Drug & supplement interaction

Copaiba Balsam + Tasimelteon

Tasimelteon brand names: Hetlioz, Hetlioz Lq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Copaiba Balsam and Tasimelteon in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tasimelteon states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Copaiba Balsam and Tasimelteon

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tasimelteon and Copaiba Balsam in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Copaiba Balsam at all — not against Tasimelteon, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Copaiba Balsam safety at a glance

Copaiba Balsam overall Use caution Generally tolerated in small amounts but human safety data are limited, especially for concentrated oral oil.
Pregnancy Possibly Unsafe When used orally in medicinal amounts; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally in medicinal amounts; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tasimelteon and Copaiba Balsam? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Copaiba Balsam and Tasimelteon May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Trouble sleeping reported in 19.8% of FDA reports for Tasimelteon Additional detail

    Copaiba Balsam

    “Orally, copaiba balsam in repeated doses of 5 grams or more has been reported to cause shivering, tremor, and insomnia (18).”

    Copaiba Balsam · Natural Medicines adverse-effect record, reported in insomnia.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Tasimelteon

    Listed in the ADVERSE REACTIONS section of the FDA label for Tasimelteon, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Copaiba Balsam but not commonly for Tasimelteon: stomach pain, a skin rash, hives and bleeding or bruising.

Effects for Tasimelteon come from the ADVERSE REACTIONS section of its FDA label; effects for Copaiba Balsam come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 5,765 voluntary FDA FAERS reports for Tasimelteon that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Copaiba Balsam in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally in medicinal amounts; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Tasimelteon Products Have a Food Rule — Copaiba Balsam Should Not Break It

At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach. Most supplements — Copaiba Balsam included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Tasimelteon on its own and move Copaiba Balsam to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tasimelteon products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Indicated Population Dosage Form Body Weight Recommended Dosage Non-24 ( 2.2 ) Adults Capsules Not applicable 20 mg one hour prior to bedtime Nighttime sleep disturbances in SMS ( 2.3 ) Patients 16 years of age and older Capsules Not applicable 20 mg one hour prior to bedtime Pediatric Patients 3 to 15 years of age Oral Suspension ≤ 28 kg 0.7 mg/kg one hour before bedti

From the Dosage and Administration section of the FDA label we read for Tasimelteon — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tasimelteon

This page covers Copaiba Balsam only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tasimelteon page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 166 moderate · 43 minor.

From our pharmacist’s overview on the Tasimelteon page

“Tasimelteon (Hetlioz) resets the body clock in people with non-24-hour sleep-wake disorder, and the sleep aids they often reach for, melatonin and kava among them, sit on an interaction list that deserves real respect. Nine of the 218 ingredients on file rate major, mostly in two directions: sedatives like kava stack drowsiness onto a…”

Reviewed by 2 · Jul 18, 2026

Open the Tasimelteon interaction page

One more smart check

Taking Copaiba Balsam as Part of a Dietary Supplement Product? Check It for Interactions

We hold 9 real supplement products containing Copaiba Balsam, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Copaiba Balsam. Even though Copaiba Balsam itself has no known interaction with Tasimelteon, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Copaiba Balsam and Tasimelteon Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Copaiba Balsam
Steady interest

#1,349 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tasimelteon
Steady interest

#2,198 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Copaiba Balsam reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Copaiba Balsam and Tasimelteon records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Copaiba Balsam

What is Copaiba Balsam?

  • Inflammation and joint pain
  • Skin wounds and irritation
  • Antimicrobial and antifungal support
  • Sore throat and respiratory comfort
  • Digestive complaints

Copaiba balsam is a resin from South American Copaifera trees, valued in traditional medicine and now popular as an essential oil and supplement, mainly for inflammation and skin concerns. Human evidence is limited, so its benefits are not well proven. Talk to a pharmacist or doctor before using it, and avoid undiluted oral use of the essential oil.

Copaifera officinalis · Fabaceae · Oleoresin (balsam) tapped from the trunk; essential oil distilled from the resin · Essential oil, oral softgels/capsules, topical creams and ointments, tinctures

An interaction check asks whether these two react with each other — it does not ask whether Copaiba Balsam is a good idea for someone in your situation. Here is what our Copaiba Balsam record says about it on its own.

Copaiba Balsam: dosing

There is no well-established, standardized dose for copaiba balsam. The amount in products varies widely depending on whether it is a topical cream, an oral softgel, or a pure essential oil.The safest approach is to follow the directions on the product label and not exceed them. For topical use, dilute the essential oil in a carrier oil and patch test first. Avoid taking concentrated essential oil by mouth unless a knowledgeable healthcare professional directs you to.

From our Copaiba Balsam monograph — the full record covers uses, side effects and every documented interaction.

Read the full Copaiba Balsam monograph & all interactions
Medication

About Tasimelteon

What Is Tasimelteon Used For?

Brand names: Hetlioz, Hetlioz Lq

Tasimelteon capsules are approved to treat Non-24-Hour Sleep-Wake Disorder (Non-24) in adults. Non-24 is a condition where the body's internal clock does not align with the normal 24-hour day, causing sleep and wake times to shift continuously.

Hetlioz capsules are also approved to treat nighttime sleep disturbances in Smith-Magenis Syndrome (SMS) in patients 16 years of age and older. Hetlioz LQ oral suspension is approved specifically for nighttime sleep disturbances in SMS in pediatric patients ages 3 to 15 years.

Most-Reported Side Effects for Tasimelteon

From FAERS, the FDA’s public side-effect reporting system (5,770 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Insomnia 728 reports
Middle insomnia 414 reports
Somnolence 408 reports
Headache 386 reports
Nightmare 268 reports
See full Tasimelteon drug information
Keep checking

Other Drugs & Copaiba Balsam

Browse every other medication we’ve checked against Copaiba Balsam — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Copaiba Balsam against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Copaiba Balsam list.

See the full Copaiba Balsam interactions page
See every supplement checked against Tasimelteon, ranked by severity
Evidence & sources

Copaiba Balsam References

The 2 references that drive our Copaiba Balsam monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Copaiba Balsam and Tasimelteon Together: Common Questions

Is it safe to take Copaiba Balsam with Tasimelteon?
We do not list a known interaction between Copaiba Balsam and Tasimelteon. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Copaiba Balsam and Tasimelteon have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Copaiba Balsam and Tasimelteon at the same time of day?
At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Tasimelteon on its own and move Copaiba Balsam to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Tasimelteon interact with any supplements?
Yes. Tasimelteon has documented interactions with 218 supplements in our database — Copaiba Balsam is not one of them. The Tasimelteon interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Copaiba Balsam monograph Uses, safety profile, and every drug interaction in one place Tasimelteon drug information The full plain-English guide to this medication Tasimelteon supplement interactions Every supplement checked against Tasimelteon, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tasimelteon and Copaiba Balsam?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.