Drug & supplement interaction

Clay + Sirolimus

Sirolimus brand name: Rapamune.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Clay and Sirolimus in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Clay and Sirolimus

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sirolimus and Clay in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Clay safety at a glance

Clay overall Use caution Topical use is generally low-risk, but oral clay can be contaminated with heavy metals.
Pregnancy Possibly Unsafe When used orally, long-term. Clay ingestion during pregnancy appears to be associated with an increased incidence of pre-eclampsia, hypertension, and/or edema.... Read the full pregnancy detail
Breastfeeding Avoid Not enough safety data; avoid taking clay by mouth while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sirolimus and Clay? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sirolimus

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sirolimus is filed under 5 classifications — including immunosuppressants, p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates. Clay has documented interactions with 2 drug classes — the most serious being cimetidine (tagamet) (moderate) and quinine (moderate) — and none of Sirolimus’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Clay Does Interact With Other Medications

Clay has 3 moderate known drug interactions in our database — Sirolimus isn’t one of them. If you take anything else, check it against the full list below.

Moderate 3 No known interaction 2,827 (incl. Sirolimus)
Taking anything else?

Check Another of Your Medications Against Clay

Covers the 2,830 medications we’ve checked against Clay. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Clay and Sirolimus May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Low potassium Worth acting on Additional detail

    Clay

    “Orally, clay seems to be well tolerated when used short-term. Adverse effects are generally mild and include constipation, vomiting, and diarrhea. Long-term ingestion of clay has been associated with more serious adverse effects.”

    Clay · Natural Medicines adverse-effect record, reported in anemia.

    6 sources cited
    1. 26617. Wang JS, Luo H, Billam M, et al. Short-term safety evaluation of processed calcium montmorillonite clay (NovaSil) in humans. Food Addit Contam 2005;22(3):270-9. PubMed
    2. 98648. Kee BK, Morris JS, Slack RS, et al. A phase II, randomized, double blind trial of calcium aluminosilicate clay versus placebo for the prevention of diarrhea in patients with metastatic colorectal cancer treated with irinotecan. Support Care Cancer. 2015;2 PubMed
    3. 98652. Lin JX, Fan ZY, Lin Q, et al. A comparison of dioctahedral smectite and iodine glycerin cream with topical mouth rinse in treatment of chemotherapy induced oral mucositis: a pilot study. Eur J Oncol Nurs. 2015;19(2):136-41. PubMed
    4. 98646. Pérez-Gaxiola G, Cuello-García CA, Florez ID, Pérez-Pico VM. Smectite for acute infectious diarrhoea in children. Cochrane Database Syst Rev. 2018;4:CD011526. PubMed
    5. 98649. Mitchell NJ, Kumi J, Aleser M, et al. Short-term safety and efficacy of calcium montmorillonite clay (UPSN) in children. Am J Trop Med Hyg. 2014;91(4):777-85. PubMed
    6. 101813. Lai BY, Liang N, Cao HJ, et al. Pediatric Tui Na for acute diarrhea in children under 5 years old: A systematic review and meta-analysis of randomized clinical trials. Complement Ther Med. 2018;41:10-22. PubMed

    “Clay possesses potassium-binding capacity, and chronic clay ingestion has been associated with severe hypokalemia. A case report describes a 60-year-old female who habitually ingested clay (geophagia) and presented with severe hypokalemia, moderate hypophosphatemia, flaccid paralysis, muscle weakness, and rhabdomyolysis with a very high creatine kinase level.”

    Clay · Natural Medicines adverse-effect record, reported in hypokalemia.

    5 sources cited
    1. 26604. Gonzalez JJ, Owens W, Ungaro PC, et al. Clay ingestion: a rare cause of hypokalemia. Ann Intern Med 1982;97(1):65-6. PubMed
    2. 26605. Mengel CE, Carter WA, Horton ES. Geophagia with iron deficiency and hypokalemia. Cachexia Africana. Arch Intern Med 1964;114:470-4. PubMed
    3. 26606. Severance HW Jr, Holt T, Patrone NA, Chapman L. Profound muscle weakness and hypokalemia due to clay ingestion. South Med J 1988;81(2):272-4. PubMed
    4. 26623. Bennett A, Stryjewski G. Severe hypokalemia caused by oral and rectal administration of bentonite in a pediatric patient. Pediatr Emerg Care 2006;22(7):500-2. PubMed
    5. 107378. Schmidt C, Oxley Oxland J, Freercks R. A rare case of hypokalaemia and hypophosphataemia secondary to geophagia. BMJ Case Rep. 2021 May 12;14(5):e239322. PubMed

    Sirolimus

    Listed in the ADVERSE REACTIONS section of the FDA label for Sirolimus. Read the label on DailyMed ›

  • Anemia Worth acting on Additional detail

    Clay

    “Orally, habitual clay intake may lead to iron malabsorption and severe iron deficiency, and has been associated with anemia.”

