Drug & supplement interaction

Chondroitin Sulfate + Atorvastatin

Atorvastatin brand name: Atorvaliq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Chondroitin Sulfate and Atorvastatin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Chondroitin Sulfate and Atorvastatin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Atorvastatin and Chondroitin Sulfate in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chondroitin Sulfate safety at a glance

Chondroitin Sulfat... overall Use caution Generally well tolerated for short-term use, but quality varies and benefit is uncertain.
Pregnancy Avoid Not enough safety information; avoid during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Atorvastatin and Chondroitin Sulfate? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Atorvastatin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Atorvastatin is filed under 7 classifications — including hmg-coa reductase inhibitors ("statins"), organic anion-transporting polypeptide substrates (oatp), glucuronidated drugs. Chondroitin Sulfate has documented interactions with 1 drug class — the most serious being warfarin (coumadin) (moderate) — and none of Atorvastatin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chondroitin Sulfate Does Interact With Other Medications

Chondroitin Sulfate has 2 moderate known drug interactions in our database — Atorvastatin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 2 No known interaction 2,828 (incl. Atorvastatin)
Taking anything else?

Check Another of Your Medications Against Chondroitin Sulfate

Covers the 2,830 medications we’ve checked against Chondroitin Sulfate. Pick one to open its full report.

What to actually watch for

What Chondroitin Sulfate Itself Has Been Linked To

This is not an interaction — nothing below involves Atorvastatin. It is the side-effect record for Chondroitin Sulfate on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Chondroitin Sulfate, this list is the first place to look. 6 entries are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine / A higher chance of infection Worth acting on Additional detail

    “Intravesical chondroitin sulfate has been associated with cases of vulvar burning, vaginitis, urinary tract infection (UTI), dysuria, pelvic pain, and other bladder symptoms, such as increased frequency, urgency, or incontinence. However, these effects might be due to catheterization rather than chondroitin sulfate.”

    Chondroitin Sulfate · Natural Medicines adverse-effect record, reported in pain.

    3 sources cited
    1. 42385. Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
    2. 42387. Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
    3. 42473. Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
  • A heart attack / Heart failure Worth acting on Additional detail

    “One case of congestive heart failure and another case of myocardial infarction has been possibly attributed to use of glucosamine hydrochloride and chondroitin sulfate. Also, a case of mesenteric occlusion in one patient was considered possibly related to treatment with chondroitin sulfate and glucosamine.”

    Chondroitin Sulfate · Natural Medicines adverse-effect record, reported in congestive heart failure (chf).

    3 sources cited
    1. 13579. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
    2. 42477. Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
    3. 89520. Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
  • Yellowing of the skin or eyes Worth acting on Additional detail

    “Although relatively uncommon, combinations of glucosamine and chondroitin sulfate have been associated with acute liver injury that mimics autoimmune hepatitis. Two cases of elevated aminotransferase levels have been reported for patients taking glucosamine (form unspecified) and chondroitin sulfate at recommended doses.”

    Chondroitin Sulfate · Natural Medicines adverse-effect record, reported in fatigue.

    3 sources cited
    1. 89515. Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
    2. 89518. von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
    3. 89522. Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
  • Wheezing Worth acting on Additional detail

    “A case of asthma exacerbation has been reported occurred following use of an oral glucosamine and chondroitin sulfate combination product.”

    Chondroitin Sulfate · Natural Medicines adverse-effect record, reported in asthma.

    1 source cited
    1. 10002. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  • Hives Worth acting on Additional detail

    “Orally, chondroitin sulfate has been associated with skin symptoms, such as eyelid edema, lower limb edema, alopecia, and skin rash. Combinations of chondroitin sulfate along with glucosamine hydrochloride may also be associated with rash, water retention around eyes and scars, and hives on face, chest, torso, and legs when taken orally.”

    Chondroitin Sulfate · Natural Medicines adverse-effect record, reported in alopecia.

    5 sources cited
    1. 42513. Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
    2. 42436. Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
    3. 110628. Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
    4. 10408. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
    5. 42385. Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
  • Liver problems Worth acting on Additional detail

    “Orally and topically, chondroitin sulfate is generally well tolerated. Intramuscular and ophthalmic use also seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Abdominal pain, bloating, constipation, diarrhea, heartburn, nausea.

    Serious Adverse Effects (Rare):

    Orally: There have been rare reports of hepatotoxicity.”

    Chondroitin Sulfate · Natural Medicines adverse-effect record, reported in constipation.

  • Heartburn Additional detail

    Recorded for Chondroitin Sulfate in the same Natural Medicines adverse-effect record shown under Liver problems above.

  • Sun sensitivity Additional detail

    Recorded for Chondroitin Sulfate in the same Natural Medicines adverse-effect record shown under Hives above.

Showing the 10 most notable of 22 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Chondroitin Sulfate — expand a row for the licensed statement it rests on. We haven’t matched Atorvastatin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Atorvastatin.

Overlapping uses

What Atorvastatin Is Prescribed For, and What Chondroitin Sulfate Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Atorvastatin is a prescription medicine with approved uses on its FDA label. Chondroitin Sulfate is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Atorvastatin is prescribed for: Atorvastatin is used alongside a healthy diet to lower LDL ("bad") cholesterol, triglycerides (blood fats), and other harmful lipids, while raising HDL ("good") cholesterol. It treats primary hyperlipidemia (high cholesterol), mixed dyslipidemia (mixed abnormal blood fats), hypertriglyceridemia (high triglycerides), and inherited conditions such as heterozygous and homozygous familial hypercholesterolemia — including in children aged 10 and older. Beyond cholesterol control, atorvastatin is used to reduce the risk of heart attack, stroke, revascularization procedures, and angina (chest pain) in adults with coronary heart disease or multiple risk factors for it — including adults with type 2 diabetes who have risk factors for heart disease even without a confirmed heart disease diagnosis.

