Drug & supplement interaction

Chuchuhuasi + Nivolumab

Nivolumab brand name: Opdivo.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Chuchuhuasi and Nivolumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Nivolumab states a food rule worth keeping to.

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Interaction report

Chuchuhuasi and Nivolumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Nivolumab and Chuchuhuasi in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Chuchuhuasi at all — not against Nivolumab, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chuchuhuasi safety at a glance

Chuchuhuasi overall Use caution It has a long history of traditional use but very little modern safety or quality testing, so use cautiously.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid it to be safe.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Nivolumab and Chuchuhuasi? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Nivolumab’s Own FDA Label Lists

This is not an interaction — none of it involves Chuchuhuasi. These are the most notable effects listed in the ADVERSE REACTIONS section of Nivolumab’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Low magnesium Worth acting on
  • A change in thyroid levels Worth acting on
  • A stroke or mini-stroke Worth acting on
  • Severe muscle breakdown Worth acting on
  • Dehydration Worth acting on
  • Trouble swallowing Worth acting on
  • Bleeding in the gut Worth acting on
  • High potassium Worth acting on
  • Low sodium Worth acting on
  • Low blood sugar Worth acting on

Showing the 10 most notable of 67 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Nivolumab. Read the label on DailyMed › Where a percentage is shown, it is the share of 96,645 voluntary FDA FAERS reports for Nivolumab that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Chuchuhuasi’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Chuchuhuasi side to compare — that is a limit of the record, not a statement that Chuchuhuasi has no side effects.

How to take them

Some Nivolumab Products Have a Food Rule — Chuchuhuasi Should Not Break It

At least one FDA label for a product containing Nivolumab says to take it on an empty stomach. Most supplements — Chuchuhuasi included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Nivolumab on its own and move Chuchuhuasi to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Nivolumab products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Table 2: Recommended Dosages of Intravenous OPDIVO in Combination with Other Therapeutic Agents Indication Recommended OPDIVO Dosage Duration of Therapy Unresectable or metastatic melanoma 1 mg/kg every 3 weeks with ipilimumab 3 mg/kg In combination with ipilimumab for a maximum of 4 doses or until unacceptable toxicity, whichever occurs earlier Adult patients and pediatric patients aged 12 years

From the Dosage and Administration section of the FDA label we read for Nivolumab — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Nivolumab

This page covers Chuchuhuasi only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nivolumab page lists 1 supplement it has a documented interaction with, worst first, each one explained.

The most serious there right now: American Pawpaw (minor).

By severity: 1 minor.

From our pharmacist’s overview on the Nivolumab page

“Nivolumab (Opdivo) is an immunotherapy infusion that trains the body's own immune system to recognize and attack cancer cells, the kind of drug you might expect to carry a long list of supplement warnings. It does not.”

Reviewed by 2 · Jul 18, 2026

Open the Nivolumab interaction page

One more smart check

Taking Chuchuhuasi as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Chuchuhuasi, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chuchuhuasi. Even though Chuchuhuasi itself has no known interaction with Nivolumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chuchuhuasi and Nivolumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chuchuhuasi
Steady interest

#853 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Nivolumab
Top half

#768 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Chuchuhuasi is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chuchuhuasi reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Chuchuhuasi and Nivolumab records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chuchuhuasi

What is Chuchuhuasi?

  • Arthritis and joint pain
  • Back pain and muscle aches
  • Inflammation
  • Menstrual cramps
  • General tonic and energy
  • Digestive complaints

Chuchuhuasi is an Amazonian tree bark traditionally used for joint pain, inflammation, and as a general tonic. Solid human studies are lacking, so its benefits remain unproven, and you should talk to your pharmacist or doctor before trying it—especially if you are pregnant, breastfeeding, or taking other medicines.

Maytenus krukovii · Celastraceae · Bark (mainly the inner bark) and roots · Tinctures, capsules, dried bark for tea/decoction, liquid extracts, and bark soaked in aguardiente (local rum)

An interaction check asks whether these two react with each other — it does not ask whether Chuchuhuasi is a good idea for someone in your situation. Here is what our Chuchuhuasi record says about it on its own.

Chuchuhuasi: dosing

There is no established or standardized dose for chuchuhuasi. Because human studies are lacking, no one has determined a safe and effective amount.If you choose to try it, the safest approach is to follow the directions on the product label and not exceed them. Choose products from reputable companies that test for quality and purity.

From our Chuchuhuasi monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chuchuhuasi monograph & all interactions
Medication

About Nivolumab Injection

What Is Nivolumab Injection Used For?

Brand name: Opdivo

Opdivo (nivolumab) is used to treat many types of cancer in adults, and some in patients 12 years and older. It can be used alone or in combination with other therapies depending on the cancer type and stage. Cancers it treats include melanoma (including after surgery to reduce the chance of the cancer coming back), non-small cell lung cancer, malignant pleural mesothelioma, advanced renal cell carcinoma (kidney cancer), classical Hodgkin lymphoma, squamous cell carcinoma of the head and neck, urothelial carcinoma (bladder cancer), colorectal cancer with specific genetic features (MSI-H or dMMR), hepatocellular carcinoma (liver cancer), esophageal cancer, gastroesophageal junction cancer, and gastric (stomach) cancer.

Some uses require the tumor to test positive for a protein called PD-L1, and some are specific to certain stages of disease or prior treatments received. Your oncologist will determine which use applies to your situation.

Most-Reported Side Effects for Nivolumab

From FAERS, the FDA’s public side-effect reporting system (96,645 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Malignant neoplasm progression 9,878 reports
Diarrhea 5,251 reports
Fatigue 4,195 reports
Fever 3,721 reports
Nausea 3,182 reports
See full Nivolumab Injection drug information
Keep checking

Other Drugs & Chuchuhuasi

Browse every other medication we’ve checked against Chuchuhuasi — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Chuchuhuasi against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Chuchuhuasi list.

See the full Chuchuhuasi interactions page
See every supplement checked against Nivolumab, ranked by severity
Evidence & sources

Chuchuhuasi References

The 3 sources that drive our Chuchuhuasi monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Chuchuhuasi is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health (NCCIH) Source
  2. Herbs and Supplements — MedlinePlus (U.S. National Library of Medicine) Source
  3. About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chuchuhuasi and Nivolumab Together: Common Questions

Is it safe to take Chuchuhuasi with Nivolumab?
We do not list a known interaction between Chuchuhuasi and Nivolumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Chuchuhuasi and Nivolumab at the same time of day?
At least one FDA label for a product containing Nivolumab says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Nivolumab on its own and move Chuchuhuasi to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Nivolumab interact with any supplements?
Yes. Nivolumab has documented interactions with 1 supplement in our database — Chuchuhuasi is not one of them. The Nivolumab interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chuchuhuasi monograph Uses, safety profile, and every drug interaction in one place Nivolumab Injection drug information The full plain-English guide to this medication Nivolumab supplement interactions Every supplement checked against Nivolumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Nivolumab and Chuchuhuasi?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.