Drug & supplement interaction

Colonic Irrigation + Lixisenatide

Lixisenatide brand name: Adlyxin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Colonic Irrigation and Lixisenatide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Colonic Irrigation and Lixisenatide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lixisenatide and Colonic Irrigation in our sources. This does not guarantee that the combination is completely free of risk — research on Colonic Irrigation alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Colonic Irrigation at all — not against Lixisenatide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Colonic Irrigation is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Colonic Irrigation safety at a glance

Colonic Irrigation overall Use caution Generally not recommended; carries risks like cramping, dehydration, and rarely bowel injury.
Pregnancy Avoid Avoid during pregnancy because of risks of dehydration, electrolyte changes, and bowel stimulation.
Breastfeeding Use caution Limited safety information; dehydration and electrolyte loss could affect you—best to avoid or check with your doctor.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lixisenatide and Colonic Irrigation? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Colonic Irrigation Itself Has Been Linked To

This is not an interaction — nothing below involves Lixisenatide. It is the side-effect record for Colonic Irrigation on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Colonic Irrigation, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • An electrolyte imbalance / Low sodium Worth acting on Additional detail

    “The safety and associated side effects of colonic irrigation depend on the method and substances used. While rare, colonic irrigation with tap water has been associated with electrolyte imbalances, namely hyponatremia. The most common side effects are gastrointestinal.”

    Colonic Irrigation · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 96868. Acosta RD, Cash BD. Clinical effects of colonic cleansing for general health promotion: a systematic review. Am J Gastroenterol. 2009;104(11):2830-6. PubMed
    2. 96872. Koch SM, Melenhorst J, van Gemert WG, Baeten CG. Prospective study of colonic irrigation for the treatment of defaecation disorders. Br J Surg. 2008;95(10):1273-9. PubMed
    3. 103272. van Weelden M, Edelenbos E, de Meij T. Persistent hiccups because of water intoxication by colonic irrigation with tap water. ACG Case Rep J. 2019;6(8):e00148.2. PubMed
    4. 96871. Pacilli M, Pallot D, Andrews A, et al. Use of Peristeen® transanal colonic irrigation for bowel management in children: a single-center experience. J Pediatr Surg. 2014;49(2):269-72. PubMed
    5. 96873. Passananti V, Wilton A, Preziosi G, Storrie JB, Emmanuel A. Long-term efficacy and safety of transanal irrigation in multiple sclerosis. Neurogastroenterol Motil. 2016;28(9):1349-55. PubMed
    6. 3026. Margolin KA, Green MR. Polymicrobial enteric septicemia from coffee enemas. West J Med 1984;140:460.

    “Rectally administered coffee enemas used for detoxification have been linked to at least three deaths. One of these deaths was associated with polymicrobial septicemia following use of coffee enema. Two of these deaths were related to severe electrolyte imbalance.

    One case of severe hyponatremia after colonic irrigation with tap water has been reported in a 12-year-old female.”

    Colonic Irrigation · Natural Medicines adverse-effect record, reported in hyponatremia.

    6 sources cited
    1. 3026. Margolin KA, Green MR. Polymicrobial enteric septicemia from coffee enemas. West J Med 1984;140:460.
    2. 3347. Green S. A critique of the rationale for cancer treatment with coffee enemas and diet. JAMA 1992;268:3224-7. DOI
    3. 3349. Shils ME, Herman MG. Unproved dietary claims in the treatment of patients with cancer. Bull N Y Acad Med 1982;58:323-39.
    4. 6652. Brown BT. Treating cancer with coffee enemas and diet. JAMA 1993;269:1635-6. DOI
    5. 103272. van Weelden M, Edelenbos E, de Meij T. Persistent hiccups because of water intoxication by colonic irrigation with tap water. ACG Case Rep J. 2019;6(8):e00148.2. PubMed
    6. 96868. Acosta RD, Cash BD. Clinical effects of colonic cleansing for general health promotion: a systematic review. Am J Gastroenterol. 2009;104(11):2830-6. PubMed
  • Memory problems / Confusion Worth acting on Additional detail

    “There is a case report of a 42-year-old woman female with transient confusion and memory loss due to acute water intoxication-mediated hyponatremia associated with colonic irrigation. In another case, a 12-year-old femalegirl reported persistent hiccups provoked by severe hyponatremia after colonic irrigation with tap water.”

    Colonic Irrigation · Natural Medicines adverse-effect record, reported in memory.

