St. John's Wort + tipranavir
tipranavir brand name: Aptivus.
tipranavir falls into 6 drug categories that St. John's Wort can interact with; the most serious is rated major. St. John's wort increases the metabolism and reduces the levels of CYP3A4 substrates.
Read the full interaction reportSt. John's Wort and tipranavir
These two interact in 6 distinct ways. Each one is explained separately below.
Why Are There 6 Interactions?
St. John's Wort interacts with whole categories of medication. tipranavir falls into 6 of those categories, so it can interact with St. John's Wort in 6 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Major).
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
1 of 6Why this applies to tipranavir
tipranavir falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group St. John's Wort interacts with.
St. John's wort induces CYP3A4 enzymes and increases metabolism of CYP3A4 substrates. Clinically significant interactions have been reported with St. John's wort products containing hyperforin 1 mg or more.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
Here's the concern with pairing tipranavir (Aptivus) with St. John's wort. Your body clears tipranavir partly through a liver enzyme called CYP3A4. St. John's wort speeds that enzyme up, so it can push tipranavir out of your system faster. Lower drug levels mean the medicine may not hold your HIV in check the way it should.
This matters a lot. If tipranavir levels drop, the virus can rebound and even build resistance, which makes your HIV harder to treat down the road. This isn't a guess from one weak study alone, it's a well-recognized, serious interaction with HIV protease inhibitors. Please don't add or stop anything on your own. Talk with your HIV doctor or pharmacist first so your treatment stays on track.
- Henderson L, Yue QY, Bergquist C, et al. St John's wort (Hypericum perforatum): drug interactions and clinical outcomes. Br J Clin Pharmacol 2002;54:349-56..
- Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St. John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 2003;290:1500-4.. PubMed
- Gurley BJ, Gardner SF, Hubbard MA, et al. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther 2002;72:276-87.. PubMed
- Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003;10:334-42.. PubMed
- Komoroski BJ, Zhang S, Cai H, et al. Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. Drug Metab Dispos 2004;32:512-8. PubMed
- Smith M, Lin KM, and Zheng YP. PIII-89 an open trial of nifedipine-herb interactions: Nifedipine with St. John's wort, ginseng or ginkgo biloba. Clin Pharm Ther 2001;69:P86.
- Kawaguchi, A., Ohmori, M., Tsuruoka, S., Nishiki, K., Harada, K., Miyamori, I., Yano, R., Nakamura, T., Masada, M., and Fujimura, A. Drug interaction between St John's Wort and quazepam. Br.J.Clin Pharmacol. 2004;58(4):403-410. PubMed
- Dresser, G. K., Schwarz, U. I., Wilkinson, G. R., and Kim, R. B. Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects. Clin Pharmacol Ther 2003;73(1):41-50. PubMed
- Patel, J., Buddha, B., Dey, S., Pal, D., and Mitra, A. K. In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: changes in P-gp and CYP3A4 activity. Am.J.Ther. 2004;11(4):262-277. PubMed
- Izzo, A. A. and Ernst, E. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Drugs 2009;69(13):1777-1798. PubMed
- Chrubasik-Hausmann S, Vlachojannis J, McLachlan AJ. Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content. J Pharm Pharmacol. 2018.
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Pochet S, Lechon AS, Lescrainier C, et al. Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database. Sci Rep 2022;12(1):14178. PubMed
- Gümüs KS, Teegelbekkers A, Sauter M, et al. Effect of Tacrolimus Formulation (Prolonged-Release vs Immediate-Release) on Its Susceptibility to Drug-Drug Interactions with St. John's Wort. Clin Pharmacol Drug Dev 2024. PubMed
P-GLYCOPROTEIN SUBSTRATES
2 of 6tipranavir also falls under P-GLYCOPROTEIN SUBSTRATES.
St. John's wort induces P-glycoprotein. P-glycoprotein is a carrier mechanism responsible for transporting drugs and other substances across cell membranes. When P-glycoprotein is induced in the gastrointestinal (GI) tract, it can prevent the absorption of some medications. In addition, induction of p-glycoprotein can decrease entry of drugs into the central nervous system (CNS) and decrease access to other sites of action.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
Here's the concern with pairing St. John's wort with tipranavir (Aptivus). This herb revs up a transport system called P-glycoprotein, and it also speeds up liver enzymes that handle many HIV medicines. The end result is the same direction: your body clears tipranavir faster and absorbs less of it, so blood levels drop.
With an HIV protease inhibitor, lower levels are a real problem. If the drug falls below the level needed to suppress the virus, HIV can rebound and, worse, develop resistance, meaning this medication (and similar ones) may stop working for you. That's why St. John's wort is generally avoided with these drugs. Please don't start or stop anything on your own. Talk with your pharmacist or HIV doctor first so they can keep your treatment working.