Chondroitin Sulfate has been studied for:

  • Hyperlipidemia studied, not established Chondroitin Sulfate has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Chondroitin Sulfate for hyperlipidemia

    Although there is interest in using oral chondroitin for hyperlipidemia, there is insufficient reliable information about the clinical effects of chondroitin for this condition.

  • Stroke studied, not established Chondroitin Sulfate has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Chondroitin Sulfate for stroke

    It is unclear if oral chondroitin sulfate is beneficial for reducing stroke risk.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Atorvastatin on your own; if you are taking Chondroitin Sulfate for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Chondroitin Sulfate or Atorvastatin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Chondroitin Sulfate or Atorvastatin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Atorvastatin

This page covers Chondroitin Sulfate only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atorvastatin page lists 181 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Green Tea (major).

By severity: 9 major · 136 moderate · 36 minor.

From our pharmacist’s overview on the Atorvastatin page

“Grapefruit is the entry to understand first. Atorvastatin (Atorvaliq) is cleared by an enzyme called CYP3A4, and grapefruit blocks that enzyme, letting statin levels climb along with the risk of side effects like muscle pain.”

Reviewed by 2 · Jul 18, 2026

Open the Atorvastatin interaction page

One more smart check

Taking Chondroitin Sulfate as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,347 real supplement products containing Chondroitin Sulfate, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chondroitin Sulfate. Even though Chondroitin Sulfate itself has no known interaction with Atorvastatin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chondroitin Sulfate and Atorvastatin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chondroitin Sulfate
Top 10%

#108 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Atorvastatin
Top 1%

#27 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chondroitin Sulfate reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Chondroitin Sulfate and Atorvastatin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chondroitin Sulfate

What is Chondroitin Sulfate?

  • Osteoarthritis joint pain
  • Joint stiffness
  • Cartilage support
  • Dry eye (eye drops)

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report modest relief while large studies show little or no benefit—but it appears generally well tolerated. Talk with your pharmacist or doctor before starting, especially if you have allergies or other health conditions.

Cartilage from animal sources (cattle, pig, shark, or fish) · Capsules, tablets, powders (often combined with glucosamine)

An interaction check asks whether these two react with each other — it does not ask whether Chondroitin Sulfate is a good idea for someone in your situation. Here is what our Chondroitin Sulfate record says about it on its own.

Chondroitin Sulfate: dosing

There is no single official dose of chondroitin sulfate that is agreed upon for everyone. It is often taken once daily or split into smaller doses through the day, and it is frequently combined with glucosamine in joint-support products.The best approach is to follow the directions on the product label and not take more than recommended.

From our Chondroitin Sulfate monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chondroitin Sulfate monograph & all interactions
Medication

About Atorvastatin

What Is Atorvastatin Used For?

Brand name: Atorvaliq

Atorvastatin is used alongside a healthy diet to lower LDL ("bad") cholesterol, triglycerides (blood fats), and other harmful lipids, while raising HDL ("good") cholesterol. It treats primary hyperlipidemia (high cholesterol), mixed dyslipidemia (mixed abnormal blood fats), hypertriglyceridemia (high triglycerides), and inherited conditions such as heterozygous and homozygous familial hypercholesterolemia — including in children aged 10 and older.

Beyond cholesterol control, atorvastatin is used to reduce the risk of heart attack, stroke, revascularization procedures, and angina (chest pain) in adults with coronary heart disease or multiple risk factors for it — including adults with type 2 diabetes who have risk factors for heart disease even without a confirmed heart disease diagnosis.

See full Atorvastatin drug information
Keep checking

Other Drugs & Chondroitin Sulfate

Browse every other medication we’ve checked against Chondroitin Sulfate — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
2Moderate
0Minor
2,827No known interaction
2 Moderate 2,827 No interaction
Moderate

2 interactions

No interaction 2,827 drugs checked — show the list

We also checked Chondroitin Sulfate against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Chondroitin Sulfate list.

See the full Chondroitin Sulfate interactions page
See every supplement checked against Atorvastatin, ranked by severity
Evidence & sources

Chondroitin Sulfate References

The 22 references that drive our Chondroitin Sulfate monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  3. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
  4. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
  5. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
  6. Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
  7. Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
  8. Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
  9. Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
  10. Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
  11. Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
  12. Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
  13. Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
  14. Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
  15. Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chondroitin Sulfate and Atorvastatin Together: Common Questions

Is it safe to take Chondroitin Sulfate with Atorvastatin?
We do not list a known interaction between Chondroitin Sulfate and Atorvastatin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Chondroitin Sulfate and Atorvastatin used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Chondroitin Sulfate in each. That is a conversation for your prescriber, especially if Atorvastatin is being adjusted to a target.
How was the Chondroitin Sulfate and Atorvastatin combination checked?
Interactions in our licensed database are recorded against drug classes. Atorvastatin is filed under 7 classifications, and Chondroitin Sulfate has documented interactions with 1 drug class — none of Atorvastatin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Chondroitin Sulfate interact with any other medications?
Yes. Chondroitin Sulfate has 2 documented drug interactions in our database — Atorvastatin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Atorvastatin interact with any supplements?
Yes. Atorvastatin has documented interactions with 181 supplements in our database — Chondroitin Sulfate is not one of them. The Atorvastatin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chondroitin Sulfate monograph Uses, safety profile, and every drug interaction in one place Atorvastatin drug information The full plain-English guide to this medication Atorvastatin supplement interactions Every supplement checked against Atorvastatin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 22 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Atorvastatin and Chondroitin Sulfate?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.