Drug & supplement interaction

Cursed Buttercup + Abrocitinib

Abrocitinib brand name: Cibinqo.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Cursed Buttercup and Abrocitinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Cursed Buttercup and Abrocitinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Abrocitinib and Cursed Buttercup in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Cursed Buttercup at all — not against Abrocitinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cursed Buttercup safety at a glance

Cursed Buttercup overall Avoid This plant is toxic and can cause skin blistering and serious poisoning if swallowed.
Pregnancy Likely Unsafe When used orally or topically. Oral use of cursed buttercup might stimulate uterine activity. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally or topically. Oral use of cursed buttercup might stimulate uterine activity. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Abrocitinib and Cursed Buttercup? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Cursed Buttercup Itself Has Been Linked To

This is not an interaction — nothing below involves Abrocitinib. It is the side-effect record for Cursed Buttercup on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Cursed Buttercup, this list is the first place to look.

  • Diarrhea Additional detail

    “Orally, fresh cursed buttercup has been reported to cause severe irritation of the gastrointestinal tract, diarrhea, and colic (18).”

    Cursed Buttercup · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Cursed Buttercup — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Abrocitinib’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Abrocitinib column appears here.

Special populations

Cursed Buttercup in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally or topically. Oral use of cursed buttercup might stimulate uterine activity.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Abrocitinib

This page covers Cursed Buttercup only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Abrocitinib page lists 290 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).

By severity: 3 major · 252 moderate · 35 minor.

From our pharmacist’s overview on the Abrocitinib page

“Bleeding is where I'd focus first with abrocitinib (Cibinqo), an eczema pill that can itself lower platelet counts. Of the 290 supplements and herbs with an interaction on file, 202 have blood-thinning or antiplatelet activity, and two of the three major-rated entries, danshen and piracetam, sit in that group.”

Reviewed by 2 · Jul 18, 2026

Open the Abrocitinib interaction page

How much people look this up

Where Cursed Buttercup and Abrocitinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cursed Buttercup
Steady interest

#1,178 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Abrocitinib
Top 5%

#92 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cursed Buttercup reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cursed Buttercup and Abrocitinib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cursed Buttercup

What is Cursed Buttercup?

  • Traditional topical use for skin and joint complaints
  • Folk remedy for warts and skin growths (as a counterirritant)
  • Historical use for fevers
  • Traditional use for swelling or pain

Cursed Buttercup is a toxic wetland plant that can cause severe skin blistering and dangerous poisoning if eaten. It is not a safe or proven dietary supplement, and there is no reliable evidence supporting any medicinal use. Do not take it internally or apply it to your skin without medical supervision—in practice, it is best avoided entirely.

Ranunculus sceleratus · Ranunculaceae · Whole plant (leaves, stems, flowers); historically used topically · Fresh plant poultice or crushed leaves in traditional practice; not sold as a standardized supplement

An interaction check asks whether these two react with each other — it does not ask whether Cursed Buttercup is a good idea for someone in your situation. Here is what our Cursed Buttercup record says about it on its own.

Cursed Buttercup: dosing

There is no established or safe dose of Cursed Buttercup. It is not a recognized dietary supplement, and no reputable product provides standardized, tested amounts.Because the plant is toxic, the safest approach is to not use it at all.

From our Cursed Buttercup monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cursed Buttercup monograph & all interactions
Medication

About Abrocitinib

What Is Abrocitinib Used For?

Brand name: Cibinqo

Cibinqo (abrocitinib) is approved to treat adults and adolescents aged 12 and older who have moderate-to-severe atopic dermatitis (a chronic form of eczema) that has not been adequately controlled with other systemic treatments, including biologic medications, or when those treatments are not appropriate.

It is considered a refractory treatment option — meaning it is used when the disease has been difficult to control with other available therapies. Cibinqo is not recommended to be used alongside other JAK inhibitors, biologic immunomodulators, or other immunosuppressants.

See full Abrocitinib drug information
Keep checking

Other Drugs & Cursed Buttercup

Browse every other medication we’ve checked against Cursed Buttercup — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Cursed Buttercup References

The 2 references that drive our Cursed Buttercup monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cursed Buttercup and Abrocitinib Together: Common Questions

Is it safe to take Cursed Buttercup with Abrocitinib?
We do not list a known interaction between Cursed Buttercup and Abrocitinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Abrocitinib interact with any supplements?
Yes. Abrocitinib has documented interactions with 290 supplements in our database — Cursed Buttercup is not one of them. The Abrocitinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Abrocitinib and Cursed Buttercup?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.