- Johne A, Brockmoller J, Bauer S, et al. Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum). Clin Pharmacol Ther 1999;66:338-45.
- Durr D, Stieger B, Kullak-Ublick GA, et al. St. John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clin Pharmacol Ther 2000;68:598-604. PubMed
- Hennessy M, Kelleher D, Spiers JP, et al. St Johns wort increases expression of P-glycoprotein: implications for drug interactions. Br J Clin Pharmacol 2002;53:75-82.
- Kim RB. Drugs as P-glycoprotein substrates, inhibitors, and inducers. Drug Metab Rev 2002;34:47-54. PubMed
PROTEASE INHIBITORS (PIs)
3 of 6tipranavir also falls under PROTEASE INHIBITORS (PIs).
In healthy volunteers, St. John's wort can reduce the plasma concentrations of indinavir (Crixivan) by inducing cytochrome P450 3A4 (CYP3A4). This might result in treatment failure and viral resistance. St. John's wort also induces P-glycoprotein, which can result in decreased intracellular protease inhibitor concentrations and increased elimination.
Well-controlled human studies have demonstrated the likely existence of this interaction.
Here's the big concern with combining these two. St. John's wort revs up a liver enzyme called CYP3A4 and a transporter called P-glycoprotein, both of which help clear tipranavir (Aptivus) out of your body. When that clearance speeds up, the amount of tipranavir in your blood drops. Tipranavir is an active drug, not a prodrug, so lower levels simply mean weaker HIV control.
Why this matters: less drug can mean the virus is no longer kept in check, and that can lead to treatment failure and drug resistance. That kind of resistance is hard to undo. This is rated a major, likely interaction, so please don't start St. John's wort while on tipranavir. Talk with your HIV provider or pharmacist first about safer options for mood.
- Piscitelli SC, Burstein AH, Chaitt D, et al. Indinavir concentrations and St John's wort. Lancet 2000;355:547-8. PubMed
- Schulz V. Incidence and clinical relevance of the interactions and side effects of Hypericum preparations. Phytomedicine 2001;8:152-60.
- Henderson L, Yue QY, Bergquist C, et al. St John's wort (Hypericum perforatum): drug interactions and clinical outcomes. Br J Clin Pharmacol 2002;54:349-56..
- Soleymani S, Bahramsoltani R, Rahimi R, Abdollahi M. Clinical risks of St John's Wort (Hypericum perforatum) co-administration. Expert Opin Drug Metab Toxicol. 2017;13(10):1047-62.
CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES
4 of 6tipranavir also falls under CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES.
Preliminary clinical research in healthy males shows that taking St. John's wort for 14 days induces CYP2C19 and increases metabolism of mephenytoin (Mesantoin). In patients with wild-type 2C19 (2C19*1/*1) metabolism was almost 4-fold greater in subjects who received St. John's wort compared to placebo. In contrast, patients with 2C19*2/*2 and *2/*3 genotypes did not demonstrate a similar increase in metabolism. Theoretically, St. John's wort might increase metabolism of other CYP2C19 substrates.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the concern with pairing St. John's wort and tipranavir (Aptivus). This herb is a powerful 'inducer,' meaning it can rev up the liver enzymes that break down many medicines. With your HIV regimen, that's a problem, because faster breakdown can drop tipranavir levels in your blood. Tipranavir is the active drug (not a prodrug needing activation), so lower levels mean less virus-fighting power.
The worry isn't a side effect, it's losing control of the virus and even helping HIV become resistant. This combination is generally considered one to avoid. Please don't change anything on your own. Talk with your HIV doctor or pharmacist first so they can keep your treatment working as it should.
- Wang LS, Zhu B, Abd El-Aty A, et al. The influence of St. John's wort on CYP2C19 activity with respect to genotype. J Clin Pharmacol 2004;44:577-81. PubMed
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
5 of 6tipranavir also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.
Clinical and in vitro research shows that St. John's wort induces CYP1A2, but to a lesser extent than CYP3A4.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the concern with pairing St. John's wort and tipranavir (Aptivus). St. John's wort acts as an inducer, meaning it tells your body to clear certain drugs faster. Tipranavir is an active HIV medicine (not a prodrug that needs switching on), so speeding up its breakdown can drop its blood levels. Lower levels can let HIV multiply again and may even encourage the virus to become resistant, which puts your treatment at real risk.
While the file notes St. John's wort's effect on this particular enzyme (CYP1A2) is modest, tipranavir is one drug where you don't want to gamble with falling levels. Please don't start or stop anything on your own. Talk with your HIV doctor or pharmacist first, since this combination is generally one to avoid.