    Clay · Natural Medicines adverse-effect record, reported in anemia.

    5 sources cited
    1. 26605. Mengel CE, Carter WA, Horton ES. Geophagia with iron deficiency and hypokalemia. Cachexia Africana. Arch Intern Med 1964;114:470-4. PubMed
    2. 26607. Minnich V, Okcuoglu A, Tarcon Y, et al. Pica in Turkey. II. Effect of clay upon iron absorption. Am J Clin Nutr 1968;21(1):78-86.
    3. 26611. Carpenter WM. Observations on Cachexia Africana, on habits and effects of dirt eating in negro race. New Orleans Med Surg J 1844;1:146-68.
    4. 26614. Blum M, Orton C, Rose L. The effect of starch ingestion on excessive iron association, abstracted. Ann Intern Med 1968;68:1165.
    5. 26622. Prasad AS, Halsted JA, Nadimi M. Syndrome of iron deficiency anemia, hepatospelenomegaly, hypogonadism, dwarfism and geophagia. Am J Med 1961;31:532-46.

    Sirolimus

    Listed in the ADVERSE REACTIONS section of the FDA label for Sirolimus. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Clay

    “Orally, habitual clay intake has been associated with heart lesions, cardiomyopathy, and painful heart palpitations.”

    Clay · Natural Medicines adverse-effect record, reported in cardiomyopathy.

    1 source cited
    1. 26611. Carpenter WM. Observations on Cachexia Africana, on habits and effects of dirt eating in negro race. New Orleans Med Surg J 1844;1:146-68.

    Sirolimus

    Listed in the ADVERSE REACTIONS section of the FDA label for Sirolimus. Read the label on DailyMed ›

  • Constipation / Diarrhea Additional detail

    Clay

    “Orally, the most commonly reported adverse effects in clinical trials is constipation. Vomiting and diarrhea have been reported rarely. Long-term ingestion of clay may induce constipation, diarrhea, heartburn, flatulence, loss of appetite, and vomiting after meals. Clay ingestion has also been associated with intestinal obstruction and necrotizing enteritis, leading to bowel perforation.”

    Clay · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 98646. Pérez-Gaxiola G, Cuello-García CA, Florez ID, Pérez-Pico VM. Smectite for acute infectious diarrhoea in children. Cochrane Database Syst Rev. 2018;4:CD011526. PubMed
    2. 101813. Lai BY, Liang N, Cao HJ, et al. Pediatric Tui Na for acute diarrhea in children under 5 years old: A systematic review and meta-analysis of randomized clinical trials. Complement Ther Med. 2018;41:10-22. PubMed
    3. 98649. Mitchell NJ, Kumi J, Aleser M, et al. Short-term safety and efficacy of calcium montmorillonite clay (UPSN) in children. Am J Trop Med Hyg. 2014;91(4):777-85. PubMed
    4. 26611. Carpenter WM. Observations on Cachexia Africana, on habits and effects of dirt eating in negro race. New Orleans Med Surg J 1844;1:146-68.
    5. 26616. Andrews PL, Horn CC. Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases. Auton Neurosci 2006;125(1-2):100-15. PubMed
    6. 26617. Wang JS, Luo H, Billam M, et al. Short-term safety evaluation of processed calcium montmorillonite clay (NovaSil) in humans. Food Addit Contam 2005;22(3):270-9. PubMed

    Sirolimus

    Listed in the ADVERSE REACTIONS section of the FDA label for Sirolimus. Read the label on DailyMed ›

  • Swelling Additional detail

    Clay

    “Cases of hypokalemia-induced muscle weakness and muscle swelling have been reported after ingestion of large quantities of clay.”

    Clay · Natural Medicines adverse-effect record, reported in hypokalemia.

