Drug & supplement interaction

Clary Sage + tipranavir

tipranavir brand name: Aptivus.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Clary Sage and tipranavir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for tipranavir states a food rule worth keeping to.

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Interaction report

Clary Sage and tipranavir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between tipranavir and Clary Sage in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Clary Sage at all — not against tipranavir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Clary Sage safety at a glance

Clary Sage overall Use caution Generally considered safe as a diluted essential oil for aromatherapy, but it should not be taken by mouth.
Pregnancy Avoid Often discouraged in pregnancy because it is traditionally linked to uterine activity, so avoid it.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining tipranavir and Clary Sage? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What tipranavir’s Own FDA Label Lists

This is not an interaction — none of it involves Clary Sage. These are the most notable effects listed in the ADVERSE REACTIONS section of tipranavir’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • Dehydration Worth acting on
  • Anemia Worth acting on
  • Shortness of breath Worth acting on
  • A low white blood cell count Worth acting on
  • Bleeding or bruising Worth acting on
  • Weight loss
  • Vomiting mentioned in 19.9% of FDA reports for tipranavir
  • Nausea mentioned in 20.5% of FDA reports for tipranavir
  • Numbness or tingling
  • Muscle pain

Showing the 10 most notable of 17 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for tipranavir. Read the label on DailyMed › Where a percentage is shown, it is the share of 1,379 voluntary FDA FAERS reports for tipranavir that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Clary Sage’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Clary Sage side to compare — that is a limit of the record, not a statement that Clary Sage has no side effects.

How to take them

Some tipranavir Products Have a Food Rule — Clary Sage Should Not Break It

At least one FDA label for a product containing tipranavir says to take it with food. If you take Clary Sage on an empty stomach out of habit, keep them separate — and take tipranavir with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two tipranavir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.2 ) APTIVUS taken with ritonavir tablets must be taken with meals ( 2.1 ) APTIVUS capsules must be swallowed whole and must not be opened or chewed ( 2.1 ) Children should be assessed for their ability to swallow capsules before prescribing APTIVUS capsules.

From the Dosage and Administration section of the FDA label we read for tipranavir — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With tipranavir

This page covers Clary Sage only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the tipranavir page lists 212 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 165 moderate · 44 minor.

From our pharmacist’s overview on the tipranavir page

“Keeping tipranavir (Aptivus) at a steady blood level is what keeps HIV suppressed, so this is a supplement list that deserves genuine care, and the three major-rated entries come first. St.”

Reviewed by 2 · Jul 18, 2026

Open the tipranavir interaction page

One more smart check

Taking Clary Sage as Part of a Dietary Supplement Product? Check It for Interactions

We hold 31 real supplement products containing Clary Sage, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Clary Sage. Even though Clary Sage itself has no known interaction with tipranavir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Clary Sage and tipranavir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Clary Sage
Steady interest

#1,288 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication tipranavir
Steady interest

#2,040 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Clary Sage reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Clary Sage and tipranavir records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Clary Sage

What is Clary Sage?

  • Stress and anxiety
  • Menstrual cramps
  • Menopause symptoms
  • Aromatherapy and relaxation
  • Skin care

Clary sage is a Mediterranean herb most often used as an essential oil for aromatherapy and to ease stress or menstrual discomfort. Evidence for these uses is limited and mostly from small studies, and the oil should never be swallowed and should always be diluted before skin contact.

Salvia sclarea · Lamiaceae · Flowering tops and leaves (essential oil) · Essential oil, aromatherapy blends, diluted topical oils

An interaction check asks whether these two react with each other — it does not ask whether Clary Sage is a good idea for someone in your situation. Here is what our Clary Sage record says about it on its own.

Clary Sage: dosing

There is no official or standardized dose for clary sage, and it is not meant to be taken by mouth as a supplement.For aromatherapy, people typically add a few drops to a diffuser or dilute a small amount in a carrier oil before applying it to the skin.

From our Clary Sage monograph — the full record covers uses, side effects and every documented interaction.

Read the full Clary Sage monograph & all interactions
Medication

About Tipranavir

What Is Tipranavir Used For?

Brand name: Aptivus

Aptivus (tipranavir) is used to treat HIV-1 infection in adults and in pediatric patients weighing 36 kg or more who have already tried other HIV medications and whose virus has become resistant to more than one protease inhibitor. It must always be taken together with ritonavir to work properly.

Aptivus is not recommended for people who have never been treated for HIV before. It works best when combined with other active HIV medications, and a resistance test is usually done first to confirm the virus will respond to it.

See full Tipranavir drug information
Keep checking

Other Drugs & Clary Sage

Browse every other medication we’ve checked against Clary Sage — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Clary Sage against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Clary Sage list.

See the full Clary Sage interactions page
See every supplement checked against tipranavir, ranked by severity
Evidence & sources

Clary Sage References

The 2 references that drive our Clary Sage monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ou, M. C., Hsu, T. F., Lai, A. C., Lin, Y. T., and Lin, C. C. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial. J Obstet.Gynaecol.Res 2012;38(5):817-822. PubMed
  2. Amirhosseini M, Dehghan M, Mangolian Shahrbabaki P, Pakmanesh H. Effectiveness of aromatherapy for relief of pain, nausea, and vomiting after percutaneous nephrolithotomy: a randomized controlled trial. Complement Med Res 2020:1-9. Online ahead of print. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Clary Sage and tipranavir Together: Common Questions

Is it safe to take Clary Sage with tipranavir?
We do not list a known interaction between Clary Sage and tipranavir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Clary Sage and tipranavir at the same time of day?
At least one FDA label for a product containing tipranavir says to take it with food. If you take Clary Sage on an empty stomach out of habit, keep them separate and take tipranavir with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two tipranavir products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does tipranavir interact with any supplements?
Yes. tipranavir has documented interactions with 212 supplements in our database — Clary Sage is not one of them. The tipranavir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Clary Sage monograph Uses, safety profile, and every drug interaction in one place Tipranavir drug information The full plain-English guide to this medication tipranavir supplement interactions Every supplement checked against tipranavir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About tipranavir and Clary Sage?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.