hemodial Int. 2021 Oct;25(4):E40-E43. PubMed
  9. Lardieri A, Cheng C, Jones SC, McCulley L. Harmful effects of chlorine dioxide exposure. Clin Toxicol (Phila). 2021 May;59(5):448-9. PubMed
  10. Arellano-Gutiérrez G, Aldana-Zaragoza EH, Pérez-Fabián A. Intestinal perforation associated with chlorine dioxide ingestion: an adult chronic consumer during COVID-19 pandemic. Clin J Gastroenterol. 2021 Dec;14(6):1655-60. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chlorine Dioxide and Desflurane Together: Common Questions

Is it safe to take Chlorine Dioxide with Desflurane?
We do not list a known interaction between Chlorine Dioxide and Desflurane. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Chlorine Dioxide and Desflurane have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Desflurane interact with any supplements?
Yes. Desflurane has documented interactions with 22 supplements in our database — Chlorine Dioxide is not one of them. The Desflurane interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chlorine Dioxide monograph Uses, safety profile, and every drug interaction in one place Desflurane drug information The full plain-English guide to this medication Desflurane supplement interactions Every supplement checked against Desflurane, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Desflurane and Chlorine Dioxide?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.