    2 sources cited
    1. 96868. Acosta RD, Cash BD. Clinical effects of colonic cleansing for general health promotion: a systematic review. Am J Gastroenterol. 2009;104(11):2830-6. PubMed
    2. 103272. van Weelden M, Edelenbos E, de Meij T. Persistent hiccups because of water intoxication by colonic irrigation with tap water. ACG Case Rep J. 2019;6(8):e00148.2. PubMed
  • Bleeding or bruising Worth acting on Additional detail

    “Pain on insertion of the catheter has been described. Rarely, leakage after irrigation, abdominal cramps, anal bleeding, and bloating have also occurred. Rectal perforation requiring surgery has occurred very rarely.

    At least 36 cases of amebiasis, with bloody diarrhea, occurred following colonic irrigation at a clinic in Western Colorado between 1978 and 1980. Ten patients required colectomy and 6 died.”

    Colonic Irrigation · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 96871. Pacilli M, Pallot D, Andrews A, et al. Use of Peristeen® transanal colonic irrigation for bowel management in children: a single-center experience. J Pediatr Surg. 2014;49(2):269-72. PubMed
    2. 96872. Koch SM, Melenhorst J, van Gemert WG, Baeten CG. Prospective study of colonic irrigation for the treatment of defaecation disorders. Br J Surg. 2008;95(10):1273-9. PubMed
    3. 96873. Passananti V, Wilton A, Preziosi G, Storrie JB, Emmanuel A. Long-term efficacy and safety of transanal irrigation in multiple sclerosis. Neurogastroenterol Motil. 2016;28(9):1349-55. PubMed
    4. 96868. Acosta RD, Cash BD. Clinical effects of colonic cleansing for general health promotion: a systematic review. Am J Gastroenterol. 2009;104(11):2830-6. PubMed
    5. 103273. Lee AH, Kabashneh S, Tsouvalas CP, et al. Proctocolitis from coffee enema. ACG Case Rep J. 2020;7(1):e00292. PubMed
    6. 108619. Mehershahi S, Ghazanfar H, Ashraf S, Shaikh DH, Patel H. Colitis Induced by Colon-Cleansing Agent. Case Rep Gastroenterol 2021;15(2):621-625. PubMed
  • Bloating or gas / Stomach pain / Diarrhea Additional detail

    Recorded for Colonic Irrigation in the same Natural Medicines adverse-effect record shown under An electrolyte imbalance / Low sodium above.

  • Constipation Additional detail

    Recorded for Colonic Irrigation in the same Natural Medicines adverse-effect record shown under Bleeding or bruising above.

Everything above comes from the Natural Medicines adverse-effect record for Colonic Irrigation — expand a row for the licensed statement it rests on. We haven’t matched Lixisenatide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Lixisenatide.

Everything else you take

See Every Supplement That Interacts With Lixisenatide

This page covers Colonic Irrigation only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lixisenatide page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Lixisenatide page

“Lixisenatide (Adlyxin) is injected to lower blood sugar in type 2 diabetes, and nearly everything on this page acts on blood sugar too, which is why I would treat the list with genuine care rather than a shrug. Most of the entries, from bitter melon and fenugreek to both types of ginseng, can push glucose lower still and raise the odds…”

Reviewed by 2 · Jul 18, 2026

Open the Lixisenatide interaction page

How much people look this up

Where Colonic Irrigation and Lixisenatide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Colonic Irrigation
Steady interest

#1,256 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lixisenatide
Steady interest

#2,093 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Colonic Irrigation reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Colonic Irrigation and Lixisenatide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Treatment approach

About Colonic Irrigation

What is Colonic Irrigation?

  • Colon "cleansing" or "detox"
  • Constipation relief
  • Bloating and digestive discomfort
  • Bowel prep before procedures (enemas)
  • General wellness or "flushing toxins"

Colonic irrigation (colon hydrotherapy) flushes the large intestine with water, often marketed for "detox" and digestive health, but there is little good evidence it provides real health benefits. It can cause uncomfortable and occasionally serious side effects, so it is not recommended for routine use—talk to your doctor or pharmacist before trying it.

Not applicable — this is a procedure, not a plant or supplement · In-clinic colon hydrotherapy session; at-home enema kits

An interaction check asks whether these two react with each other — it does not ask whether Colonic Irrigation is a good idea for someone in your situation. Here is what our Colonic Irrigation record says about it on its own.

Colonic Irrigation: dosing

There is no established safe or recommended "dose" or schedule for colonic irrigation, and it is not a supplement you take by mouth. Sessions vary widely in how much water is used and how long they last.Because of the lack of proven benefit and the potential for harm, most pharmacists and doctors do not recommend routine colonics. If you are considering one, talk with a healthcare professional first, and only use a properly licensed practitioner with sterile, single-use equipment.For medically necessary bowel preparation (such as before a colonoscopy), follow the specific instructions and products your doctor prescribes—this is different from a wellness colonic.