    3 sources cited
    1. 26606. Severance HW Jr, Holt T, Patrone NA, Chapman L. Profound muscle weakness and hypokalemia due to clay ingestion. South Med J 1988;81(2):272-4. PubMed
    2. 26615. Ukaonu C, Hill DA, Christensen F. Hypokalemic myopathy in pregnancy caused by clay ingestion. Obstet Gynecol 2003;102(5 Pt 2):1169-71. DOI
    3. 26627. Trivedi TH, Daga GL, Yeolekar ME. Geophagia leading to hypokalemic quadriparesis in a postpartum patient. J Assoc Physicians India 2005;53:205-7.

    Sirolimus

    Listed in the ADVERSE REACTIONS section of the FDA label for Sirolimus. Read the label on DailyMed ›

Reported for Clay but not commonly for Sirolimus: a bowel blockage, reduced appetite, muscle weakness and severe muscle breakdown.

Effects for Sirolimus come from the ADVERSE REACTIONS section of its FDA label; effects for Clay come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Clay in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally, long-term. Clay ingestion during pregnancy appears to be associated with an increased incidence of pre-eclampsia, hypertension, and/or edema. There is insufficient reliable information available about the safety of ingesting clay short-term during pregnancy.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Clay or Sirolimus

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Clay or Sirolimus, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sirolimus

This page covers Clay only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sirolimus page lists 188 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).

By severity: 3 major · 149 moderate · 36 minor.

From our pharmacist’s overview on the Sirolimus page

“Sirolimus (Rapamune) is the anti-rejection medicine transplant patients depend on, and it is a narrow-therapeutic-index drug, meaning small shifts in its blood level can invite rejection on one side or toxicity on the other. That is why the 188 supplements on this page deserve genuine wariness, starting with the three rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Sirolimus interaction page

One more smart check

Taking Clay as Part of a Dietary Supplement Product? Check It for Interactions

We hold 17 real supplement products containing Clay, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Clay. Even though Clay itself has no known interaction with Sirolimus, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Clay and Sirolimus Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Clay
Steady interest

#899 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sirolimus
Steady interest

#2,157 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Clay reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Clay and Sirolimus records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Clay

What is Clay?

  • Detox and digestive complaints
  • Skin care (masks, acne, irritation)
  • Diarrhea and upset stomach
  • Drawing out toxins or impurities
  • Wound and rash poultices

Clay is a fine, mineral-rich earth (such as bentonite or kaolin) used on the skin and sometimes taken by mouth for digestive and 'detox' purposes. Topical use for masks and minor skin issues is popular and generally low-risk, but swallowing clay carries real safety concerns, including possible contamination with lead and other heavy metals. Talk to a pharmacist or doctor before taking clay internally.

Mineral-rich clay (bentonite, kaolin, French green clay, and similar) · Powder, capsules, masks, poultices, suspensions/drinks

An interaction check asks whether these two react with each other — it does not ask whether Clay is a good idea for someone in your situation. Here is what our Clay record says about it on its own.

Clay: dosing

There is no well-established, standardized dose for clay, and no recommended safe amount for eating it. Because of contamination and absorption concerns, taking clay internally is generally not recommended without medical guidance.If you use a topical product, follow the label directions for how long to leave a mask on and how often to use it. Choose products that are independently tested for heavy metals.

From our Clay monograph — the full record covers uses, side effects and every documented interaction.

Read the full Clay monograph & all interactions
Medication

About Sirolimus

What Is Sirolimus Used For?

Brand name: Rapamune

Sirolimus oral solution and tablets are used to help prevent organ rejection in kidney (renal) transplant patients aged 13 and older. They are also used to treat lymphangioleiomyomatosis (LAM) — a rare lung disease in which abnormal muscle-like cells invade lung tissue.

Fyarro (sirolimus, intravenous injection) is used to treat adults with locally advanced, unresectable, or metastatic malignant PEComa — a rare tumor that grows in soft tissue or organs. Hyftor (sirolimus topical gel) is used to treat facial angiofibroma (small benign skin growths on the face) associated with tuberous sclerosis in adults and children aged 6 and older.