- Henderson L, Yue QY, Bergquist C, et al. St John's wort (Hypericum perforatum): drug interactions and clinical outcomes. Br J Clin Pharmacol 2002;54:349-56..
- Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003;10:334-42.. PubMed
- Van Strater, A. C. and Bogers, J. P. Interaction of St John's wort (Hypericum perforatum) with clozapine. Int.Clin.Psychopharmacol. 2012;27(2):121-124. PubMed
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES
6 of 6tipranavir also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.
There is contradictory research about the effect of St. John's wort on CYP2C9. Some in vitro research shows that St. John's wort induces CYP2C9, but to a lesser extent than CYP3A4. St. John's wort also induces metabolism of the S-warfarin isomer, which is a CYP2C9 substrate. Other research shows that St. John's wort 300 mg three times daily for 21 days does not significantly affect the pharmacokinetics of a single 400 mg dose of ibuprofen, which is also a CYP2C9 substrate. Until more is known, use St. John's wort cautiously in patients who are taking CYP2C9 substrates.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist: St. John's wort can speed up the enzymes your body uses to clear medicines like tipranavir (Aptivus). When that happens, the level of tipranavir in your blood can drop. Since this drug is working to keep HIV in check, lower levels are a real concern. The worry isn't more side effects, it's the opposite problem: the medicine may not work as well, which can let the virus rebound and even build resistance over time.
Tipranavir is an active drug (not a prodrug), so faster breakdown simply means less of it doing its job. The evidence here is mixed and rated moderate, but with an HIV medication I don't take chances. Please don't start or stop anything on your own. Loop in your doctor or pharmacist first so they can keep your treatment on track.
- Henderson L, Yue QY, Bergquist C, et al. St John's wort (Hypericum perforatum): drug interactions and clinical outcomes. Br J Clin Pharmacol 2002;54:349-56..
- Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003;10:334-42.. PubMed
- Komoroski BJ, Zhang S, Cai H, et al. Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. Drug Metab Dispos 2004;32:512-8. PubMed
- Jiang X, Williams KM, Liauw WS, et al. Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 2004;57:592-9. PubMed
- Bell EC, Ravis WR, Lloyd KB, Stokes TJ. Effects of St. John's wort supplementation on ibuprofen pharmacokinetics. Ann Pharmacother 2007;41:229-34. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
St. John's Wort Also Interacts With Other Medications
St. John's Wort has 754 major, 388 moderate known drug interactions in our database — the tipranavir one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against St. John's Wort
We haven’t checked that one against St. John's Wort yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against St. John's Wort. Pick one to open its full report.
Questions About St. John's Wort or tipranavir
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers St. John's Wort or tipranavir, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Is St. John's Wort Safe To Take With Diovan (Valsartan)? ›
- How Can You Switch From Zoloft To St. John's Wort? ›
- Is Tylenol Safe To Take With St. John's Wort? ›
- Can You Take St. John's Wort With Prozac? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With tipranavir
This page covers St. John's Wort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the tipranavir page lists 212 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), 1,3-dmaa (moderate), Acacia Rigidula (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).
By severity: 3 major · 165 moderate · 44 minor.
From our pharmacist’s overview on the tipranavir page
“Keeping tipranavir (Aptivus) at a steady blood level is what keeps HIV suppressed, so this is a supplement list that deserves genuine care, and the three major-rated entries come first. St.”
Reviewed by 2 · Jul 18, 2026
Taking St. John's Wort as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1,159 real supplement products containing St. John's Wort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides St. John's Wort. Your product may carry other ingredients that interact with tipranavir too, on top of St. John's Wort — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where St. John's Wort and tipranavir Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#158 of 1,452 supplements looked up here in the last 7 days
#1,541 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About St. John's Wort
What is St. John's Wort?
- Mild to moderate depression
- Anxiety and stress
- Sleep problems
- Menopausal symptoms
- Wound healing (topical)
St. John's wort is a well-studied herb most often used for mild to moderate depression, and some research suggests it may help with this. However, it has many serious interactions with prescription medicines and is not safe for everyone, so always talk to your pharmacist or doctor before taking it.
About Tipranavir
What Is Tipranavir Used For?
Brand name: Aptivus
Aptivus (tipranavir) is used to treat HIV-1 infection in adults and in pediatric patients weighing at least 36 kg (about 79 lbs). It is specifically for people who have already tried other HIV treatments and whose virus has become resistant to more than one protease inhibitor. It is always taken together with a low dose of ritonavir and with other HIV medications.