From our Colonic Irrigation monograph — the full record covers uses, side effects and every documented interaction.

Read the full Colonic Irrigation monograph & all interactions
Medication

About Lixisenatide Injection

What Is Lixisenatide Injection Used For?

Brand name: Adlyxin

  • Lixisenatide injection is used along with diet and exercise to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Lixisenatide injection is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). Lixisenatide is not used instead of insulin to treat people with diabetes who need insulin. Lixisenatide injection is in a class of medications called incretin mimetics. It works by stimulating the pancreas to secrete insulin when blood sugar levels are high. Insulin helps move sugar from the blood into other body tissues where it is used for energy. Lixisenatide injection also slows the emptying of the stomach and causes a decrease in appetite.

  • Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with lixisenatide injection and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

See full Lixisenatide Injection drug information
Keep checking

Other Drugs & Colonic Irrigation

Browse every other medication we’ve checked against Colonic Irrigation — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Colonic Irrigation against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Colonic Irrigation list.

See the full Colonic Irrigation interactions page
See every supplement checked against Lixisenatide, ranked by severity
Evidence & sources

Colonic Irrigation References

The 17 references that drive our Colonic Irrigation monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Margolin KA, Green MR. Polymicrobial enteric septicemia from coffee enemas. West J Med 1984;140:460.
  2. Green S. A critique of the rationale for cancer treatment with coffee enemas and diet. JAMA 1992;268:3224-7. DOI
  3. Shils ME, Herman MG. Unproved dietary claims in the treatment of patients with cancer. Bull N Y Acad Med 1982;58:323-39.
  4. Brown BT. Treating cancer with coffee enemas and diet. JAMA 1993;269:1635-6. DOI
  5. Church JM. Warm water irrigation for dealing with spasm during colonoscopy: simple, inexpensive, and effective. Gastrointest Endosc 2002;56(5):672-4. PubMed
  6. Sha LJ, Zhang ZX, Cheng LX. Colonic dialysis therapy of Chinese herbal medicine in abstinance of heroin addicts--report of 75 cases. Zhongguo Zhong Xi Yi Jie He Za Zhi 1997;17(2):76-8.
  7. Briel JW, Schouten WR, Vlot EA, et al. Clinical value of colonic irrigation in patients with continence disturbances. Dis Colon Rectum 1997;40(7):802-5. PubMed
  8. Acosta RD, Cash BD. Clinical effects of colonic cleansing for general health promotion: a systematic review. Am J Gastroenterol. 2009;104(11):2830-6. PubMed
  9. Hsu HH, Leung WH, Hu GC. Treatment of irritable bowel syndrome with a novel colonic irrigation system: a pilot study. Tech Coloproctol. 2016;20(8):551-7. PubMed
  10. Christensen P, Bazzocchi G, Coggrave M, et al. A randomized, controlled trial of transanal irrigation versus conservative bowel management in spinal cord-injured patients. Gastroenterology. 2006;131(3):738-47. PubMed
  11. Pacilli M, Pallot D, Andrews A, et al. Use of Peristeen® transanal colonic irrigation for bowel management in children: a single-center experience. J Pediatr Surg. 2014;49(2):269-72. PubMed
  12. Koch SM, Melenhorst J, van Gemert WG, Baeten CG. Prospective study of colonic irrigation for the treatment of defaecation disorders. Br J Surg. 2008;95(10):1273-9. PubMed
  13. Passananti V, Wilton A, Preziosi G, Storrie JB, Emmanuel A. Long-term efficacy and safety of transanal irrigation in multiple sclerosis. Neurogastroenterol Motil. 2016;28(9):1349-55. PubMed
  14. van Weelden M, Edelenbos E, de Meij T. Persistent hiccups because of water intoxication by colonic irrigation with tap water. ACG Case Rep J. 2019;6(8):e00148.2. PubMed
  15. Lee AH, Kabashneh S, Tsouvalas CP, et al. Proctocolitis from coffee enema. ACG Case Rep J. 2020;7(1):e00292. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Having Colonic Irrigation While Taking Lixisenatide: Common Questions

Is it safe to have Colonic Irrigation while taking Lixisenatide?
We do not list a known interaction between Colonic Irrigation and Lixisenatide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Lixisenatide interact with any supplements?
Yes. Lixisenatide has documented interactions with 239 supplements in our database — Colonic Irrigation is not one of them. The Lixisenatide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Colonic Irrigation monograph Uses, safety profile, and every drug interaction in one place Lixisenatide Injection drug information The full plain-English guide to this medication Lixisenatide supplement interactions Every supplement checked against Lixisenatide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 17 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lixisenatide and Colonic Irrigation?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.