Drug & supplement interaction

Cudweed + Misoprostol

Misoprostol brand name: Cytotec.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cudweed and Misoprostol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Misoprostol states a food rule worth keeping to.

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Interaction report

Cudweed and Misoprostol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Misoprostol and Cudweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cudweed safety at a glance

Cudweed overall Not established Limited modern safety data exist, so use with caution and talk to a healthcare provider first.
Pregnancy Avoid Not enough safety information is available, so avoid use during pregnancy.
Breastfeeding Avoid There is no reliable safety data, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Misoprostol and Cudweed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Misoprostol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Misoprostol is filed under a single classification — oral drugs. Cudweed has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Misoprostol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cudweed Does Interact With Other Medications

Cudweed has 86 moderate known drug interactions in our database — Misoprostol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Misoprostol)
Taking anything else?

Check Another of Your Medications Against Cudweed

Covers the 2,830 medications we’ve checked against Cudweed. Pick one to open its full report.

What to actually watch for

What Misoprostol’s Own FDA Label Lists

This is not an interaction — none of it involves Cudweed. These are the most notable effects listed in the ADVERSE REACTIONS section of Misoprostol’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Hearing loss Worth acting on
  • Pain or burning when passing urine Worth acting on
  • Dehydration Worth acting on
  • Trouble swallowing Worth acting on
  • Bleeding in the gut Worth acting on
  • A heart attack Worth acting on
  • Blood clots Worth acting on
  • Fainting Worth acting on
  • Wheezing Worth acting on
  • An irregular heartbeat Worth acting on

Showing the 10 most notable of 51 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Misoprostol. Read the label on DailyMed › Where a percentage is shown, it is the share of 16,478 voluntary FDA FAERS reports for Misoprostol that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Cudweed’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Cudweed side to compare — that is a limit of the record, not a statement that Cudweed has no side effects.

How to take them

Some Misoprostol Products Have a Food Rule — Cudweed Should Not Break It

At least one FDA label for a product containing Misoprostol says to take it with food. If you take Cudweed on an empty stomach out of habit, keep them separate — and take Misoprostol with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Misoprostol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION The recommended adult oral dose of Cytotec for reducing the risk of NSAID-induced gastric ulcers is 200 mcg four times daily with food.

From the Dosage and Administration section of the FDA label we read for Misoprostol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Misoprostol

This page covers Cudweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Misoprostol page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Misoprostol page

“Misoprostol (Cytotec) is taken by mouth to protect the stomach lining from ulcers caused by NSAID pain relievers, and all 17 of its recorded supplement interactions come down to the same problem, something in the gut keeping the pill from being absorbed properly. That deserves genuine wariness, because misoprostol that never reaches th…”

Reviewed by 2 · Jul 18, 2026

Open the Misoprostol interaction page

How much people look this up

Where Cudweed and Misoprostol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cudweed
Top half

#659 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Misoprostol
Steady interest

#2,189 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cudweed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cudweed and Misoprostol records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cudweed

What is Cudweed?

  • Mouth and throat irritation
  • Digestive upset
  • Mild high blood pressure (traditional)
  • Minor wounds and skin irritation
  • Coughs and respiratory complaints

Cudweed is a small, woolly-leaved plant used in traditional herbal medicine, mainly as a tea or gargle for sore throats, digestive upset, and minor skin problems. There is very little modern scientific evidence to confirm that it works for any condition, and safety data are limited, so it is best used cautiously and avoided in pregnancy and breastfeeding.

Gnaphalium uliginosum · Asteraceae · Aerial parts (flowering tops, leaves, and stems) · Tea (infusion), tincture, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Cudweed is a good idea for someone in your situation. Here is what our Cudweed record says about it on its own.

Cudweed: dosing

There is no established or standardized dose for cudweed. It has not been studied enough to know a safe and effective amount, and traditional preparations vary.If you choose to use a commercial product, follow the directions on the label and do not exceed the recommended amount.

From our Cudweed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cudweed monograph & all interactions
Medication

About Misoprostol

What Is Misoprostol Used For?

Brand name: Cytotec

Cytotec (misoprostol) tablets and misoprostol tablets are approved to reduce the risk of gastric ulcers (stomach ulcers) in patients who take NSAIDs — nonsteroidal anti-inflammatory drugs such as aspirin, ibuprofen, or diclofenac — and who are at high risk of ulcer complications. High-risk patients include older adults, people with serious ongoing illnesses, and those with a history of stomach ulcers.

It is important to note that misoprostol has not been shown to reduce the risk of duodenal ulcers (ulcers in the first part of the small intestine) in people taking NSAIDs. It also does not relieve the stomach pain or discomfort that NSAIDs can cause.

Most-Reported Side Effects for Misoprostol

From FAERS, the FDA’s public side-effect reporting system (16,478 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hemorrhage 1,322 reports
Abortion incomplete 1,159 reports
Nausea 1,031 reports
Arthralgia 977 reports
Rheumatoid arthritis 805 reports
See full Misoprostol drug information
Keep checking

Other Drugs & Cudweed

Browse every other medication we’ve checked against Cudweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Cudweed page.

No interaction 2,743 drugs checked — show the list

We also checked Cudweed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Cudweed list.

See the full Cudweed interactions page
See every supplement checked against Misoprostol, ranked by severity
Evidence & sources

Cudweed References

The 1 references that drive our Cudweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Shikov AN, Pozharitskaya ON, Makarov VG, et al. Medicinal plants of the Russian Pharmacopoeia; their history and applications. J Ethnopharmacol 2014;154(3):481-536. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cudweed and Misoprostol Together: Common Questions

Is it safe to take Cudweed with Misoprostol?
We do not list a known interaction between Cudweed and Misoprostol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Cudweed and Misoprostol at the same time of day?
At least one FDA label for a product containing Misoprostol says to take it with food. If you take Cudweed on an empty stomach out of habit, keep them separate and take Misoprostol with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Misoprostol products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Cudweed and Misoprostol combination checked?
Interactions in our licensed database are recorded against drug classes. Misoprostol is filed under 1 classification, and Cudweed has documented interactions with 1 drug class — none of Misoprostol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Cudweed interact with any other medications?
Yes. Cudweed has 86 documented drug interactions in our database — Misoprostol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Misoprostol interact with any supplements?
Yes. Misoprostol has documented interactions with 17 supplements in our database — Cudweed is not one of them. The Misoprostol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cudweed monograph Uses, safety profile, and every drug interaction in one place Misoprostol drug information The full plain-English guide to this medication Misoprostol supplement interactions Every supplement checked against Misoprostol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Misoprostol and Cudweed?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.