Most-Reported Side Effects for Sirolimus

From FAERS, the FDA’s public side-effect reporting system (13,394 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 525 reports
Diarrhea 515 reports
Pneumonia 487 reports
Acute kidney injury 435 reports
Thrombotic microangiopathy 376 reports
See full Sirolimus drug information
Keep checking

Other Drugs & Clay

Browse every other medication we’ve checked against Clay — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
3Moderate
0Minor
2,826No known interaction
3 Moderate 2,826 No interaction
Moderate

3 interactions

No interaction 2,826 drugs checked — show the list

We also checked Clay against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,826 medications checked with no known interaction — see the full Clay list.

See the full Clay interactions page
See every supplement checked against Sirolimus, ranked by severity
Evidence & sources

Clay References

The 31 references that drive our Clay monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gonzalez JJ, Owens W, Ungaro PC, et al. Clay ingestion: a rare cause of hypokalemia. Ann Intern Med 1982;97(1):65-6. PubMed
  2. Mengel CE, Carter WA, Horton ES. Geophagia with iron deficiency and hypokalemia. Cachexia Africana. Arch Intern Med 1964;114:470-4. PubMed
  3. Severance HW Jr, Holt T, Patrone NA, Chapman L. Profound muscle weakness and hypokalemia due to clay ingestion. South Med J 1988;81(2):272-4. PubMed
  4. Minnich V, Okcuoglu A, Tarcon Y, et al. Pica in Turkey. II. Effect of clay upon iron absorption. Am J Clin Nutr 1968;21(1):78-86.
  5. O'Rourke DE, Quinn JG, Nicholson JO, Gibson HH. Geophagia during pregnancy. Obstet Gynecol 1967;29(4):581-4.
  6. Edwards CE, McDonald S, Mitchell JK, et al. Effect of clay and cornstarch intake on women and their infants. J Amer Diet Assoc 1964;44:109-15. DOI
  7. Carpenter WM. Observations on Cachexia Africana, on habits and effects of dirt eating in negro race. New Orleans Med Surg J 1844;1:146-68.
  8. Ducrotte P, Dapoigny M, Bonaz B, Siproudhis L. Symptomatic efficacy of beidellitic montmorillonite in irritable bowel syndrome: a randomized, controlled trial. Aliment Pharmacol Ther 2005;21(4):435-44. PubMed
  9. Chang FY, Lu CL, Chen CY, Luo JC. Efficacy of dioctahedral smectite in treating patients of diarrhea-predominant irritable bowel syndrome. J Gastroenterol Hepatol 2007;22(12):2266-72. PubMed
  10. Blum M, Orton C, Rose L. The effect of starch ingestion on excessive iron association, abstracted. Ann Intern Med 1968;68:1165.
  11. Ukaonu C, Hill DA, Christensen F. Hypokalemic myopathy in pregnancy caused by clay ingestion. Obstet Gynecol 2003;102(5 Pt 2):1169-71. DOI
  12. Andrews PL, Horn CC. Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases. Auton Neurosci 2006;125(1-2):100-15. PubMed
  13. Wang JS, Luo H, Billam M, et al. Short-term safety evaluation of processed calcium montmorillonite clay (NovaSil) in humans. Food Addit Contam 2005;22(3):270-9. PubMed
  14. Bateson EM, Lebroy T. Clay eating by Aboriginals of the Northern Territory. Med J Aust 1978;1 Suppl 1:1-3. PubMed
  15. Delaitre B, Lemaigre G, Acar JF, et al. [Necrotizing enteritis and geophagia]. Nouv Presse Med 1976;5(28):1743-6.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Clay and Sirolimus Together: Common Questions

Is it safe to take Clay with Sirolimus?
We do not list a known interaction between Clay and Sirolimus. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Clay and Sirolimus have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Clay and Sirolimus combination checked?
Interactions in our licensed database are recorded against drug classes. Sirolimus is filed under 5 classifications, and Clay has documented interactions with 2 drug classes — none of Sirolimus's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Clay interact with any other medications?
Yes. Clay has 3 documented drug interactions in our database — Sirolimus is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sirolimus interact with any supplements?
Yes. Sirolimus has documented interactions with 188 supplements in our database — Clay is not one of them. The Sirolimus interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Clay monograph Uses, safety profile, and every drug interaction in one place Sirolimus drug information The full plain-English guide to this medication Sirolimus supplement interactions Every supplement checked against Sirolimus, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 31 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sirolimus and Clay?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.