Chlorine Dioxide + Tofacitinib
Tofacitinib brand names: Xeljanz, Xeljanz XR.
We found no known interaction between Chlorine Dioxide and Tofacitinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Chlorine Dioxide and Tofacitinib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Tofacitinib and Chlorine Dioxide in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Chlorine Dioxide at all — not against Tofacitinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Chlorine Dioxide safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Chlorine Dioxide in Pregnancy & Breastfeeding
When used orally for medicinal purposes. Chlorine dioxide supplement products typically contain 28% sodium chlorite, which can provide 3-8 mg of chlorine dioxide per drop when mixed with citric acid as directed. Chlorine dioxide has been reported to cause serious complications, including severe vomiting and diarrhea, life-threatening low blood pressure, hemolysis, and acute liver failure. There is insufficient reliable information available about the safety of chlorine dioxide when used topically; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Tofacitinib
This page covers Chlorine Dioxide only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tofacitinib page lists 184 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).
By severity: 3 major · 143 moderate · 38 minor.
From our pharmacist’s overview on the Tofacitinib page
“Supplements deserve genuine care alongside tofacitinib (Xeljanz, Xeljanz XR), a medicine that deliberately dials down the immune system to control conditions like rheumatoid arthritis and ulcerative colitis. Most of the interactions on this page run through the liver enzymes that clear the drug, meaning an herb can push its blood level…”
Reviewed by 2 · Jul 18, 2026
Where Chlorine Dioxide and Tofacitinib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,367 of 1,452 supplements looked up here in the last 7 days
#1,223 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chlorine Dioxide reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chlorine Dioxide and Tofacitinib records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Chlorine Dioxide
What is Chlorine Dioxide?
- Falsely promoted as a cure for infections
- Falsely promoted for COVID-19
- Falsely promoted for cancer
- Falsely promoted for autism
- Water disinfection (industrial/regulated use only)
Chlorine dioxide products sold as 'Miracle Mineral Solution' (MMS) and similar names are essentially industrial bleach and are not safe to swallow. The FDA has issued strong warnings that drinking these products can cause serious, life-threatening harm, and there is no legitimate evidence they treat any disease. Do not consume chlorine dioxide supplements under any circumstances.
Not a plant; a chemical compound (chlorine dioxide gas, ClO2) · Liquid drops sold as 'Miracle Mineral Solution' (MMS), sodium chlorite solution mixed with an acid 'activator', water purification solution
An interaction check asks whether these two react with each other — it does not ask whether Chlorine Dioxide is a good idea for someone in your situation. Here is what our Chlorine Dioxide record says about it on its own.
Chlorine Dioxide: dosing
There is no safe or recommended dose of chlorine dioxide to take as a supplement. Health authorities, including the FDA, advise that these products should not be consumed at all.Any 'protocol' or dosing instructions found online or on product labels for MMS-type products should be ignored. If you have any of these products, do not use them. If you have already taken some, contact a healthcare provider or poison control right away.
From our Chlorine Dioxide monograph — the full record covers uses, side effects and every documented interaction.
About Tofacitinib
What Is Tofacitinib Used For?
Brand names: Xeljanz, Xeljanz XR
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Tofacitinib is used alone or with other medications to treat rheumatoid arthritis (condition in which the body attacks its own joints causing pain, swelling, and loss of function) in adults who are unable to take or did not respond to one or more tumor necrosis factor (TNF) inhibitor medication(s). It is also used to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin) in adults who are unable to take or did not respond to or tolerate one or more TNF inhibitor medication(s). Tofacitinib is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) in adults who are unable to take or who did not respond to one or more TNF inhibitor medication(s). It is also used to treat polyarticular juvenile idiopathic arthritis (PJIA; a type of childhood arthritis that affects five or more joints during the first six months of the condition, causing pain, swelling, and loss of function) in children 2 years and older who are unable to take or who did not respond to one or more TNF inhibitor medication(s). Tofacitinib is in a class of medications called Janus kinase (JAK) inhibitors. It works by decreasing the activity of the immune system.
Other Drugs & Chlorine Dioxide
Browse every other medication we’ve checked against Chlorine Dioxide — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Chlorine Dioxide against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Chlorine Dioxide list.
Chlorine Dioxide References
The 10 references that drive our Chlorine Dioxide monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Olin AC, Granung G, Hagberg S, et al. Respiratory health among bleachery workers exposed to ozone and chlorine dioxide. Scand J Work Environ Health. 2002 Apr;28(2):117-23. PubMed
- Kishan H. Chlorine dioxide-induced acute hemolysis. J Med Toxicol. 2009 Sep;5(3):177.
- Loh JM, Shafi H. Kikuchi-Fujimoto disease presenting after consumption of 'Miracle Mineral Solution' (sodium chlorite). BMJ Case Rep. 2014 Nov 24;2014:bcr2014205832. PubMed
- Moore GS, Calabrese EJ, Ho SC. Groups at potentially high risk from chlorine dioxide treated water. J Environ Pathol Toxicol. 1980 Sep;4(2-3):465-70.
- FDA. Danger: Don't Drink Miracle Mineral Solution or Similar Products. Available at: https://www.fda.gov/consumers/consumer-updates/danger-dont-drink-miracle-mineral-solution-or-similar-products?utm_campaign=FDA%20warns%20consumers%20about%20the%20dangero
- Agency for Toxic Substances and Disease Registry (ATSDR). ToxFAQs for Chlorine Dioxide and Chlorite. September 2004. Available at: https://www.atsdr.cdc.gov/toxfaqs/tfacts160.pdf. Accessed on May 4, 2020.
- Burke D, Zakhary B, Pinelis E. Acute Hemolysis Following an Overdose of Miracle Mineral Solution in a Patient With Normal Glucose-6-Phosphate Dehydrogenase Levels. Chest. 2014;146(4_MeetingAbstracts):273A. DOI
- Medina-Avitia E, Tella-Vega P, García-Estrada C. Acute kidney injury secondary to chlorine dioxide use for COVID-19 prevention. Hemodial Int. 2021 Oct;25(4):E40-E43. PubMed
- Lardieri A, Cheng C, Jones SC, McCulley L. Harmful effects of chlorine dioxide exposure. Clin Toxicol (Phila). 2021 May;59(5):448-9. PubMed
- Arellano-Gutiérrez G, Aldana-Zaragoza EH, Pérez-Fabián A. Intestinal perforation associated with chlorine dioxide ingestion: an adult chronic consumer during COVID-19 pandemic. Clin J Gastroenterol. 2021 Dec;14(6):1655-60. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Chlorine Dioxide and Tofacitinib Together: Common Questions
Is it safe to take Chlorine Dioxide with Tofacitinib?
Do Chlorine Dioxide and Tofacitinib have any of the same side effects?
Does Tofacitinib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.