Aptivus is not recommended for people who have never taken HIV treatment before (treatment-naïve patients). Using tipranavir alongside additional active HIV drugs improves the chances of it working well.
Other Drugs & St. John's Wort
Browse every other medication we’ve checked against St. John's Wort — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
754 interactions
- Diltiazem ›
- Nifedipine ›
- Hydrocortisone ›
- Pancrelipase (prescription Drug) ›
- Doxycycline ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Tetracycline ›
- Lidocaine ›
- Ranitidine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Doxorubicin ›
- Fluticasone ›
- Miconazole ›
- Morphine Sulfate ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Ivermectin ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Rifampin ›
- Testosterone Undecanoate ›
- Aripiprazole ›
- Betamethasone ›
- Caffeine (otc Drug) ›
- Ciclesonide ›
- Cimetidine ›
- Clonazepam ›
- Cyclobenzaprine ›
- Dapsone ›
- Digoxin ›
- Doxycycline Hyclate ›
- Erythromycin Ethylsuccinate ›
Showing 60 of 754 major interactions — see all 754 on the St. John's Wort page.
388 interactions
- Diclofenac Sodium ›
- Theophylline ›
- Ibuprofen ›
- Diphenhydramine ›
- Methylphenidate ›
- Naproxen ›
- Propranolol ›
- Hydrochlorothiazide ›
- Glyburide ›
- Bupropion ›
- Ciprofloxacin ›
- Flurbiprofen ›
- Isotretinoin ›
- Orphenadrine ›
- Diclofenac Potassium ›
- Formoterol ›
- Indomethacin ›
- Phenylephrine ›
- Procainamide ›
- Tazarotene ›
- Trimipramine ›
- Acetaminophen ›
- Etodolac ›
- Griseofulvin ›
- Ketoprofen ›
- Lofepramine ›
- Meloxicam ›
- Nortriptyline ›
- Ofloxacin ›
- Selegiline ›
- Sumatriptan Succinate ›
- Topiramate ›
- Tretinoin ›
- Trichlormethiazide ›
- Azithromycin ›
- Bendamustine ›
- Bendroflumethiazide ›
- Desipramine ›
- Doxepin ›
- Duloxetine ›
- Fluphenazine ›
- Interferon Alfa-2b ›
- Interferon Beta-1b ›
- Levofloxacin ›
- Lisinopril ›
- Metoclopramide ›
- Metolazone ›
- Paroxetine ›
- Riluzole ›
- Sulfasalazine ›
- Valproic Acid ›
- Vortioxetine ›
- Acetazolamide ›
- Aminolevulinic Acid Hydrochloride ›
- Asenapine ›
- Brompheniramine ›
- Captopril ›
- Carisoprodol ›
- Carvedilol ›
- Celecoxib ›
Showing 60 of 388 moderate interactions — see all 388 on the St. John's Wort page.
No interaction 1,687 drugs checked — show the list
We also checked St. John's Wort against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Metoprolol ›
- Aspirin ›
- Valacyclovir ›
- Docusate ›
- Hydroxyurea ›
- Semaglutide ›
- Tirzepatide ›
- Acyclovir ›
- Metformin ›
- Amoxicillin ›
- Lamotrigine ›
- Methotrexate ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Mannitol ›
- Cephalexin ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Daptomycin ›
- Hexobarbitone ›
- Levothyroxine Sodium ›
- Levetiracetam ›
- Mitomycin ›
- Minoxidil ›
- Cefaclor ›
- Factor 7a ›
- Carbidopa, Levodopa ›
- Thyroid Hormone ›
- Ezetimibe ›
- Levodopa ›
- Vancomycin ›
- Spironolactone ›
- Dirithromycin ›
- Lenvatinib ›
- Hethylphenidate Hcl ›
- Azelaic Acid ›
- Bentoquatam ›
- Tenecteplase ›
- Amoxicillin, Clavulanate Potassium ›
- Hydroxychloroquine ›
- Codeine Sulfate ›
- Dextrothyroxine ›
- Triptorelin ›
- Lomustine ›
- Acetylsalicylic Acid ›
- Succimer ›
- Pentobarbitone ›
- Flecainide ›
- Tocainide ›
- Codeine Phosphate ›
- Rocuronium ›
- Halothane ›
- Lorazepam ›
Showing the 60 most looked-up of 1,687 medications checked with no known interaction — see the full St. John's Wort list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking St. John's Wort and tipranavir Together: Common Questions
Can you take St. John's Wort with tipranavir?
Why are there 6 interactions listed for St. John's Wort and tipranavir?
How serious is the St. John's Wort and tipranavir interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About tipranavir and St. John's Wort?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.